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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Long-Term Effect of Fertilizer and Rice Straw on Mineral Composition and Potassium Adsorption in a Reddish Paddy Soil显示文摘Increasing K+ adsorption can be an effective alternative in building an available K pool in soils to optimize crop recovery and minimize losses into the environment. We hypothesized that long-term fertilization might change K+ adsorption because of changes in the chemical and mineralogical properties of a rice (Oryza sativa L.). The aims of this study were (i) to determine clay minerals in paddy soil clay size fractions using X-ray diffraction methods and a numerical diagram-decomposition method; (ii) to measure K+ adsorption isotherms before and after H 2 O 2 oxidation of organic matter, and (iii) to investigate whether K+ adsorption is correlated with changes in soil chemical and mineral properties. The 30-yr long-term fertilization treatments caused little change in soil organic C (SOC) but a large variation in soil mineral composition. The whole-clay fraction (<5 μm) corresponded more to the fertilization treatment than the fine-clay fraction (<1 μm) in terms of percentage of illite peak area. The total percentage of vermiculite-chlorite peak area was significantly negatively correlated with the total percentage of illite peak area in the <5 μm soil particles (R=-0.946, P<0.0006). Different fertilization treatments gave significantly different results in K+ adsorption. The SOC oxidation test showed positive effects of SOC on K+ adsorption at lower K+ concentration ( 120 mg L-1) and negative effects at higher K+ concentration (240 mg L-1). The K+ adsorption by soil clay minerals after SOC oxidization accounted for 60-158% of that by unoxidized soils, suggesting a more important role of soil minerals than SOC on K+ adsorption. The K+ adsorption potential was significantly correlated to the amount of poorly crystallized illite present (R=0.879, P=0.012). The availability of adsorbed K+ for plant growth needs further study. | LIAO Yu-lin ZHENG Sheng-xian NIE Jun XIE Jian LU Yan-hong QIN Xiao-bo | 2013 | Journal of Integrative Agriculture2013，12，4： | 30 |
| 3 | Toxicity of cadmium and its competition with mineral nutrients for uptake by plants:A review显示文摘Cadmium(Cd)is a toxic heavy metal occurring in the environment naturally and is also generated through various anthropogenic sources and acts as a pollutant.Human health is affected by Cd pollution in farmland soils because food is the main source of Cd intake in the non-smoking population.For crops,Cd toxicity may result from a disturbance in uptake and translocation of mineral nutrients and disturbance in plant metabolism,inhibiting plant growth and development.However,plants have Cd tolerance mechanisms,including restricted Cd uptake,decreased Cd root-to-shoot translocation,enhanced antioxidant enzyme activities,and increased production of phytochelatins.Furthermore,optimal supply of mineral nutrients is one of the strategies to alleviate the damaging effects of Cd on plants and to avoid its entry into the food chain.The emerging molecular knowledge contributes to understanding Cd uptake,translocation,and remobilization in plants.In this review,Cd toxicity and tolerance mechanisms,agricultural practices to minimize Cd accumulation,Cd competition with essential elements(calcium,copper,iron,zinc,and manganese),and genes associated with Cd uptake are discussed in detail,especially regarding how these mineral nutrients and genes play a role in decreasing Cd uptake and accumulation in crop plants. | Shiyu QIN Hongen LIU Zhaojun NIE Zed RENGEL Wei GAO Chang LI Peng ZHAO | 2020 | Pedosphere2020，30，2： | 20 |
| 4 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 5 | Curculigoside isolated from Curculigo orchioides prevents hydrogen peroxide-induced dysfunction and oxidative damage in calvarial osteoblasts显示文摘反应的氧种类(ROS ) 包括 H2O2,在骨质疏松症的 pathophysiology 起一个关键作用。因此,能禁止 ROS 生产的代理人或抗氧化剂在骨质疏松症的治疗有高临床的价值。Curculigoside (杂种狗) ,酉分的混合物从 Curculigo orchioides Gaertn 的根茎孤立的主要 bioactive 之一,被报导有有势力抗氧化剂和 anti-osteoporotic 性质。然而,没有直接证据与观察 anti-osteoporotic 效果连接杂种狗的抗氧化剂能力,并且相关分子的机制仍然保持不清楚。因此,我们在 calvarial 造骨细胞对氧化应力调查了杂种狗的保护的效果并且讨论了相关机制。造骨细胞生存能力在 48-h 暴露以后显著地减少了到 H2O2 的 400 M,这被发现,与对待车辆的房间相比,并且 H2O2 的细胞毒素的效果显著地被颠倒什么时候有杂种狗的 0.110 M 的 pretreated (P < 0.05 ) 。有杂种狗的 0.110 M 的预告的处理减少了 ROS 生产和类脂化合物 peroxidation,并且增加了抗氧化剂酶的活动,例如 superoxide,在造骨细胞的 dismutase 和谷胱甘肽 peroxidase 由 H2O2 导致了。另外,象碱的磷酸酶,钙免职,和 Runx2 水平那样的区别标记的导致 H2O2 的减小显著地面对杂种狗被恢复。杂种狗也颠倒了细胞外的调整信号的 kinase 1/2,并且原子 factor-B 发信号和 p38 的抑制的导致 H2O2 的刺激激活 mitogen 的蛋白质 kinase 激活。这些结果通过减少 ROS 的生产提供新卓见进杂种狗的造骨细胞保护的机制,建议那条杂种狗可以作为为骨质疏松症和另外的骨头相关的人的疾病的预防和处理的一个对简历安全的代理人被开发。 | Ying Wang Lu Zhao Yin Wang Jinlong Xu Yah Nie Yuanhui Guo Yongtao Tong Luping Qin Qiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 15 |
| 6 | Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease显示文摘淀粉的(A) 肽长为 Alzheimer 的疾病(广告) 被看作了一个潜在的目标。A 的聚集在大脑织物的肽被相信是一个只病理学的过程。因此,与小分子堵住肽聚集的起始的阶段能为广告为新治疗的发展作为起点保持可观的诺言。在我们有毒的淀粉的汇编的理解的最近的快速的进步为这条有趣的途径提供一个新鲜动力。这里,我们在指向 A 肽讨论这些问题,挑战和新概念。 | Qin NIE Xiao-guang DU Mei-yu GENG | 2011 | Acta Pharmacologica Sinica2011，32，5： | 9 |
| 7 | Synergistic Flame-retardant Effect of Epoxy Resin Combined with Phenethyl-bridged DOPO Derivative and Graphene Nanosheets显示文摘Phenethyl-bridged DOPO derivative(DiDOPO)was combined with graphene nanosheets(GNSs)in epoxy resin(EP)to improve its flame retardancy.The results indicated that the introduction of only 1.5 wt%DiDOPO/1.5 wt%GNS in EP increased the limited oxygen index(LOI)from 21.8%to 32.2%,hence meeting UL 94 V-0 rating.The thermogravimetric analyses revealed that char yield rose in presence of GNSs to form thermally stable carbonaceous char.The decomposition and pyrolysis products in gas phase were characterized by thermogravimetry-Fourier transform infrared spectroscopy(TG-FTIR),and the release of large amounts of phosphorus was detected in the gas phase.The evaluation of flame-retardant effect by cone calorimetry demonstrated that GNSs improved the protective-barrier effect of fire residue of EP/DiDOPO/GNS.The latter was further confirmed by digital photography and scanning electron microscopy(SEM).Also,Raman spectroscopy showed that GNSs enhanced graphitization degree of the resin during combustion.Overall,the combination of DiDOPO with GNSs provides an effective way for developing high-performance resins with improved flame retardancy. | Wei Yan Ming-Qiu Zhang Jie Yu Sheng-Qiang Nie Dai-Qin Zhang Shu-Hao Qin | 2019 | Chinese Journal of Polymer Science2019，37，1： | 7 |
| 8 | Stress responsive gene CIPK14 is involved in phytochrome A-mediated far-red light inhibition of greening in Arabidopsis显示文摘In this study, we show that CIPK14,a stress responsive CBL-interacting protein kinase gene,is involved in phytochrome A-mediated far-red light inhibition of greening in Arabidopsis seedlings. The CIPK14-impairment mutant cipk14 grown in continuous far-red (FR) light did not show greening when exposed to white light illumination for 15 h. By contrast, the FR-grown phytochrome A null mutant phyA greened within 0.5 h of exposure to white light. Although greening of Col-4 (wild-type) was not completely abolished by FR, it exhibited a significantly decreased greening capacity compared with that of phyA. Further analyses demonstrated that the expression of protochlorophyllide reductase (POR) genes was correlated with the greening ability of the genotypes. In addition, CIPK14 appeared to be regulated by both the circadian clock and PhyA. Taken together, these results suggest that CIPK14 plays a role in PhyA-mediated FR inhibition of seedling greening, and that a Ca-related kinase may be involved in a previously undefined branch point in the phytochrome A signaling pathway. | QIN YuZhi2,3, GUO Ming1, LI Xu1, XIONG XingYao2,3, HE ChangZheng2,3, NIE XianZhou4 & LIU XuanMing1 1College of Life Science and Biotechnology, Hunan University, Changsha 410082, China 2College of Horticulture and Landscape, Hunan Agricultural University, Changsha 410128, China 3Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Changsha 410128, China 4Potato Research Centre, Agriculture and Agri-Food Canada, Fredericton, New Brunswick E3B 4Z7, Canada | 2010 | Science China(Life Sciences)2010，53，11： | 5 |
| 9 | Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory显示文摘Background:The outbreak of Ebola virus disease(EVD)in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus(EBOV)in 1976,and the countries most strongly affected were Sierra Leone,Guinea,and Liberia.Findings:The Sierra Leone-China Friendship Biological Safety Laboratory(SLE-CHN Biosafety Lab),a fixed Biosafety Level 3 laboratory in the capital city of Sierra Leone,was established by the Chinese government and has been active in EBOV detection since 11 March 2015.Complete management and program documents were created for the SLE-CHN Biosafety Lab,and it was divided into four zones(the green,yellow,brown,and red zones)based on the risk assessment.Different types of safe and appropriate personnel protection equipment(PPE)are used in different zones of the laboratory,and it fully meets the Biosafety Level 3 laboratory standards of the World Health Organization.Conclusion:Good preparedness,comprehensive risk assessment and operation documents,appropriate PPE,effective monitoring and intensive training,together with well-designed and reasonable laboratory sectioning are essential for guaranteeing biosafety. | Qin Wang Wei-Min Zhou Yong Zhang Huan-Yu Wang Hai-Jun Du Kai Nie Jing-Dong Song Kang Xiao Wen-Wen Lei Jian-Qiang Guo He-Jiang Wei Kun Cai Yan-Hai Wang Jiang Wu Gerard Kamara Idrissa Kamara Qiang Wei Mi-Fang Liang Gui-Zhen Wu Xiao-Ping Dong | 2016 | Infectious Diseases of Poverty2016，5，1： | 5 |
| 10 | Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP显示文摘胸腺嘧啶 DNA glycosylase (TDG ) ,开始 G/T 和 G/U 的修理的酶错配,最近被发现 crucialin 胚胎维持 epigenetic 稳定性并且便于活跃 DNA demethylation 的开发。这里,我们在作为 -catenin/TCFs 建筑群的 transcriptional 激活剂发信号的 Wnt 报导 TDG 的 novelrole。我们 TDG 绑在 thetranscriptional 因素家庭 LEF1/TCFs 并且加强的数据表演 -catenin/TCFs transactivation,当 TDG 弄空压制 Wnt3a-stimulatedreporter 活动或目标基因抄写时。下次,我们显示出那 CBP,已知的激活剂,也为在目标倡导者上形成合作建筑群的 TDG functionthrough 被要求。而且,有在人的冒号 cancertissue 的 TDG 层次的举起,并且 TDG 击倒禁止冒号房间的增长。总的来说,我们的结果表明作为新激活剂, TDG 支持 -catenin/TCFs transactivation 并且机能上地在正规 Wnt 发信号与 CBP 合作。 | Yingying Jia Fen Nie Aiying Du Zhangcheng Chen Yuanbo Qin Tao Huang Xiaomin Song Lin Li | 2014 | Journal of Molecular Cell Biology2014，8，3： | 5 |
| 11 | Fingerprinting 146 Chinese chestnut(Castanea mollissima Blume)accessions and selecting a core collection using SSR markers显示文摘Chinese chestnut is an important nut tree around the world.Although the types of Chinese chestnut resources are abundant,resource utilization and protection of chestnut accessions are still very limited.Here,we fingerprinted and determined the genetic relationships and core collections of Chinese chestnuts using 18 fluorescently labeled SSR markers generated from 146 chestnut accessions.Our analyses showed that these markers from the tested accessions are highly polymorphic,with an average allele number(N_(a))and polymorphic information content(PIC)of 8.100 and 0.622 per locus,respectively.Using these strongly distinguishing markers,we successfully constructed unique fingerprints for 146 chestnut accessions and selected seven of the SSR markers as core markers to rapidly distinguish different accessions.Our exploration of the genetic relationships among the five cultivar groups indicated that Chinese chestnut accessions are divided into three regional type groups:group I(North China(NC)and Northwest China(NWC)cultivar groups),group II(middle and lower reaches of the Yangtze River(MLY)cultivar group)and group III(Southeast China(SEC)and Southwest China(SWC)cultivar groups).Finally,we selected 45 core collection members which represent the most genetic diversity of Chinese chestnut accessions.This study provides valuable information for identifying chestnut accessions and understanding the phylogenetic relationships among cultivar groups,which can serve as the basis for efficient breeding in the future. | NIE Xing-hua WANG Ze-hua LIU Ning-wei SONG Li YAN Bo-qian XING Yu ZHANG Qing FANG Ke-feng ZHAO Yong-lian CHEN Xin WANG Guang-peng QIN Ling CAO Qing-qin | 2021 | Journal of Integrative Agriculture2021，20，5： | 5 |
| 12 | Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage显示文摘一个快速、绿、高度敏感的 excitationemission 矩阵(EEM ) 荧光方法在在秒顺序优点的帮助下包括 uncalibrated 干扰的人的血浆和尿样品的生物液体为 irinotecan (CPT-11 ) 的分析被建议。由于从生物矩阵,平行因素分析(PARAFAC ) 并且轮流出现的严肃的光谱的重叠正规化加权的错误(ANWE ) 被建议了直接执行刻度并且克服有麻烦做传统的 fluorospectrophotometer 的问题。令人满意的结果能被完成。而且,建议方法的性能基于优点和一些统计参数的数字被评估。两个算法的精确性被椭圆的联合信心区域(EJCR ) 验证测试。精确和重覆性被 intra 天的相对标准差(RSD ) 也调查并且内部天。 | Hai Yan Fu Hai Long Wu Jin Fang Nie Yong Jie Yu Hong Yan Zou Ru Qin Yu | 2010 | Chinese Chemical Letters2010，21，12： | 5 |
| 13 | An Efficient Multi-hop Broadcast Protocol for Emergency Messages Dissemination in VANETs显示文摘Black-burst based multi-hop broadcast protocols are effective means to disseminate Emergency messages(EMs)in Vehicular ad hoc networks(VANETs).However,Clear to broadcast(CTB)collision will happen and reduce propagation speed.Aiming at this problem,we propose a Black-burst and multi-channel based multihop broadcast(BMMB)protocol.Vehicles with multiple antennas can transmit and sense black-burst at different channels simultaneously based on multi-channel technology.Compared with existing black-burst based methods,BMMB shortens the iterative procedure to find out the optimal segment.Only one relay vehicle can be rapidly selected within the optimal segment without CTB collision.BMMB enables alternative broadcast methods,i.e.,unidirectional broadcast and multi-directional broadcast for straight roads and intersections respectively.Theoretical analysis is done for performance evaluation of BMMB,and simulation results demonstrate that BMMB performs better in terms of average one-hop delay and propagation speed. | WU Libing NIE Lei FAN Jing HE Yanxiang LIU Qin WU Dan | 2017 | Chinese Journal of Electronics2017，26，3： | 4 |
| 14 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 15 | Triboelectric nanogenerator enhanced multilayered antibacterial nanofiber air filters for efficient removal of ultrafine particulate matter显示文摘我们开发了 multilayered 抗菌剂 polyimide (PI ) nanofiber 空气为把极其细小的微粒物质(下午) 从周围的空气移开过滤的提高的高效率的旋转摩擦电 nanogenerator (R-TENG ) 。比作单人赛分层的 PI nanofiber 过滤器, multilayered nanofiber 过滤器能完全与比 0.54 m 大的直径粒子移开所有,表演为更小的下午粒子提高移动效率。在与 aR-TENG 连接以后,为极其细小的粒子的 filer 的移动效率进一步被提高。为极其细小的微粒物质的最高的移动效率在 53.3 nm 的直径是 94.1% ,平均移动效率到达 89.9% 。尽管有层数字的增加,这部电影的每单个层的厚度减少了,并且因此,过滤器的全部的压力落下减少了而不是增加。而且,因为银 nanoparticles 的小数量的增加, nanofiber 电影展出了高抗菌剂活动。有零个臭氧版本和低压力落下的这种技术为清洗空气,薄雾处理,和细菌的控制是适当的。 | Guang Qin Gu Chang Bao Han Jing Jing Tian Tao Jiang Chuan He Cun Xin Lu Yu Bai Jin Hui Nie Zhou Li Zhong Lin Wang | 2018 | Nano Research2018，11，8： | 4 |
| 16 | Curcumin protects against acetaminophen-induced apoptosis in hepatic injury显示文摘AIM:To explore the effects of curcumin(CMN)on hepatic injury induced by acetaminophen(APAP)in vivo.METHODS:Male mice were randomly divided into three groups:groupⅠ(control)mice received the equivalent volumes of phosphate-buffered saline(PBS)intraperitoneally(ip);GroupⅡ[APAP+carboxymethylcellulose(CMC)]mice received 1%CMC(vehicle)2h before APAP injection;GroupⅢ(APAP+CMN)mice received curcumin(10 or 20 mg/kg,ip)2 h before before or after APAP challenge.In GroupsⅡandⅢ,APAP was dissolved in pyrogen-free PBS and injected at a single dose of 300 mg/kg.CMN was dissolved in 1%CMC.Mice were sacrificed 16 h after the APAP injection to determine alanine aminotransferase(ALT)levels in serum and malondialdehyde(MDA)accumulation,superoxide dismutase(SOD)activity and hepatocyte apoptosis in liver tissues.RESULTS:Both pre-and post-treatment with curcumin resulted in a significant decrease in serum ALT compared with APAP treatment group(10 mg/kg:801.46±661.34 U/L;20 mg/kg:99.68±86.48 U/L vs 5406.80±1785.75 U/L,P<0.001,respectively).The incidence of liver necrosis was significantly lowered in CMN treated animals.MDA contents were significantly reduced in 20 mg/kg CMN pretreatment group,but increased in APAP treated group(10.96±0.87 nmol/mg protein vs 16.03±2.58 nmol/mg protein,P<0.05).The decrease of SOD activity in APAP treatment group and the increase of SOD in 20 mg/kg CMN pretreatment group were also detected(24.54±4.95 U/mg protein vs 50.21±1.93 U/mg protein,P<0.05).Furthermore,CMN treatment efficiently protected against APAPinduced apoptosis via increasing Bcl-2/Bax ratio.CONCLUSION:CMN has significant therapeutic potential in both APAP-induced hepatotoxicity and other types of liver diseases. | Gang Li Jun-Bao Chen Chao Wang Zhi Xu Hao Nie Xiao-Yan Qin Xiao-Mei Chen Quan Gong | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 17 | 断肢再植术后感染患者甲襞微循环及血流指标的变化观察显示文摘目的分析断肢再植术后感染患者甲襞微循环及血流变指标的变化,为断肢再植术后感染患者的诊治及预防控制提供依据。方法选取2012年1月-2015年9月收治的56例断肢再植术后感染患者为观察组,同时间段56例断肢再植术后未发生感染患者为对照组,将两组患者的甲襞微循环及血流变指标进行检测与比较,并比较观察组中浅层感染及深部感染者的检测结果。结果观察组甲襞微循环加权积分中的襻周积分、流态积分、管襻积分及总积分分别为(1.64±0.21)、(2.31±0.27)、(1.25±0.14)及(3.32±0.32),其均高于对照组(0.88±0.12)、(1.18±0.15)、(0.64±0.06)及(2.30±0.24),其他甲襞微循环指标及血流变指标也均高于对照组,且观察组中深部感染患者的检测结果高于浅层感染的患者,各个比较指标间差异均有统计学意义(P<0.05)。结论断肢再植术后感染患者甲襞微循环及血流变指标均较高,且浅部感染与深部感染患者的检测结果也存在明显差异,因此应重视对此类患者进行微循环状态的改善。 | 张全英 朱玉花 李琼 李中锋 王丽娜 NIE Xing-guo QIN Hua | 2016 | 中华医院感染学杂志2016，26，13： | 4 |
| 18 | Comparison of Composition and Diversity of Bacterial Microbiome in Human Upper and Lower Respiratory Tract显示文摘 | Zhi-Hong Feng Qin Li Si-Ran Liu Xiao-Nan Du Chen Wang Xiu-Hong Nie Wei Wang Sun Ying | 2017 | Chinese Medical Journal2017，，9： | 4 |
| 19 | C-reactive protein as a predictor of malignant ventricular arrhythmias in non-ST elevation myocardial infarction显示文摘Objective To investigate whether C-reactive protein (CRP) is a biomarker of malignant ventricular arrhythmias (MVA) occurring in non-ST elevation myocardial infarction (NSTEMI) patients with Global Registry of Acute Coronary events (GRACE) scores < 140. Methods A total of 1450 NSTEMI patients were included in this study. Hs-CRP blood levels were measured via a turbidimetric immunoassay after confirming the diagnosis of NSTEMI with GRACE scores < 140. Results Consistent with prior studies, the MVA occurrence rate in our cohort was 6.7%, and patients with MVA exhibited a reduced left ventricular ejection fraction (46.1%± 6.9% vs. 61.5%± 8.7%, P = 0.032), a higher incidence of Killip classification > 1 (34.1% vs. 24.2%, P < 0.001), an increased surgical revascularization rate (34.1% vs. 9.7%, P < 0.001), and increased mortality (16.5% vs. 5.8%, P < 0.001). Serum hs-CRP levels were higher (P = 0.003) in NSTEMI patients with MVA, and this increase appeared unrelated to other clinical parameters. The C-statistic to discriminate MVA was 0.82 (95% CI: 0.74–0.89). Using receiver operating characteristics analysis, we optimized a cutoff point of 16 mL/L, and the sensitivity and specificity were 95% and 61%, respectively;the positive predictive value was 20% and the negative predictive value was 99%. Conclusions An hs-CRP assay is a potential MVA biomarker in low-risk NSTEMI patients with GRACE scores < 140. If validated in prospective studies, hs-CRP may offer a low-cost supplementary strategy for risk stratification for NSTEMI patients. | Cheng-Gang WANG Xiu-Chuan QIN Shao-Ping NIE Chun-Mei WANG Hui AI Bin QUE | 2019 | Journal of Geriatric Cardiology2019，16，8： | 4 |
| 20 | Innovative Design and Performance Evaluation of a High-speed Bionic Mechanical Leg显示文摘 | Hua Nie Ronglei Sun Chaoke Guo Guohua Qin Huiyang Yu | 2015 | Journal of Bionic Engineering2015，12，3： | 3 |
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