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| 1 | New geological evidence of crustal thickening in the Gangdese block prior to the Indo-Asian collision显示文摘Recent mapping in the Gangdese block has revealed many leucogranites that are similar to those in the High Himalaya. These leucogranites formed at ~140 Ma as indicated by monazite Th-Pb ion-microprobe dating and cooled at ~130 Ma as indicated by muscovite 40Ar/39Ar dating. In conjunction with previous structural and paleogeographic studies, the new data indicate that the Gangdese block underwent crustal thickening and associated exhumation during ~140-130 Ma. In this regard, the southern margin of Eurasia continent was comparable to the modern South American Altiplano-Puna plateau, the prime example of active ocean-continent subduction and associated thickened crust. Specifically, the early stages of crustal thickening and uplifting of the Gangdese block may result from subduction of the Neo-Tethyan Ocean. If the Tibetan Plateau would form by accretion of a series of blocks with thickened crust, an elevated topographic plateau similar to the Altiplano- Puna plateau had formed before collision between the Indian and Eurasian plates. Then the Tibetan Plateau would have quickly thickened, uplifted, and begun to extend soon after onset of the collision. Thus, the deformational mechanism of the Tibetan Plateau is not distributed shortening, but rather concentrating deformation within regions of thin crust between the accreted blocks. | DING Lin & LAI Qingzhou Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Correspondence should be addressed to Ding Lin (e-mail: dinglin@ mail.igcas.ac.cn) | 2003 | Chinese Science Bulletin2003，48，15： | 73 |
| 2 | Constraining the stepwise migration of the eastern Tibetan Plateau margin by apatite fission track thermochronology显示文摘Granites sampled from Garzê-Litang thrust, Longmen Shan thrust, Garzê and Litang strike-slip faults in the eastern Tibetan Plateau have been analyzed with apatite fission track thermochronological method in this study. The measured fission track apparent ages, combined with the simulated annealing mod- eling of the thermal history, have been used to reconstruct the thermal evolutionary histories of the samples and interpret the active history of the thrusts and faults in these areas. Thermal history mod- eling shows that earlier tectonic cooling occurred in the Garzê-Litang thrust in Miocene (~20―16 Ma) whereas the later cooling occurred mainly in the Longmen Shan thrust since ~5 Ma. Our study sug- gests that the margin of eastern Tibetan Plateau was extended by stages: through strike-slip faults deformations and related thrusts, the upper crust formed the Garzê-Litang margin in the Miocene epoch and then moved to the Longmen Shan margin since ~5 Ma. During this process, the deformations of different phases in the eastern Tibetan Plateau were absorbed by the thrusts within them and conse- quently the tectonic events of long-distance slip and extrusion up to hundreds of kilometers have not been found. | LAI QingZhou DING Lin WANG HongWei YUE YaHui CAI FuLong | 2007 | Science China Earth Sciences2007，50，2： | 24 |
| 3 | DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling显示文摘endoplasmic 蜂窝胃(嗯) 由原子信封, perinuclear 表和一个外部管状的网络组成。外设嗯并且线粒体形式在特定的子域的紧密的接触,它协调二个细胞器的函数并且为象 Ca 2+ 转移和 apoptosis 那样的多重细胞的进程被要求。然而,它大部分是未知的怎么嗯形态学并且嗯线粒体发信号动态地在象 DNA 那样的不同生理或病理学的条件下面被调整损坏。这里,我们证明外设,管状嗯响应 DNA 经历重要扩展损坏,和那这个过程依赖于嗯塑造蛋白质 REEP1, REEP2 和 EI24 (别名 PIG8 ) 的调停 p53 的 transcriptional 激活。这通过 EI24 和 mitochondrial 支持嗯线粒体接触的形成外部膜蛋白质 VDAC2,便于 Ca 2+ 转移从嗯到线粒体并且支持 DNA 导致损坏的 apoptosis。因此,我们识别包含改变在的一条唯一的 DNA 损坏反应小径嗯形态学,发信号的嗯线粒体,和 apoptosis。 | Pengli Zheng Qingzhou Chen Xiaoyu Tian Nannan Qian Peiyuan Chai Bing Liu Junjie Hu Craig Blackstone Desheng Zhu Junlin Teng Jianguo Chen | 2018 | Cell Research2018，28，8： | 9 |
| 4 | Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model显示文摘OBJECTIVE:To investigate the inhibitory effect of Yiguanjian decoction(YD) on DNA damage in Concanavalin A(Con A)-induced liver injury mice model and to explain the possible mechanism.METHODS:Totally 120 male BALB/c mice were randomly divided into 6 groups,20 mice each:normal group,model group,Bifendate group,YD low dose group,YD middle dose group and YD high dose group.Except normal group,liver injury model induced by Con A was established.While modeling,each mouse in YD group was given YD(0.4 m L/20 g per day) by intragastric administration(0.13 g YD for YD low dose group;0.26 g for YD middle dose group;0.52 g for YD high dose group).Bifendate group was given Bifendate(0.2 gnd model·kg-1 grou·d-1) by gavage.Normal group ap were fed with same volume of physiological saline daily.After 8 weeks,the serum alanine transaminase(ALT)and aspartate transaminase(AST) were tested.The hematoxylin-eosin staining was used to evaluate the grade of liver inflammation and liver fibrosis stage.Hepatocellular DNA damage was detected by single cell gel electrophoresis technology.The protein expression of tumor necrosis factor-α(TNF-α),Bax and Mut T Homolog 1(MTH1) was detected by western blotting and enzyme linked immunosorbent assay.Bax m RNA and MTH1 m RNA were detected by Real-time Polymerase Chain Reaction(PCR).RESULTS:YD can improve the degree of liver inflammation and fibrosis in the liver of chronic hepatitis mice,the dose effect relationship is remarkable(P < 0.05).YD can reduce liver cell DNA damage.The difference between YD middle dose group and model group was statistically significant(P < 0.05).YD middle dose group had decreased the protein expression of TNF-α in the mice liver of immunological liver injury(P < 0.05).YD can increase the protein expression of Bax(P < 0.05).Compared with normal group,the protein expression of MTH1 was decreased(P < 0.05),but there was no statistical significance between YD group and model group(P >0.05).YD can increase the m RNA expression of Bax and MTH1(both P < 0.05).CONCLUSION:YD can effectively inhibit the DNA damage in immunological liver injury mice,the mechanism may be that it can decrease the TNF-αand increase the Bax and MTH1 expression. | Tian Mengxi Liu Wenlan You Hongjie Zhao Qingzhou Ouyang Luodan Gao Biane Zhang Xin Che Niancong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 7 |
| 5 | LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication显示文摘Enhancer Ⅱ(ENII)is one of the critical cis-elements in the Hepatitis B Virus(HBV)genome for the hepatic viral gene transcription and DNA replication.The liver-specific activity of ENII is regulated by multiple liver-enriched transcription factors,including LRH-1/hB 1 F,HNF 1,HNF3β,HNF4 and C/EBP.Knowledge on the interplay of these important factors is still limited.In this study,we demonstrate a functional synergism between the orphan nuclear receptor LRH-1/hB 1F and the homeoprotein HNF1 in up-regulating the liver-specific activity of ENII.This synergism is sufficient for initiating the viral gene transcription and DNA replication in non-hepatic cells.We have defined the activation domains in hB 1F and HNF 1 that contribute to the synergism.We further show that hB 1F and HNF1 can interact directly in vitro and have mapped the domains required for this interaction. | YANNINGCAI QINGZHOU YUYINGKONG MEILI BENOITVIOLLET YOUHUAXIE YUANWANG | 2003 | Cell Research2003，13，6： | 6 |
| 6 | Stable isotopes of modern herbivore tooth enamel in the Tibetan Plateau: Implications for paleoelevation reconstructions显示文摘Fossil tooth enamel from herbivores is considered one of the best proxies for paleoclimate and paleoelevation reconstructions, due to its low susceptibility to diagenetic alteration. A synthesis of oxygen and carbon isotope analyses of modern tooth enamel from herbivores such as Tibetan yaks, asses and antelopes is assessed. The average δ 13C(PDB) value of herbivore tooth enamel in the Lhasa and south Qiangtang terrains is-11.3‰± 1.1‰, whereas in the north Qiangtang and Hoh Xil terrains value is-10.2‰± 1.4‰ consistent with the current C3-dominant ecotype in the Tibetan Plateau. In addition, the average δ18O(PDB) values from tooth enamel show a northward systematic increase from-11.8‰± 3.4‰ in the Gyirong Basin, to-11.1‰± 1.1‰ in the Lhasa and southern Qiangtang terrains, and then to-9.0‰± 1.1‰ in the northern Qiangtang and the Hoh Xil areas, similar to those of the local river water and precipitation variation trends. It is suggested that δ 18O(PDB) values of tooth enamel should not be used directly to evaluate the paleo-elevation of the Tibetan Plateau, because oxygen isotopic composition from tooth enamel is a com-bination of drinking water (precipitation-and river-sourced) and diet (plant-sourced). Moreover, an empirical relationship between oxygen isotope of tooth enamel and modern river water, and as well as elevation is recommended, which can be used in future studies of Tibetan Plateau paleoelevation. | XU Qiang DING Lin ZHANG LiYun YANG Di CAI FuLong LAI QingZhou LIU Jing SHI RenDeng | 2010 | Chinese Science Bulletin2010，55，1： | 4 |
| 7 | Distribution and expression of non-muscle myosin light chain kinase in rabbit livers显示文摘AIM: To study the distribution and expression of non-muscle myosin light chain kinase (nmMLCK) in rabbit livers.METHODS: Human nmMLCK N-terminal cDNA was amplified by polymerase chain reaction (PCR) and was inserted into pBKcmv to construct expression vectors. The recombinant plasmid was transformed into XL1-blue. Expression protein was induced by IPTG and then purified by SDS-PAGE and electroelution, which was used to prepare the polycolonal antibody to detect the distribution and expression of nmMLCK in rabbit livers with immunofluorescene techniques.RESULTS: The polyclonal antibody was prepared, by which nmMLCK expression was detected and distributed mainly in peripheral hepatocytes.CONCLUSION: nmMLCK can express in hepatocytes peripherally, and may play certain roles in the regulation of hepatic functions. | Hua-QingZhu YuanWang Ruo-LeiHu BinRen QingZhou Zhi-KuiJiang Shu-YuGui | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 8 | Data acquisition,analysis and applications of multi-sensor integration显示文摘This paper presents some key techniques for multi-sensor integration system, which is applied to the intelligent transportation system industry and surveying and mapping industry, e.g. road surface condition detection, digital map making. The techniques are synchronization control of multi-sensor, space-time benchmark for sensor data, and multi-sensor data fusion and mining. Firstly, synchronization control of multi-sensor is achieved through a synchronization control system which is composed of a time synchronization controller and some synchronization sub-controllers. The time synchronization controller can receive GPS time information from GPS satellites, relative distance information from distance measuring instrument and send space-time information to the synchronization sub-controller. The latter can work at three types of synchronization mode, i.e. active synchronization, passive synchronization and time service synchronization. Secondly, space-time benchmark can be established based on GPS time and global reference coordinate system, and can be obtained through position and azimuth determining system and synchronization control system. Thirdly, there are many types of data fusion and mining, e.g. GPS/Gyro/DMI data fusion, data fusion between stereophotogrammetry and PADS, data fusion between laser scanner and PADS, and data fusion between CCD camera and laser scanner. Finally, all these solutions presented in paper have been applied to two areas, i.e. land-borne intelligent road detection and measurement system and 3D measurement system based on unmanned helicopter. The former has equipped some highway engineering Co., Ltd. and has been successfully put into use. The latter is an ongoing research. | Li Qingquan Liu Yong Mao Qingzhou Yang Bisheng | 2010 | Engineering Sciences2010，8，1： | 3 |
| 9 | Loss of heterozygosity on chromosome 10q22-10q23 and 22q 11.2-22q 12.1 and p53gene in primary hepatocellular carcinoma显示文摘AIM: To analyze loss of heterozygosity (LOH) and homozygous deletion on p53 gene (exon2-3, 4 and 11), chromosome 10q22-10q23 and 22q11.2 -22q12.1 in human hepatocellular carcinoma (HCC).METHODS: PCR and PCR-based microsatellite polymorphism analysis techniques were used.RESULTS: LOH was observed at D10S579 (10q22-10q23) in 4 of 20 tumors (20%), at D22S421 (22q11.2-22q12.1) in 3 of 20(15%), at TP53.A (p53gene exon 2-3) in 4 of 20 (20%), at TP53.B (p53gene exon 4) in 6 of 20(30%), and at TP53.G (p53gene exon 11)in 0 of 20(0%). Homozygous deletion was detected at 10q22-10q23(8/20; 40%), 22q11.2-22q12.1(8/20; 40%), p53 gene exon 2-3(0/20;0%), p53gene exon 4(6/20; 30%), and p53gene exon 11(2/20; 10%).CONCLUSION: There might be unidentified tumor suppressor genes on chromosome 10q22-10q23 and 22q11.2-22q12.1 that contribute to the pathogenesis and development of HCC. | Guang-NengZhu LiZuo QingZhou Su-MeiZhang Hua-QingZhu Shu-YuGui YuanWang | 2004 | World Journal of Gastroenterology2004，10，13： | 3 |
| 10 | Single-step flash-heat synthesis of red phosphorus/ graphene flame-retardant composite as flexible anodes for sodium-ion batteries显示文摘红磷(RP ) 为高效的 Na 离子电池作为阳极吸引了可观的注意,由于它的低费用和 2,600 mAh/g 的高理论特定的能力。在这研究,一个灵巧的单个步的闪光热处理被开发完成 graphene 氧化物的减小(去) 并且 RP 的同时的免职到减少的 graphene 氧化物(rGO ) 上表。产生 RP/rGO 合成被显示是克服在骑车期间与差的电子传导性和 RP 的大体积变化联系的期的一个有希望的候选人。RP/rGO 灵活电影阳极在 1 A/g 的控告 / 解除电流密度在 200 个周期期间交付了 1,625 mAh/g 的一个平均能力。在 1, 2, 4,和 6 A/g 当前的密度的 1,786, 1,597, 1,324,和 679 mAh/g 的平均电荷能力在率能力测试被获得。而且由于 RP 部件, RP/rGO 电影与一部 rGO 电影相比介绍了优异火焰 retardancy。这个工作因此介绍一个高度可存取的合成方法向 Na 离子存储与优异电气化学的性能准备灵活、安全的 RP 阳极。 | Yihang Liu Anyi Zhang Chenfei Shen Qingzhou Liu Jiansong Cai Xuan Cao Chongwu Zhou | 2018 | Nano Research2018，11，7： | 3 |
| 11 | Identifying accident black spots based on the accident spacing distribution显示文摘The identification of accident black spots is of great significance for the prevention of traffic accidents.Commonly used accident black spot identification methods divide road sections for the analysis of accident data,the direct result of which is the splitting of accident black spots,which affects the results.This paper is based on three years of traffic accident data from the Beijing-Harbin Expressway,including the time and location of traffic accidents,form of the accident fatalities,severe injuries,slight injuries,and property damage only(PDO).To avoid road division effects,an identification method based on the accident spacing distribution is established by using quality control theory.The results show that the average number of accidents per kilometer by the method proposed in this paper is 42,which is much higher than 10,identified by other identification methods.The method proposed in this paper improves the accuracy of the identification results.This method avoids the problem of road segmentation found in other common methods and can more accurately reflect the spatial distribution of traffic accidents.Thus making the identification of accidents more scientific and accurate. | Hongjun Cui Jianguo Dong Minqing Zhu Xia Li Qingzhou Wang | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 2 |
| 12 | Quasi-two-dimensionalβ-Ga2O3 field effect transistors with large drain current density and low contact resistance via controlled formation of interfacial oxygen vacancies显示文摘Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of 4.6-4.9eV.It has been reported to be a promising material for next-generation power and radio frequency electronics.Field effect transistors(FETs)that can switch at high voltage are key compone nts in power and radio frequency devices,and reliable Ohmic con tacts are essential for high FET performance.However,obtaining low contact resistance onβ-Ga2O3 FETs is difficult since reactions betweenβ-Ga2O3 and metal contacts are not fully understood.Herein,we experimentally demonstrate the importanee of reactions at the metal/β-Ga2O3 interface and the corresponding effects of these reactions on FET performance.When Ti is employed as the metal contact,annealing ofβ-Ga2O3 FETs in argon can effectively transform Schottky contacts into Ohmic contacts and permit a large drain current density of-3.1 mA//μm.The contact resistance(Rcontact)between the Ti electrodes andβ-Ga2O3 decreased from^430 to^0.387Ω·mm after annealing.X-ray photoelectron spectroscopy(XPS)confirmed the formation of oxygen vacancies at the Ti/β-Ga2O3 interface after annealing,which is believed to cause the improved FET performance.The results of this study pave the way for greater application ofβ-Ga2O3 in electronics. | Zhen Li Yihang Liu Anyi Zhang Qingzhou Liu Chenfei Shen Fanqi Wu Chi Xu Mingrui Chen Hongyu Fu Chongwu Zhou | 2019 | Nano Research2019，12，1： | 2 |
| 13 | Sensitivity optimization of a monolithic high-shock three-axis piezoresistive accelerometer with single sensing element显示文摘There exist several difficulties in the design of monolithic high-shock three-axis accelerometer, such as high g overload, transverse overload and the cross coupling in three dimensions, etc. It is necessary to optimize the sensitivity to improve the performance of the accelerometer. For the monolithic high-shock three-axis accelerometer, the complexity of the sensitivity optimization is that it should consider not only the sensitivity difference between different axes but also the elimination of cross-coupling outputs, together with the natural frequency, structural integrity and high g overload. In this paper, the optimization process for decreasing the difference of the sensitivities between different axes of a monolithic high-shock three-axis piezoresistive accelerometer with single sensing element is established. The optimization is conducted in the condition of 100000 g acceleration by two methods-the method based on the optimization module of ANSYS and the ACO (ant colony optimization) method. The comparison between un-optimized and optimized models proves the efficiency of the optimization methods. In addition, the optimization results show that the ACO method combined with the FEA (finite element analysis) is much more efficient than the method based on the optimization module of ANSYS for the structural optimization problem. And the ACO method can be widely used in the optimization problem of the sensing elements with complicated structure. | SONG Ping LI QingZhou LI KeJie | 2009 | Chinese Science Bulletin2009，54，19： | 2 |
| 14 | Development of a Soil Stabilizer for Road Subgrade Based on Original Phosphogypsum显示文摘The research used industrial by-products original phosphogypsum(PG)as the main raw material,slag(SG)and Portland cement(PC)as auxiliary materials,and the optimal additive amount was determined according to the compressive strength value of the sample.Comprehensively evaluate the water resistance and volume stability of the samples,and determine the best formula for new roadbed stabilized materials.The results showed that when the weight ratio of PG,slag and cement was OPG:SG:PC=6:3:1,and mixed with 5%micro silica fume(MSF)and 3‰hydroxypropyl methyl cellulose(HPMC),the sample’s comprehensive performance was the best,specifically,the sample’s compressive strength in 60 days reached 28.8 MPa,the softening coefficient reached 0.9,and the expansion rate was stable at about−0.2%.In addition,the mechanism of action of enhancers MSF and HPMC was analyzed according to use Vicat device,X-ray diffractometer and scanning electron microscope.The best formula SP3GH3 has the best curing effect on soil.The 28-day unconfined compressive strength(UCS)of the sample reached 2.4 MPa,the expansion rate was less than 0.09%,and the water stability coefficient was above 0.79,which was higher than that of the samples cured by traditional cement and lime during the same period. | Zenghuan Gu Aiguo Fang Sudong Hua Qingzhou Zhao Lidong Sun Fan Xia Liying Qian Xiaojian Ren | 2021 | Journal of Renewable Materials2021，9，2： | 2 |
| 15 | Simultaneous Determination of Lanthanum and Cerium in Mixed Rare Earths显示文摘 | Zhai Qingzhou | 1998 | Talanta1998，415，5： | 2 |
| 16 | Desicca- tion and cold storage of Galleria mellonella cadavers and effects on in vivo production of Steinernema carpocapsae 显示文摘 | Wang Xin Wang Huan Feng Qingzhou | 2014 | Pest Management Science2014，70，6： | 1 |
| 17 | Paleogene high elevations in the Qiangtang Terrane, central Tibetan Plateau显示文摘 | Qiang Xu Lin Ding Liyun Zhang Fulong Cai Qingzhou Lai Di Yang Jing Liu-Zeng | 2013 | Earth and Planetary Science Letters2013，，： | 1 |
| 18 | Study on Urban Construction History and Culture of the Tortoise City of Ganzhou | WU Qingzhou School of Architecture & State Key Laboratory of Subtropical Building Science Research Center of Architecture History and Culture, South China University of Technology | 2011 | China City Planning Review2011，20，4： | 1 |
| 19 | Independent component analysis of Alzheimer's DNA microarray gene expression data 显示文摘 | Wei K Xiaoyang M Qingzhou L etal | 2009 | Molecular Neurodegenera- tion2009，4，5： | 1 |
| 20 | Rapid degradation of azo dye methyl orange using hollow cobalt nanoparticles 显示文摘 | Yingying Sha Iswarya Mathewa Qingzhou Cui | 2016 | Chemosphere2016，144，： | 1 |
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