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| 1 | Gastric cancer:Prevention,screening and early diagnosis显示文摘Gastric cancer continues to be an important healthcare problem from a global perspective. Most of the cases in the Western world are diagnosed at late stages when the treatment is largely ineffective. Helicobacter pylori(H. pylori) infection is a well-established carcinogen for gastric cancer. While lifestyle factors are important,the efficacy of interventions in their modification,as in the use of antioxidant supplements,is unconvincing. No organized screening programs can be found outside Asia(Japan and South Korea). Although several screening approaches have been proposed,including indirect atrophy detection by measuring pepsinogen in the circulation,none of them have so far been implemented,and more study data is required to justify any implementation. Mass eradication of H. pylori in high-risk areas tends to be cost-effective,but its adverse effects and resistance remain a concern. Searches for new screening biomarkers,including microRNA and cancer-autoantibody panels,as well as detection of volatile organic compounds in the breath,are in progress. Endoscopy with a proper biopsy follow-up remains the standard for early detection of cancer and related premalignant lesions. At the same time,new advanced high-resolution endoscopic technologies are showing promising results with respect to diagnosing mucosal lesions visually and targeting each biopsy. New histological risk stratifications(classifications),including OLGA and OLGIM,have recently been developed. This review addresses the current means for gastric cancer primary and secondary prevention,the available and emerging methods for screening,and new developments in endoscopic detection of early lesions of the stomach. | Victor Pasechnikov Sergej Chukov Evgeny Fedorov Ilze Kikuste Marcis Leja | 2014 | World Journal of Gastroenterology2014，20，38： | 64 |
| 2 | Cloning of differentially expressed genes in human hepatocellular carcinoma and nontumor liver显示文摘INTRODUCTIONThe mechanism of hepatocellular carcinoma(HCC)is still unclear,although some genes have been found to play a role in the transformation of liver cells,and a variety of studies have described differences in gene expression which distinguished tumor from nontumor[1-6].The new genes,especially the functional genes directly related with tumor are still worth being found.The purpose of our study is to find the different genes between human liver tumor and normal tissues using suppression subtractive hybridization. | Xiao-Yan Cao Jie Liu Zhao-Rui Lian Marcy Clayton Jia-Lu Hu Ming-Hua Zh Dai-Ming Fan Mark Feitelson Institute of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Pathology & Cell Biology,Thomas Jefferson University,Philadelphia,PA19107 USADepartment of Pathology,Second Military Medical University,Shanghai 200433,China | 2001 | World Journal of Gastroenterology2001，7，4： | 7 |
| 3 | Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce inflammation following traumatic brain injury显示文摘The pathologic process of chronic phase traumatic brain injury is associated with spreading inflammation,cell death,and neural dysfunction.It is thought that sequestration of inflammatory mediators can facilitate recovery and promote an environment that fosters cellular regeneration.Studies have targeted post-traumatic brain injury inflammation with the use of pharmacotherapy and cell therapy.These therapeutic options are aimed at reducing the edematous and neurodegenerative inflammation that have been associated with compromising the integrity of the blood-brain barrier.Although studies have yielded positive results from anti-inflammatory pharmacotherapy and cell therapy individually,emerging research has begun to target inflammation using combination therapy.The joint use of anti-inflammatory drugs alongside stem cell transplantation may provide better clinical outcomes for traumatic brain injury patients.Despite the promising results in this field of research,it is important to note that most of the studies mentioned in this review have completed their studies using animal models.Translation of this research into a clinical setting will require additional laboratory experiments and larger preclinical trials. | Sherwin Mashkouri Marci G.Crowley Michael G.Liska Sydney Corey Cesar V.Borlongan | 2016 | Neural Regeneration Research2016，11，9： | 5 |
| 4 | 人是如何学习的——兼谈技术在学习中的作用显示文摘在去年春天的教育大会中,我参加了一次有关教学技术在转变学校的教与学中的潜力的讨论.其中有一个发言人讲述了发生在他14岁儿子身上的故事.儿子跟他一样,对教育技术的新鲜玩艺非常钟情,并总是希望拥有即将在市面上流行的最新和最先进的技术产品.有一天,儿子将一个电视机遥控程序下载到自己的掌中宝(掌上电脑)后,就去上学了.那天上课时,他用下载的软件将教室角落里的电视机不停地开机、关机. | Marcy P.Driscoll 胡平洲 | 2003 | 远程教育杂志2003，21，5： | 4 |
| 5 | Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury显示文摘Neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability – thus, the search for novel therapeutic approaches for these disorders continues. Many hurdles have hindered the translation of effective therapies for traumatic brain injury and stroke primarily because of the inherent complexity of neuropathologies and an inability of current treatment approaches to adapt to the unique cell death pathways that accompany the disorder symptoms. Indeed, developing potent treatments for brain injury that incorporate dynamic and multiple disorder-engaging therapeutic targets are likely to produce more effective outcomes than traditional drugs. The therapeutic use of hypothermia presents a promising option which may fit these criteria. While regulated temperature reduction has displayed great promise in preclinical studies of brain injury, clinical trials have been far less consistent and associated with adverse effects, especially when hypothermia is pursued via systemic cooling. Accordingly, devising better methods of inducing hypothermia may facilitate the entry of this treatment modality into the clinic. The use of the delta opioid peptide D-alanine D-leucine enkephalin(DADLE) to pharmacologically induce temperature reduction may offer a potent alternative, as DADLE displays both the ability to cause temperature reduction and to confer a broad profile of other neuroprotective and neuroregenerative processes. This review explores the prospect of DADLE-mediated hypothermia to treat neurovascular brain injuries, emphasizing the translational steps necessary for its clinical translation. | M.Grant Liska Marci G.Crowley Julian P.Tuazon Cesar V.Borlongan | 2018 | Neural Regeneration Research2018，13，12： | 4 |
| 6 | Focus on intracytoplasmic morphologically selected sperm injection (IMSI). a mini-review显示文摘Intracytoplasmic 精子注射(ICSI ) 是在坏分子不孕的许多情况中的推荐治疗。几研究表明了在最佳的精子形态学和积极 ICSI 结果之间的积极关联。事实上,有头的严重畸形的精子很好被记录与低使肥沃,培植和怀孕率被联系。然而,作为 ‘ 被分类的一个精子;由在低放大的显微镜的观察的 normal' 能包含损害使肥沃过程和胚胎的开发的 ultrastructural 缺点。intracytoplasmic 词法上选择了注射(IMSI ) 过程改变了的精子对注射合适的一个精子应该显得怎么样的感觉。精子选择在 × 被执行; 6000 放大,允许改进了对精子原子核的评价。当前,标准化了临床的指示因为 IMSI 正在缺乏,候选人在他们的病历或精子暂停的小心的分析的根据上被选择。进一步未来的使随机化的研究被需要在病人的特定的组证实 IMSI 的优点。除了提供 IMSI 过程的简短概述,这研究试图考察文学,它解释理论基础和这种技术的临床的结果。IMSI 与改进培植和临床的怀孕被联系的几报告表演象更低的流产率一样评价什么时候与 ICSI 相比。尽管在精子的反常原子核形状,增加的 DNA 破碎和否定实验室和临床的结果之间的可能的关联长被调查了,结果正在冲突。 | Giuseppe Lo Monte Fabien Murisier Isabella Piva Marc Germond Roberto Marci | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 7 | Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global Perspective显示文摘 | Marcie Tomblyn Tom Chiller Hermann Einsele Ronald Gress Kent Sepkowitz Jan Storek John R. Wingard Jo-Anne H. Young Michael A. Boeckh | 2009 | Biology of Blood and Marrow Transplantation2009，，10： | 3 |
| 8 | 精氨酸酶I在HCV转染肝癌细胞增殖中的作用显示文摘目的:研究丙型肝炎病毒(hepatitis C virus,HCV)基因组转染的肝癌细胞中精氨酸酶Ⅰ的表达及其意义,探究其在HCV-肝细胞肝癌(HCC)发病中的作用。方法:以转染HCV基因组的人肝癌细胞系(Huh7)为研究对象,采用蛋白印迹技术研究HCV基因组转染对细胞内精氨酸酶Ⅰ表达的影响;运用小干扰RNA(siRNA)技术抑制细胞精氨酸酶Ⅰ表达,并探讨其对细胞生长的影响及作用机制。结果:精氨酸酶Ⅰ在HCV阳性肝癌细胞系(Huh7-HCV)中的表达上调,且与对照细胞相比,Huh7-HCV细胞的精氨酸酶Ⅰ含量升高4.3倍。运用siRNA抑制细胞精氨酸酶Ⅰ表达,可明显抑制细胞生长并导致其死亡,且可使细胞周期发生明显改变。结论:精氨酸酶Ⅰ在HCV阳性肝细胞Huh7中表达上调,可能对促进Huh7-HCV细胞生长具重要意义。 | 曹文俊 Bill Sun 连兆瑞 Marcy Clayton Mark Feitelson 樊绮诗 | 2007 | 诊断学理论与实践2007，6，4： | 3 |
| 9 | Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization显示文摘 | Takayuki Asahara Haruchika Masuda Tomono Takahashi Christoph Kalka Christopher Pastore Marcy Silver Marianne Kearne Meredith Magner Jeffrey M. Isner | 1999 | Circulation Research1999，，3： | 3 |
| 10 | Wrist Fractures显示文摘 | Douglas P Hanel Marci D Jones Thomas E Trumble | 2002 | Orthopedic Clinics of North America2002，，1： | 3 |
| 11 | 感染土拨鼠乙肝病毒的小鼠非瘤组织与肝细胞癌的差异表达基因显示文摘目的 确定土拨鼠HBV引发的肝癌组织和非癌组织中差异表达的基因。方法 通过抑制消减杂交法克隆土拨鼠HBV引发的肝癌组织和非癌组织中差异表达的基因 ;对差异表达基因进行DNA序列测定后于GeneBank内分析其同源性 ;应用原位杂交确定差异基因在肝癌组织和非癌组织中的特异性表达。结果 通过抑制消减杂交共得到了 14条肿瘤组织差异表达的基因片段。其中 ,肿瘤组织和非瘤组织共有的 8条基因与GeneBank中的已知基因同源 ,肿瘤组织来源的 5条基因和非瘤组织来源的 1条基因在GeneBank中未找到同源基因。原位杂交差异基因在肝癌组织和非癌组织中均为特异性表达。结论 通过抑制消减杂交获得了 14条肝癌组织和非癌组织差异表达的基因 。 | 曹晓燕 刘杰 连兆瑞 Marcy Clayton 胡加露 朱明华 樊代明 Mark Feitelson | 2001 | 陕西肿瘤医学2001，9，2： | 2 |
| 12 | Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization显示文摘 | Takayuki Asahara Haruchika Masuda Tomono Takahashi Christoph Kalka Christopher Pastore Marcy Silver Marianne Kearne Meredith Magner Jeffrey M. Isner | 1999 | Circulation Research1999，，3： | 2 |
| 13 | Stoichiometry of soil enzyme activity at global scale显示文摘 | Robert L.Sinsabaugh Christian L.Lauber Michael N.Weintraub BonyAhmed Steven D.Allison ChelseaCrenshaw Alexandra R.Contosta DanielaCusack SeritaFrey Marcy E.Gallo Tracy B.Gartner Sarah E.Hobbie KeriHolland Bonnie L.Keeler Jennifer S.Powers MartinaStursova | 2008 | Ecology Letters2008，，11： | 2 |
| 14 | Relationship Formation on the Internet: What’s the Big Attraction?显示文摘 | Katelyn Y. A.McKenna Amie S.Green Marci E. J.Gleason | 2002 | Journal of Social Issues2002，，1： | 2 |
| 15 | Atrophic gastritis and gastric cancer tissue miRNome analysis reveals hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers显示文摘BACKGROUND Gastric cancer(GC)is one of the most frequently diagnosed tumor globally.In most cases,GC develops in a stepwise manner from chronic gastritis or atrophic gastritis(AG)to cancer.One of the major issues in clinical settings of GC is diagnosis at advanced disease stages resulting in poor prognosis.Micro RNAs(mi RNAs)are small noncoding molecules that play an essential role in a variety of fundamental biological processes.However,clinical potential of mi RNA profiling in the gastric cancerogenesis,especially in premalignant GC cases,remains unclear.AIM To evaluate the AG and GC tissue mi RNomes and identify specific mi RNAs’potential for clinical applications(e.g.,non-invasive diagnostics).METHODS Study included a total of 125 subjects:Controls(CON),AG,and GC patients.All study subjects were recruited at the Departments of Surgery or Gastroenterology,Hospital of Lithuanian University of Health Sciences and divided into the profiling(n=60)and validation(n=65)cohorts.Total RNA isolated from tissue samples was used for preparation of small RNA sequencing libraries and profiled using next-generation sequencing(NGS).Based on NGS data,deregulated mi RNAs hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p were analyzed in plasma samples of independent cohort consisting of CON,AG,and GC patients.Expression level of hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p was determined using the quantitative real-time polymerase chain reaction and 2-ΔΔCt method.RESULTS Results of tissue analysis revealed 20 differentially expressed mi RNAs in AG group compared to CON group,129 deregulated mi RNAs in GC compared to CON,and 99 altered mi RNAs comparing GC and AG groups.Only 2 mi RNAs(hsa-mi R-129-1-3 p and hsa-mi R-196 a-5 p)were identified to be step-wise deregulated in healthy-premalignant-malignant sequence.Area under the curve(AUC)-receiver operating characteristic analysis revealed that expression level of hsa-mi R-196 a-5 p is significant for discrimination of CON vs AG,CON vs GC and AG vs GC and resulted in AUCs:88.0%,93.1%and 66.3%,respectively.Comparing results in tissue and plasma samples,hsa-mi R-129-1-3 p was significantly down-regulated in GC compared to AG(P=0.0021 and P=0.024,tissue and plasma,respectively).Moreover,analysis revealed that hsa-mi R-215-3 p/5 p and hsa-mi R-934 were significantly deregulated in GC based on Helicobacter pylori(H.pylori)infection status[log2 fold change(FC)=-4.52,P-adjusted=0.02;log2 FC=-4.00,P-adjusted=0.02;log2 FC=6.09,P-adjusted=0.02,respectively].CONCLUSION Comprehensive mi RNome study provides evidence for gradual deregulation of hsa-mi R-196 a-5 p and hsa-mi R-129-1-3 p in gastric carcinogenesis and found hsami R-215-3 p/5 p and hsa-mi R-934 to be significantly deregulated in H.pylori carrying GC patients. | Greta Varkalaite Evelina Vaitkeviciute Ruta Inciuraite Violeta Salteniene Simonas Juzenas Vytenis Petkevicius Rita Gudaityte Antanas Mickevicius Alexander Link Limas Kupcinskas Marcis Leja Juozas Kupcinskas Jurgita Skieceviciene | 2022 | World Journal of Gastroenterology2022，28，6： | 2 |
| 16 | Polymorphisms of micro RNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer显示文摘AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC. | Vytenis Petkevicius Violeta Salteniene Simonas Juzenas Thomas Wex Alexander Link Marcis Leja Ruta Steponaitiene Jurgita Skieceviciene Limas Kupcinskas Laimas Jonaitis Gediminas Kiudelis Peter Malfertheiner Juozas Kupcinskas | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 17 | Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a no- vel inhibitor of the JNK signaling pathway显示文摘 | Anna C Maroney Marcie A Clicksman | 1998 | The Journal of Neuroscience1998，18，1： | 1 |
| 18 | Aortic embolism of cement:a rare complication of lumbar percutaneous vertebroplasty显示文摘 | Amoretti N Hovorka I Marcy PY | | 0，，07： | 1 |
| 19 | Depression in primary caregivers of patients listed for liver or kidney transplantation显示文摘 | Ahmed B Marci ML Donna ME | 2007 | Progress in Transplantation2007，17，3： | 1 |
| 20 | Effect of carbon-fiber-reinforced polymer laminate configuration on the behavior of strengthened reinforced concrete beams显示文摘 | Brena S F Marci B M | 2004 | Journal of Composites for Construction A S CE2004，8，3： | 1 |
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