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1Environmental factors influencing snowfall and snowfall prediction in the Tianshan Mountains, Northwest China显示文摘Snowfall is one of the dominant water resources in the mountainous regions and is closely related to the development of the local ecosystem and economy. Snowfall predication plays a critical role in understanding hydrological processes and forecasting natural disasters in the Tianshan Mountains, where meteorological stations are limited. Based on climatic, geographical and topographic variables at 27 meteorological stations during the cold season(October to April) from 1980 to 2015 in the Tianshan Mountains located in Xinjiang of Northwest China, we explored the potential influence of these variables on snowfall and predicted snowfall using two methods: multiple linear regression(MLR) model(a conventional measuring method) and random forest(RF) model(a non-parametric and non-linear machine learning algorithm). We identified the primary influencing factors of snowfall by ranking the importance of eight selected predictor variables based on the relative contribution of each variable in the two models. Model simulations were compared using different performance indices and the results showed that the RF model performed better than the MLR model, with a much higher R^2 value(R^2=0.74; R^2, coefficient of determination) and a lower bias error(RSR=0.51; RSR, the ratio of root mean square error to standard deviation of observed dataset). This indicates that the non-linear trend is more applicable for explaining the relationship between the selected predictor variables and snowfall. Relative humidity, temperature and longitude were identified as three of the most important variables influencing snowfall and snowfall prediction in both models, while elevation, aspect and latitude were of secondary importance, followed by slope and wind speed. These results will be beneficial to understand hydrological modeling and improve management and prediction of water resources in the Tianshan Mountains.ZHANG Xueting LI Xuemei LI Lanhai ZHANG Shan QIN Qirui 2019Journal of Arid Land2019,11,1:8
2Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections.Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang 2020Research2020,,1:7
3Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD.Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang 2022Acta Pharmaceutica Sinica B2022,12,9:3
4Performance and uncertainty analysis of a short-term climate reconstruction based on multi-source data in the Tianshan Mountains region,China显示文摘Short-term climate reconstruction,i.e.,the reproduction of short-term(several decades)historical climatic time series based on the relationship between observed data and available longer-term reference data in a certain area,can extend the length of climatic time series and offset the shortage of observations.This can be used to assess regional climate change over a much longer time scale.Based on monthly grid climate data from a Coupled Model Inter-comparison Project phase 5(CMIP5)dataset for the period of 1850–2000,the Climatic Research Unit(CRU)dataset for the period of 1901–2000 and the observed data from 53 meteorological stations located in the Tianshan Mountains region(TMR)of China during the period of 1961–2011,we calibrated and validated monthly average temperature(MAT)and monthly accumulated precipitation(MAP)in the TMR using the delta,physical scaling(SP)and artificial neural network(ANN)methods.Performance and uncertainty during the calibration(1971–1999)and verification(1961–1970)periods were assessed and compared using traditional performance indices and a revised set pair analysis(RSPA)method.The calibration and verification processes were subjected to various sources of uncertainty due to the influence of different reconstructed variables,different data sources,and/or different methods used.According to traditional performance indices,both the CRU and CMIP5 datasets resulted in satisfactory calibrated and verified MAT time series at 53 meteorological stations and MAP time series at 20 meteorological stations using the delta and SP methods for the period of 1961–1999.However,the results differed from those obtained by the RSPA method.This showed that the CRU dataset produced a low degree of uncertainty(positive connection degree)during the calibration and verification of MAT using the delta and SP methods compared to the CMIP5 dataset.Overall,the calibrated and verified MAP had a high degree of uncertainty(negative connection degree)regardless of the dataset or reconstruction method used.Therefore,the reconstructed time series of MAT for the period of 1850(or 1901)–1960 based on the CRU and CMIP5 datasets using the delta and SP methods could be used for further study.The results of this study will be useful for short-term(several decades)regional climate reconstruction and longer-term(100 a or more)assessments of regional climate change.LI Xuemei Slobodan P SIMONOVIC LI Lanhai ZHANG Xueting QIN Qirui 2020Journal of Arid Land2020,12,3:2
5Pore Characteristics and Factors Controlling Lacustrine Shales from the Upper Cretaceous Qingshankou Formation of the Songliao Basin,Northeast China:A Study Combining SEM,Low-temperature Gas Adsorption and MICP Experiments显示文摘To investigate pore characteristics and the factors controlling lacustrine shales,geochemical,mineralogical and petrophysical experiments were performed on 23 shale samples from the Qingshankou Formation of the Songliao Basin,China.A comparison of mercury injection capillary pressure(MICP)and low-temperature N2 adsorption pore-size distribution showed that MICP has a higher pore-size distribution(PSD)line in its overlapping pore diameter range,which may be elevated by the higher pressure of MICP.Therefore,in the overlapping range,low-temperature N2 adsorption data were preferred in pore characterization.Negative correlations were observed between pore volumes and TOC content,indicating organic matter pores are not well-developed in the studied samples.This may be related to their low grade of maturity and type I kerogens.There existed negative relationships between pore volumes and S1,which illustrated that liquid hydrocarbons occupied some pore space.Micropore volume had a better correlation with S1 than mesopore and macropore volumes,which suggests that liquid hydrocarbons preferentially occur in micropores.No obvious relationships between pore volumes and quartz or feldspar were observed,while pore volumes increased with the increasing clay mineral content.These relationships indicate that intraparticle pores in clay minerals represent the principal pore type.HAN Hui DAI Jie GUO Chen ZHONG Ningning PANG Peng DING Zhengang CHEN Jianping HUANG Zhenkai GAO Yuan LUO Jinyu LI Qirui ZHANG Zhaokun 2021Acta Geologica Sinica(English Edition)2021,95,2:2
6SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron strain(as Rnown as B.1.1.529)was identified in Botswana and South Africa in early November 2021 and was later defined as a new variant of concern(VOC)by the World Health Organization on November 26,2021.1,2 To date,the con firmed cases of Omicro n have been reported in more than 38 countries,and the number of cases appears to be rapidly in creasing.SARS-CoV-2 Omicron could give rise to the fourth wave of the COVID-19 epidemic spreading around the world,following the D614G,Beta/Gamma,and Delta VOCs.Xiantao Zhang Shijian Wu Bolin Wu Qirui Yang Achun Chen Yuzhuang Li Yiwen Zhang Ting Pan Hui Zhang Xin He 2022Signal Transduction and Targeted Therapy2022,7,1:1
72010, Structure and meaning in Chinese: an ERP study of idioms 显示文摘Liu Youyi Ping Li Hua Shu Qirui Zhang & Lang Chen 2010Journal of Neurolinguistics2010,23,:1
8Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cellsinvolving the reversal of differentially expressed long non-coding RNAs显示文摘Qirui Wang Haoning Fan Ying Liu Zhixin Yin Hongbing Cai Jie Liu Zhiyuan Wang Meng Shao Xuegang Sun Jianxin Diao Yuanliang Liu Li Tong Qin Fan 2014International Journal of Oncology2014,,3:1
9Optical property and thermal stability of Mo/Mo - SiO2/SiO2 solar selective coating prepared by magnetron sputtering显示文摘Wang Jian Wei baocheng Wei Qirui Li Dejie 2011Physica Status Solidi A2011,208,:1
10Business processes oriented heterogeneous systems integration platform for networked enterprises 显示文摘LI Qing ZHOU Jian PENG Qirui 2010Special Issue of Computers in Industry2010,61,2:1
11Locating Mechanism of Quartz Vein Gold Deposits in Rushan, Shandong Province显示文摘According to the differences in ore-controlling structural systems and the characteristics of host rocks, textures and structures of ores and mineral associations of ores, quartz vein-type gold deposits in the Rushan area can be divided into the Rushan and Tongling styles. Rushan style gold deposits, occurring in the Kunyushan complex, include Rushan, Tangjiagou and Tongxishan gold mines. They are distributed along four NNE-trending and sinistral, compresso-shear faults with a right stepping array. A prominent characteristic of the gold mineralization is that the orebodies in neighbouring gold deposits distributed in a single ore-controlling fault zone take opposite pitches. Study of the locating structures of the quartz vein gold deposits shows that the Rushan-style gold deposits are characterized by NNE and NE zoning. Therefore, the intersections of the NE direction of the known gold deposit and the neighbouring NNE-trending fault zones are favourable for looking for gold deposits, and the ends ofXIE Hongyuan SHEN Yuanchao WANG Yuejun LI Guangming LIU Tiebing ZHANG Qirui ZEN Qingdong 1998Acta Geologica Sinica(English Edition)1998,72,1:1
12Implications of Stahl's Theorems to Holomorphic Embedding Part II: Numerical Convergence显示文摘What has become known as Stahl's Theorem in power-engineering circles has been used to justify a convergence guarantee of the Holomorphic Embedding Method(HEM)as it applies to the power-flow problem.In this,the second part of a two-part paper,we examine implications to numerical convergence of the HEM and the numerical properties of a Pade approximant algorithm.We show that even if the point of interest is within the convergence domain,numerical convergence of the sequence of Pade approximants computed with finite precision is not guaranteed.We propose a convergence factor equation that can be used to both estimate the convergence rate and the capacity of the branch cut.We also show that the study of convergence properties of the Pade approximant is the study of the location of the branch-points of the function,which in turn dictate branch-cut topology and capacity and,therefore,convergence rate.Abhinav Dronamraju Songyan Li Qirui Li Yuting Li Daniel Tylavsky Di Shi Zhiwei Wang 2021CSEE Journal of Power and Energy Systems2021,7,4:1
13Flux Pinning in Y_(1-x)M_(x)Ba_(2)Cu_(3)O_(7-δ)(M=Gd,Eu and Sm)System显示文摘In this paper,the flux pinning effects in Y_(1-x)M_(x)Ba_(2)Cu_(3)O_(7-δ)(M=Gd,Eu and Sm)samples are reported.It is found that there is another pinning mechanism under higher magnetic fields in addition to that under lower fields.This pinning effect may stem from the lattice stress field resulting from the partial substitution of the rare earth elements with different atomic radii for Y.LI Jonghen FANG Minghu HU Gangjin ZHANG Xiaojun JIAO Zhengkuan ZHANG Qirui ZHANG Yitong JIN Xin YAO Xixian 1992Chinese Physics Letters1992,9,12:0
14g-C_(3)N_(4) Derived Materials for Photocatalytic Hydrogen Production: A Mini Review on Design Strategies显示文摘Hydrogen production through solar energy is one of the most important pathways to meet the growing demand of renewable energy,and photocatalyst participation in solar hydrolytic hydrogen production has received great attention in recent years in terms of low cost,high efficiency,and flexible design.Particularly,g-C_(3)N_(4)(Graphitic-like carbon nitride material),as a unique material,can catalyze the hydrogen production process by completing the separation and transmission of charge.The easily adjustable pore structure/surface area,dimension,band-gap modulation and defect have shown great potential for hydrogen production from water cracking.In this review,the most recent advance of g-C_(3)N_(4) including the doping of metal and non-metal elements,and the formation of semiconductor heterojunction is highlighted.The main modification strategies and approaches for the design of g-C_(3)N_(4) for hydrogen production,as well as the influence of various materials on hydrogen evolution regarding the photocatalysis mechanism and advantages brought by theoretical calculations are specially and briefly illu-strated.Potential design pathways and strategies of g-C_(3)N_(4) are discussed.In addition,current challenges of hydrogen production from g-C_(3)N_(4) water splitting are summarized and can be expected.Kai Su Shaoqi Deng Linxiao Li Qirui Qin Jingyu Yang Yan Chen Shengli Zhang Junming Chen 2022Journal of Renewable Materials2022,10,3:0
15Erratum to:SC79 promotes efficient entry of GDNF liposomes into brain parenchyma to repair dopamine neurons through reversible regulation of tight junction proteins显示文摘Erratum to Nano Research 2023,16(2):2695-2705 http://gffzzd3cc09b8251d45dfs6owwbcc66fp569up.ffgz.tsg.suse.edu.cn/10.1007/s12274-022-4857-6 The article SC79 promotes efficient entry of GDNF liposomes into brain parenchyma to repair dopamine neurons through reversible regulation of tight junction proteins,written by Xiaomei Wu et al.,was erroneously originally published electronically on the publisher’s internet portal(currently SpringerLink)on 14 September 2022 with Fig.1(f)and a zeta potential value in Section 3.1.Xiaomei Wu Li Wang Kai Wang Jia Ke Sufen Li Tingting Meng Hong Yuan Qirui Zhang Fuqiang Hu 2023Nano Research2023,16,7:0
16Epigenetic remodeling by DNA glycosylases during rice reproduction显示文摘Cytosine methylation is a covale nt modificatio n of DNA that regulates important processes in eukaryotic genomes,including gene transcription,transposon silencing,and genomic imprinting(Law and Jacobsen,2010).DNA methylation patterns are faithfully duplicated upon cell division to ensure genome integrity and to maintain lineage-specific cell fate.However,DNA methylation also needs to be dynamically reprogramed or reconfigured during development to allow establishment of new cellular identity and transcriptional state,which plays a prominent role in animal development and reproduction,and is increasingly being appreciated for reproductive success in flowering plants(Walker et al.,2018;Ono and Kinoshita,2021).Mingzhuo Li Qirui Cui Xiang-Qian Zhang Tzung-Fu Hsieh 2021Molecular Plant2021,14,9:0
17Systematic screening and structural characterization of dipeptides using offline 2D LC-LTQ-Orbitrap MS:A case study of Cordyceps sinensis显示文摘Cordyceps sinensis(C.sinensis)is a widely used and highly valuable traditional Chinese medicine.Several dipeptides have been detected in C.sinensis,but current scientific knowledge of its chemical makeup remains limited.In this study,an improved approach that integrates offline two-dimensional liquid chromatography(2D LC)separation,precursor ion list,library screening,and diagnostic ion filtering was established to systematically screen and characterize dipeptides in C.sinensis.Offline 2D LC integrating hydrophilic interaction LC and reverse phase separations was established to eliminate interference and identify the target dipeptides.A library containing the potential 400 dipeptides was created,and a precursor ion list with all theoretical precursor ions was adopted to trigger the MS/MS scan with high sensitivity.To identify dipeptides,the type and connection sequence of amino acids were determined according to the product ions.Ile and Leu residues were differentiated for the first time according to the characteristic ion at m/z 69.07.Ultimately,170 dipeptides were identified or tentatively characterized from C.sinensis,and most are reported for the first time in this species herein.In addition,the identified dipeptides were also applied for discrimination among the three Cordyceps species,and 11 markers were identified.The obtained results provide a deeper understanding of the chemical basis of C.sinensis.Xiaodie Li Changliang Yao Yun Li Zhengming Qian c Wenlong Wei Jianqing Zhang Jiayuan Li Qirui Bi Wenjia Li Yajun Cui De-an Guo 2022Journal of Pharmaceutical Analysis2022,12,2:0
18Influence of cadmium and copper mixtures to rhizosphere bacterial communities显示文摘To study the effects of combined Cd and Cu pollution on rhizosphere bacterial community.High-throughput sequencing was used to examine the response of rhizosphere bacterial communities to heavy-metal stress under single and mixed pollution of cadmium(Cd)and copper(Cu).With additions of Cd and Cu,the mean diversity index of rhizosphere bacterial community was in the order Cu alone>Cd-Cu mixtures>Cd alone.In all Cd and Cu treatments,the dominant phyla were Proteobacteria,Actinobacteria,Chloroflexi and Acidobacteria.In the additions with different concentrations of Cd-Cu mixtures,LEfSe indicated that there were differences in the predominant species of rhizosphere bacterial communities.Some genera such as Streptomyces and Microbacterium belonging to Actinobacteria as biomarkers were significantly enriched in both control and treatments,while some genera such as Pseudoxanthomonas and Rhodopseudomonas belonging to Proteobacteria as biomarkers were observed to be enriched in the additions with single and mixture of Cd and Cu.According to the Nonmetric multidimensional scaling(NMDS)analysis,the structure of rhizosphere bacterial community was different between treatments and the CK.Principal Component Analysis(PCA)and permutational multivariate analysis of variance(PERMANOVA)showed that there were significant differences among treatments(p<0.01),and that the addition of Cu might be the primary factor affecting the composition of rhizosphere bacterial communities.Qirui An Yunyang Li Na Zheng Jincai Ma Shengnan Hou Siyu Sun Sujing Wang Pengyang Li Xiaoqian Li Chunmei Zhao 2023Soil Ecology Letters2023,5,1:0
19Characteristics and health risks of population exposure to phthalates via the use of face towels显示文摘The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations ofWenhui Zhang Na Zheng Sujing Wang Siyu Sun Qirui An Xiaoqian Li Zimeng Li Yining Ji Yunyang Li Jiamin Pan 2023Journal of Environmental Sciences2023,,8:0
20A review of automatic detection of epilepsy based on EEG signals显示文摘Epilepsy is a common neurological disorder that occurs at all ages.Epilepsy not only brings physical pain to patients,but also brings a huge burden to the lives of patients and their families.At present,epilepsy detection is still achieved through the observation of electroencephalography(EEG)by medical staff.However,this process takes a long time and consumes energy,which will create a huge workload to medical staff.Therefore,it is particularly important to realize the automatic detection of epilepsy.This paper introduces,in detail,the overall framework of EEG-based automatic epilepsy identification and the typical methods involved in each step.Aiming at the core modules,that is,signal acquisition analog front end(AFE),feature extraction and classifier selection,method summary and theoretical explanation are carried out.Finally,the future research directions in the field of automatic detection of epilepsy are prospected.Qirui Ren Xiaofan Sun Xiangqu Fu Shuaidi Zhang Yiyang Yuan Hao Wu Xiaoran Li Xinghua Wang Feng Zhang 2023Journal of Semiconductors2023,44,12:0
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