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| 1 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 2 | Flow cytometry for high-throughput, high-content screening显示文摘 | EDWARDS BS OPREA T PROSSNITZ ER | 2004 | Curr Opin Chem Biol2004，8，4： | 1 |
| 3 | Obesity, insulin resistance and diabetes: Sex differences and role of oestrogen receptors 显示文摘 | Meyer M R Clegg D J Prossnitz E R | 2011 | Acta Physiol (Oxf)2011，203，1： | 1 |
| 4 | Non-genomic regulation of vascular cell function and growth by estrogen显示文摘 | Meyer MR Haas E Prossnitz ER | 2009 | Mol Cell Endocrinol2009，308，： | 1 |
| 5 | GPR30:A G protein-coupled receptor for estrogen显示文摘 | Prossnitz ER Arterburn JB Sklar LA | | 0，，： | 1 |
| 6 | Estrogen signaling through the transmembrane G protein-Coupled receptor GPR30 显示文摘 | Prossnitz ER Arterburn JB Smith HO | 2008 | Annu Rev Physiol2008，70，： | 1 |
| 7 | GPR30:A G protein-coupled receptor for estrogen 显示文摘 | Prossnitz ER Arterburn JB Sklar LA | 2007 | Mol Cell Endocrinol2007，，： | 1 |
| 8 | Expression of G proteincoupled receptor 30 in the hamster ovary : differential regulation by gonadotropins and steroid hormones 显示文摘 | Wang C Prossnitz ER Roy SK | 2007 | Endocrinology2007，148，： | 1 |
| 9 | The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function显示文摘 | Prossnitz ER Ye RD | 1997 | Pharmacol Ther1997，74，： | 1 |
| 10 | Expression of G protein- coupled receptor 30 in the hamster ovary: differential regula- tion by gonadotropins and steroid hormones显示文摘 | Wang C Prossnitz E R Roy S K | 2007 | Endocrinolo- gy2007，148，10： | 1 |
| 11 | Multiple activation steps of the N-formyl peptide receptor显示文摘 | Prossnitz E R Gilbert T L Chiang S | 1999 | Bioch mistry1999，38，： | 1 |
| 12 | Estrogen biology:new insights into GPER function and clinical opportunities显示文摘 | PROSSNITZ E R BARTON M | 2014 | Molecular and Cellular Endocrinology2014，389，12： | 1 |
| 13 | Estrogen biology:new insights into GPER function and clinical opportunities显示文摘 | Prossnitz ER Barton M | 2014 | Mol Cell Endocrinol2014，389，12： | 1 |
| 14 | GPER mediates estrogeninduced signaling and proliferation in human breast epithelial cells and normal and malignant breast显示文摘 | Scaling AL Prossnitz ER Hathaway HJ | 2014 | Horm Cancer2014，5，3： | 1 |
| 15 | Estrogen Signaling through the Transmembrane G Protein-Coupled Receptor GPR30显示文摘 | Prossnitz ER Arterburn JB Smith HO | 2008 | Annu Rev Physiol2008，70，： | 1 |
| 16 | Mechanisms of estrogen signaling and gene expression via GPR30显示文摘 | Prossnitz ER Maggiolini M | | 0，，： | 1 |
| 17 | The G protein-coupled receptor GPER/GPR30 as a regulator of cardiovascular function显示文摘 | Meyer M Prossnitz E Barto M | | 0，，： | 1 |
| 18 | Obesity,insulin resistance and diabetes:sex differences and role of oestrogen receptors显示文摘 | Meyer MR Clegg DJ Prossnitz ER | 2011 | Acta Physiologica2011，203，1： | 1 |
| 19 | GPER Mediates Estrogen-Induced Signaling and Proliferation in Human Breast Epithelial Cells and Normal and Malignant Breast显示文摘 | Allison L. Scaling Eric R. Prossnitz Helen J. Hathaway | 2014 | Hormones and Cancer2014，，： | 1 |
| 20 | Non-genomic regulation of vascular cell function and growth by estrogen显示文摘 | Meyer M R Haas E Prossnitz E R | 2009 | Molecularand Cellular Endocrinology2009，308，12： | 1 |
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