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| 1 | On-Line Fault Diagnosis and Fault-Tolerant Operation of Modular Multilevel Converters –A Comprehensive Review显示文摘Modular multilevel converters(MMCs)have been one of the most broadly used multilevel converter topologies in industrial applications,particularly in medium-voltage motor drives and high-voltage dc power conversion systems.However,due to the utilization of large amount of semiconductor devices,the reliability of MMCs becomes one of the severe challenges constraining their further development and applications.In this paper,common electrical faults of the MMC have been summarized and analyzed,including open-circuit switching faults,short-circuit switching faults,dc-bus short-circuit faults,and single line-to-ground faults on the ac side.A thorough and comprehensive review of the existing online fault diagnostic methods has been conducted.In addition,fault-tolerant operation strategies for such various fault scenarios in MMCs have been presented.All the fault diagnosis and fault-tolerant operation strategies are comparatively evaluated,which aims to provide a state-of-the-art reference on the MMC reliability for future research and industrial applications. | JiangBiao He Qichen Yang Zheng Wang | 2020 | CES Transactions on Electrical Machines and Systems2020，4，4： | 9 |
| 2 | Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis显示文摘Ginsenoside Rh2,which is extracted from ginseng,exerts antitumor activity.Recent studies suggest that Rh2 may suppress the growth of colon cancer(CC)in vitro.However,the underlying mechanism remains unclear.In this study,we identified the relative levels of miR-150-3p in CC tissues and cells by a comprehensive strategy of data mining,computational biology,and real-time reverse transcription PCR(qRT-PCR)experiments.The regulatory effects of miR-150-3p/SRCIN1 on the proliferative and invasive abilities of CC cells are evaluated by CCK-8,EdU,wound healing,and transwell assays.Cell cycle-and apoptosis-related protein levels are assessed by western blot analysis.An in vivo tumor formation assay was conducted to explore the effects of miR-150-3p on tumor growth.Furthermore,bioinformatics and dual luciferase reporter assays are applied to determine the functional binding of miRNA to mRNA of the target gene.Finally,the relationship between Rh2 and miR-150-3p was further verified in SW620 and HCT-116 cells.miR-150-3p is downregulated in CC tissues and cell lines.Functional assays indicate that the upregulation of miR-150-3p inhibits tumor growth both in vivo and in vitro.In addition,SRCIN1 is upregulated in CC and predicts a poor prognosis,and it is the direct target for miR-150-3p.Moreover,the miR-150-3p mimic decreases Topflash/Fopflash-dependent luciferase activity,resulting in the inhibition of Wnt pathway activity.Rh2 can suppress the growth of CC by increasing miR-150-3p expression.Rh2 alleviates the accelerating effect on Wnt pathway activity,cell proliferation/migration,and colony formation caused by miR-150-3p inhibition.Rh2 inhibits the miR-150-3p/SRCIN1/Wnt axis to suppress colon cancer growth. | Shipeng Li Wenfeng Han Qichen He Yang Wang Gang Jin Youcheng Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 2 |
| 3 | Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity显示文摘Dear Editor,Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers. | Guangya Zhu Jingjinq Xie Zhenzhen Fu Mingliang Wang Qichen Zhang Hao He Zijun Chen Xin Guo Jidong Zhu | 2021 | Cell Research2021，31，9： | 2 |
| 4 | Oxygen-rich carbon-nitrogen quantum dots as cocatalysts for enhanced photocatalytic H_2 production activity of TiO_2 nanofibers显示文摘We developed an one-step hydrothermal method to synthesize carbon-nitrogen quantum dots(CNQDs) with oxygen-rich functional groups.The sample was characterized by TEM,AFM,FT-IR,XPS,UV-vis absorption and PL spectra.The 0/C and N/C atomic ratio of typical CNQDs with diameters of 3-6 nm are ca.0.4 and 0.2,respectively.Without noble metal cocatalyst,the photocatalytic H_2 production rate of CNQDs/TiO_2 nanofibers(NFs)(112.4 μmol h^(-1) g^(-1)) is 1.8 times higher than that of TiO_2 NFs.The good absorption of light contributes to the enhanced photocatalytic H_2 performance.The CNQDs could be promising in biomedical imaging,optical data recording storage and photo/electrocatalysis,etc. | Zhiyan Chen Yishang Wu Qichen Wang Zhiyong Wang Lihua He Yongpeng Lei Zhongmin Wang | 2017 | Progress in Natural Science:Materials International2017，27，3： | 1 |
| 5 | Nephrocyte-neurocyte interaction and cellular metabolic analysis on membrane-integrated microfluidic device显示文摘Cell-cell interaction and cell metabolic analysis provide new opportunities for better understanding of critical biochemical processes. Advanced microfluidic technologies enable to create more realistic in vitro microenvironment by spatial and temporal control of cell growth and co-culture. In this work, we design a microfluidic device to achieve the co-culture of PC12 cells and 293 cells, and study in vitro cell-cell interaction via cell metabolic analysis by mass spectrometry. The membraneintegrated microfluidic device was firstly used for cell co-culture, and the cellular metabolite was further investigated by mass spectrometer(MS). Our results showed that the differentiation of PC12 cells could be successfully induced by m NGF and also greatly influenced by the microchannel treatment of fetal bovine serum(FBS) solution. The identification of cell morphology, microtubule-associated protein 2(MAP-2) expression and viability of differentiated PC12 cells were conducted before 293 cells being introduced into the top microfluidic channels and stimulated to secrete cell metabolism products. The developed microfluidic device is a potentially useful tool for high throughput of cell-cell interaction study. | Qichen Zhuang Shiqi Wang Jie Zhang Ziyi He Haifang Li Yuan Ma Jin-Ming Lin | 2016 | Science China Chemistry2016，59，2： | 1 |
| 6 | Efficient Entity Relation Discovery on Web显示文摘 | He Jing Liu Yuan Tu Qichen | 2007 | Journal of Computational Information Systems2007，3，2： | 1 |
| 7 | Potential active sites of Mo single atoms for electrocatalytic reduction of N_(2)显示文摘Single atom catalysts(SACs) with isolated metal atoms dispersed on supports exhibit distinctive performances for electrocatalysis reactions.The designable realization of well-dispersed single metal atoms is still a great challenge owing to their ease of aggregation.Here,Mo single atomic sites(Mo-N_(3)C)combined with some ultrasmall Mo_(2)C/MoN clusters(Mo-SA/Mo_(2)C-MoN-Cs,mean diameter <2 nm) on nitrogen-doped porous carbon were synthesized via a simple pyrolysis of bimetallic Zn/Mo metalorganic frameworks.X-ray absorption near edge spectra(XANES) in combination with various characterizations show that most of Mo species in sample exist in the form of single sites and the exact structure is Mo-N_(3)C.Density functional theory(DFT) calculation further shows that as the number of Ncoordination in the Mo-NxC moieties increases,the positive cha rge of Mo atoms increases.The single Mo atoms in Mo-N_(3)C have the best capability of N_(2) adsorption,which may serve as main active sites for further electrochemical N2 reduction. | Lei Chen Chaozheng He Ran Wang Qian Li Jian Zeng Wei Liu Yuchao Wang Qichen Wang Tong Ye Yougen Tang Yongpeng Lei | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 8 | A reference-grade genome assembly for Astragalus mongholicus and insights into the biosynthesis and high accumulation of triterpenoids and flavonoids in its roots显示文摘Astragalus membranaceus var.mongholicus(AMM),a member of the Leguminosae,is one of the most important medicinal plants worldwide.The dried roots of AMM have a wide range of pharmacological effects and are a traditional Chinese medicine.Here,we report the first chromosome-level reference genome of AMM,comprising nine pseudochromosomes with a total size of 1.47 Gb and 27868 protein-encoding genes.Comparative genomic analysis reveals that AMM has not experienced an independent wholegenome duplication(WGD)event after the WGD event shared by the Papilionoideae species.Analysis of long terminal repeat retrotransposons suggests a recent burst of these elements at approximately 0.13 million years ago,which may explain the large size of the AMM genome.Multiple gene families involved in the biosynthesis of triterpenoids and flavonoids were expanded,and our data indicate that tandemduplication has been the main driver for expansion of these families.Among the expanded families,the phenylalanine ammonia-lyase gene family was primarily expressed in the roots of AMM,suggesting their roles in the biosynthesis of phenylpropanoid compounds.The functional versatility of 2,3-oxidosqualene cyclase genes in cluster Ⅲ may play a critical role in the diversification of triterpenoids in AMM.Our findings provide novel insights into triterpenoid and flavonoid biosynthesis and can facilitate future research on the genetics and medical applications of AMM. | Yi Chen Ting Fang He Su Sifei Duan Ruirui Ma Ping Wang Lin Wu Wenbin Sun Qichen Hu Meixia Zhao Lianjun Sun Xuehui Dong | 2023 | Plant Communications2023，4，2： | 0 |
| 9 | One-step hydrothermal synthesis of Cit-NaYbF_(4):Er^(3+)nanocrystals with enhanced red upconversion emission for in vivo fluorescence molecular tomography显示文摘Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical studies.In this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modifiedα-NaYbF_(4):2%Er^(3+)nanocrystals was proposed.The introduction of various doping ions into NaYbF_(4):2%Er^(3+)and the different valence states of the same ions affect both the crystal size and upconversion luminesce nce.There fore,we investigated the upconversion luminesce nce enha ncement of NaYbF_(4):2%Er^(3+)by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol%Fe^(2+)ions shows the greatest enhancement,especially for red emission at654 nm.Furthermore,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detectio n.Confocal laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF_(4):2%Er/5%Fe^(2+)leads to a clear outline and improves visualization of the cell morphology.In addition,the CA coated NaYbF_(4):2%Er^(3+)/5%Fe^(2+)nanoparticles and NaYbF_(4):2%Er^(3+)/5%Fe^(2+)show low cytotoxicity in HeLa cells.Organ imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and spleen.Together,these results indicate that the Cit-NaYbF_(4):2%Er^(3+)/5%Fe^(2+)UCNPs are efficient nanoprobes for fluorescence molecular to mography. | Xiaoli Luo Qichen Chen Hongbo Guo Heng Zhang Xiaowei He Wu Zhao | 2024 | Journal of Rare Earths2024，42，1： | 0 |
| 10 | Chinese expert consensus on multidisciplinary diagnosis and treatment of pancreatic neuroendocrine liver metastases显示文摘Many management strategies are available for pancreatic neuroendocrine neoplasms with liver metastases.However,a lack of biological,molecular,and genomic information and an absence of data from rigorous trials limit the validity of these strategies.This review presents the viewpoints from an international conference consisting of several expert working groups.The working groups reviewed a series of questions of particular interest to clinicians taking care of patients with pancreatic neuroendocrine neoplasms with liver metastases by reviewing the existing management strategies and literature,evaluating the evidence on which management decisions were based,developing internationally acceptable recommendations for clinical practice,and making recommendations for clinical and research endeavors.The review for each question will be followed by recommendations from the panel. | Yihebali Chi Liming Jiang Susheng Shi Shun He Chunmei Bai Dan Cao Jianqiang Cai Qichen Chen Xiao Chen Yiqiao Deng Shunda Du Zhen Huang Li Huo Yuan Ji Jie Li Wenhui Lou Jie Luo Xueying Shi Lijie Song Bei Sun Huangying Tan Feng Wang Xuan Wang Zhewen Wei Wenming Wu Dianrong Xiu Jianming Xu Huadan Xue Yi Yang Fei Yin Chunhui Yuan Yefan Zhang Weixun Zhou Dongbing Zhao Hong Zhao | 2023 | Journal of Pancreatology2023，6，4： | 0 |
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