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| 1 | Early vs late endoscopic retrograde cholangiopancreatography in patients with acute cholangitis: A nationwide analysis显示文摘AIM To assess the effect of early vs late endoscopic retrograde cholangiopancreatography(ERCP) on mortality and readmissions in acute cholangitis, using a nationally representative sample.METHODS We used the 2014 National Readmissions Database to identify adult patients hospitalized with acute cholangitis who underwent therapeutic ERCP within one week of admission. Early ERCP was defined as ERCP performed on the same day of admission or the next day(days 0 or 1, < 48 h), and late ERCP was performed on days 2 to 7 of admission. Patients with severe cholangitis had any of the following additional diagnoses: Severe sepsis, septic shock, acute renal failure,acute respiratory failure, or thrombocytopenia. Multivariate logistic regression was used to calculate the adjusted odds of association of ERCP timing with inhospital mortality, 30-d mortality, and 30-d readmissions, controlling for age, sex,severe disease and comorbidities.RESULTS Four thousand five hundred and seventy patients satisfied the inclusion criteria;with a mean age of 64.1 years. Of these, 66.6% had early ERCP, while 33.4% had late ERCP. Early ERCP was associated with lower in-hospital mortality [1.2% vs2.4%, adjusted odds ratio(aOR) = 0.50, 95%CI: 0.76-0.83, P = 0.001] and lower 30-d mortality(1.5% vs 3.3%, aOR = 0.48, 95%CI: 0.33-0.69, P < 0.0001) compared to the late ERCP group. Similarly, early ERCP was associated with lower 30-d readmissions(9.7% vs 15.1%, aOR = 0.58, 95%CI: 0.49-0.7, P < 0.0001). When stratified by severity of cholangitis, there was a similar benefit of early ERCP on all outcomes in those with and without severe cholangitis. The mean length of stay was higher in the late ERCP group compared to the early ERCP group(6.9 d vs 4.5 d, P < 0.0001). The mean hospitalization cost was higher in the late ERCP group($21459 vs $16939, P < 0.0001).CONCLUSION Early ERCP is associated with lower in-hospital and 30-d mortality in those with or without severe cholangitis. Regardless of severity, we suggest performing early ERCP. | Ramzi Mulki Rushikesh Shah Emad Qayed | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，1： | 8 |
| 2 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 3 | Esophagogastric junction outflow obstruction: Where are we now in diagnosis and management?显示文摘Esophagogastric junction outflow obstruction(EGJOO) is a major motility disorder based on the Chicago Classification of esophageal motility disorders.This entity involves a heterogenous group of underlying etiologies. The diagnosis is reached by performing high-resolution manometry. This reveals evidence of obstruction at the esophagogastric junction, manifested by an elevated integrated relaxation pressure(IRP) above a cutoff value(IRP threshold varies by the manometric technology and catheter used), with preserved peristalsis. Further tests like endoscopy, timed barium esophagram, and cross-sectional imaging can help further elucidate the underlying etiology and rule out mechanical causes.Treatment is tailored to the underlying cause. Similar to achalasia, treatment targeting lower esophageal sphincter disruption like pneumatic dilation, peroral endoscopic myotomy, and botulinum injection are used in patients with functional EGJOO and persistent symptoms. | Salih Samo Emad Qayed | 2019 | World Journal of Gastroenterology2019，25，4： | 2 |
| 4 | Toxicity of copper(II) ions to microorganisms in biological wastewater treatment systems显示文摘 | Valeria Ochoa-Herrera Glendy León Qais Banihani Jim A. Field Reyes Sierra-Alvarez | 2011 | Science of the Total Environment2011，，： | 2 |
| 5 | BMP2 promotes differentia- tion of nitrergic and catecholaminergie enteric neurons through a Smadl-dependent pathway显示文摘 | Anitha M Shahnavaz N Qayed E | 2010 | Am J Physiol Gastrointest Liver Phys- iol2010，298，3： | 1 |
| 6 | Toxicity of copper(II) ions to microorganisms in biological wastewater treatment systems显示文摘 | Valeria Ochoa-Herrera Glendy León Qais Banihani Jim A. Field Reyes Sierra-Alvarez | 2011 | Science of the Total Environment2011，，： | 1 |
| 7 | Nitrate and nitrite inhibition of methanogenesis during denitrification in granular biofilms and digested domestic sludges显示文摘 | Qais Banihani Reyes Sierra-Alvarez James A. Field | 2009 | Biodegradation2009，，6： | 1 |
| 8 | Relative Defects in Mucosal Immunity Predict Acute Graft-Versus-Host Disease 显示文摘 | August KJ Chiang KY Qayed M | 2014 | Biol Blood Marrow Transplant2014，20，7： | 1 |
| 9 | The kidney papilla is a stem cells niche显示文摘 | Qais Al-Awqati Juan A. Oliver | 2006 | Stem Cell Reviews2006，，3： | 1 |
| 10 | Lower gastrointestinal hemorrhage显示文摘 | Qayed E Dagar G Nanchal RS | 2016 | Crit Care Clin2016，32，： | 1 |
| 11 | Iri- ontecan as maintenance therapy in high-risk hepatoblastoma 显示文摘 | Qayed M Powell C Moran ER Hangen M Katzenstein HM | 2010 | Pediatr Blood Cancer2010，54，5： | 1 |
| 12 | BMP2 promotes differentiation of nitrergic and catecholaminergic enteric neurons through a Smad1-dependent pathway显示文摘 | Anitha M Shahnavaz N Qayed E | | 0，，03： | 1 |
| 13 | BMP2 promotes differentiation of nitrergic and catecholaminergic enteric neurons through a Smadl-dependent pathway显示文摘 | Anitha M Shahnavaz N Qayed E | | 0，，3： | 1 |
| 14 | Segmental expression of notch and hairy genes in nephrogenesis 显示文摘 | Linghong C Qais A | 2005 | Am J Physiol Renal Physiol2005，288，5： | 1 |
| 15 | Almutiple image encryption and water-marking by random phase matching显示文摘 | He M Z Qai L Z Liu Q | 2005 | Optics2005，247，712： | 1 |
| 16 | Cholecystectomy for asymptomatic gallstones:Markov decision tree analysis显示文摘Gallstones are a common public health problem,especially in developed countries.There are an increasing number of patients who are diagnosed with gallstones due to increasing awareness and liberal use of imaging,with 22.6%-80% of gallstone patients being asymptomatic at the time of diagnosis.Despite being asymptomatic,this group of patients are still at life-long risk of developing symptoms and complications such as acute cholangitis and acute biliary pancreatitis.Hence,while early prophylactic cholecystectomy may have some benefits in selected groups of patients,the current standard practice is to recommend cholecystectomy only after symptoms or complications occur.After reviewing the current evidence about the natural course of asymptomatic gallstones,complications of cholecystectomy,quality of life outcomes,and economic outcomes,we recommend that the option of cholecystectomy should be discussed with all asymptomatic gallstone patients.Disclosure of material information is essential for patients to make an informed choice for prophylactic cholecystectomy.It is for the patient to decide on watchful waiting or prophylactic cholecystectomy,and not for the medical community to make a blanket policy of watchful waiting for asymptomatic gallstone patients.For patients with high-risk profiles,it is clinically justifiable to advocate cholecystectomy to minimize the likelihood of morbidity due to complications. | Brian Juin Hsien Lee Qai Ven Yap Jee Keem Low Yiong Huak Chan Vishal G Shelat | 2022 | World Journal of Clinical Cases2022，10，29： | 1 |
| 17 | Antibacterial flavonoids from Desmos chinensis 显示文摘 | Qais N Rahman MM Rashid MA | 1996 | Fitoterapia1996，67，6： | 1 |
| 18 | R-loop: 染色质动力学的一个新兴的管理者显示文摘染色质的动态结构,它处于二个 conformational 状态存在:heterochromatin 和 euchromatin,在抄写,复制,再结合,和 DNA 损坏修理期间改变 DNA 的 theaccessibility 到规章的因素。histones 和 DNA 的 Chemicalmodifications,以及腺苷改变的 triphospahate 依赖的 nucleosome,是关于在过去的二十年的染色质动力学的研究的 majorfocus。然而,用 DNA-RNA hybrid-specificantibody 的最近的研究和下一代的定序途径表明了 R 环的形成,最普通的 non-canonicalDNA 之一组织,是染色质状态的一个新兴的管理者。这评论在正常和疾病状态集中于最近的卓见进相互影响 betweenR 环形成和染色质的 epigenetic 修正。 | Qais AI-Hadid Yanzhong Yang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，7： | 1 |
| 19 | Removal of acid red and sodium chloride mixtures from aqueous solutions using nanofiltration 显示文摘 | MOHAMED A A QAIS B A SHAKER H | 2007 | Desalination2007，206，： | 1 |
| 20 | Apoptosis in metanephric development 显示文摘 | Chizuko Koseki Doris Herzlinger and Qais AL-Awqati | 1992 | The Journal of Cell Biology1992，119，5： | 1 |
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