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| 1 | Current application of proteomics in biomarker discoveryfor inflammatory bowel disease显示文摘Recently, the field of proteomics has rapidly expanded in its application towards clinical research with objectives ranging from elucidating disease pathogenesis to discovering clinical biomarkers. As proteins govern and/or reflect underlying cellular processes, the study of proteomics provides an attractive avenue for research as it allows for the rapid identification of protein profiles in a biological sample. Inflammatory bowel disease(IBD) encompasses several heterogeneous and chronic conditions of the gastrointestinal tract. Proteomic technology provides a powerful means of addressing major challenges in IBD today, especially for identifying biomarkers to improve its diagnosis and management. This review will examine the current state of IBD proteomics research and its use in biomarker research. Furthermore, we also discuss the challenges of translating proteomic research into clinically relevant tools. The potential application of this growing field is enormous and is likely to provide significant insights towards improving our future understanding and management of IBD. | Patrick PY Chan Valerie C Wasinger Rupert W Leong | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 2 | Regulation of 11beta-hydroxysteroid dehydrogenase type 1 gene expression in human ovarian surface epithelial cells by interleukin-1显示文摘 | Yong PY Harlow C Hillier SG, | 2002 | Hum Reprod2002，17，： | 1 |
| 3 | Effect of prostaglandin F2 alpha on aqueous humor dynamics of rabbit,cat and monkey显示文摘 | Lee PY Pods SM Severin C | 1984 | Invest Ophthalmol Vis Sci1984，25，： | 1 |
| 4 | Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking 显示文摘 | Patient R Hourioux C Sizaret PY | 2007 | J Virol2007，81，8： | 1 |
| 5 | Assessment and comparison of intraoperative and postoperative pain associated with NovaSure and Therma choice endometrial ablation systems 显示文摘 | Laberge PY Sabbah R Fortin C | 2003 | J Am Assoc Gynecol Laparosc2003，10，2： | 1 |
| 6 | Phase Ⅱ study of sorafenib in combination with cisplatin and 5-fluorouracil to treat recurrent or metastatic nasopharyngeal carcinoma显示文摘 | Xue C Huang Y Huang PY | 2013 | Ann Oncol2013，24，4： | 1 |
| 7 | Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking显示文摘 | Patient R Hourioux C Sizaret PY | 2007 | J Virol2007，81，8： | 1 |
| 8 | Hepatie resection for bilateral hep- atolithiasis: a 20-year experience 显示文摘 | Lin CC Lin PY Ko C J | 2013 | ANZ J Surg2013，83，12： | 1 |
| 9 | A novel pathway for mammary epithelial cell invasion induced by the helix - loop - helix protein显示文摘 | Desprez PY Lin C Q Thomasset N | 1998 | Cell Biol1998，18，： | 1 |
| 10 | Comparative analysis of human DNA variations by fluorescence 2 based sequencing of PCR products 显示文摘 | Kwok PY Carlson C Yager TD | 1994 | Genomics1994，23，1： | 1 |
| 11 | Genetic analysis of enterovirus 71 iso- lated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998 显示文摘 | Shih SR Ho MS Lin KH Wu SL Chen YT Wu CN Lin TY Chang LY Tsao KC Ning HC Chang PY Jung SM Hsueh C Chang KS | 2000 | Virus Res2000，68，2： | 1 |
| 12 | Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation显示文摘 | Wai PY Guo L Gao C | | 0，，02： | 1 |
| 13 | Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine显示文摘 | Zheng PY Feng BS Oluwole C | | 0，，11： | 1 |
| 14 | Very high frepuency(13 MHz) ultrasonogrphic examination of the normal neck:detection of normal lymph nodes and thyroid nodules显示文摘 | Bruneton JN Balu-Maestro C Marcy PY | | 0，，02： | 1 |
| 15 | Successful treatment of a life-threatening air leakage,complicating severe abdominalsepsis,with a one-way endobronchial valve显示文摘 | Brichon PY Poquet C Arvieux C | 2012 | Interact Cardiovasc Thorac Surg2012，15，4： | 1 |
| 16 | IL -4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B显示文摘 | Lin SJ Shu PY Chang C | 2003 | J Immunol2003，171，9： | 1 |
| 17 | Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiency显示文摘 | Meier C Liu PY Ly LP | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
| 18 | Risk factors ofinfluenza transmission in households 显示文摘 | Viboud C Boelle PY Cauchemez S | 2004 | Br J Gen Pract2004，54，506： | 1 |
| 19 | Endogenous antimicrobial peptides and skin infections in atopic dermatitis显示文摘 | Ong PY Ohtake T Brandt C Strickland I | 2002 | N Engl J Med2002，347，15： | 1 |
| 20 | Cyclosporine A eyedrops:manufacturing toxicity, pharmacokinetics in 2000显示文摘 | Robert PY Leconte V Olive C | 2001 | J Fr Ophthalmol2001，24，5： | 1 |
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