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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 3 | The folkestone bed sands:microfabric and strength显示文摘 | Richards N P Barton M E | 1999 | Study Journal of Engineering Geology1999，32，： | 2 |
| 4 | Endothelin and cardiac arrhythmias:Do endothelinantagonists have a therapeutic potential as antiarrhythmic drugs?显示文摘 | Duru F Barton M Luscher TF | 2001 | Cardiovasc Res2001，49，： | 1 |
| 5 | Pseudorapidity and centrality dependence of the collective flow of charged particles in Au + Au colli- sions at √SNN = 130 GeV显示文摘 | Back B B Baker M D Barton D S | 2002 | Phys Rev Lett2002，89，22： | 1 |
| 6 | Azithromycin as the first-line treatment of non-gonococcal urethritis (NGU): a study of follow-up rates, contact attendance and patients' treatment preference显示文摘 | Carlin E M Barton S E | 1996 | Int J STD AIDS1996，7，3： | 1 |
| 7 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine显示文摘 | O'NEIL M M KENNEDY C A BARTON R W | 2001 | Gene Therapy2001，，8： | 1 |
| 8 | Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer显示文摘 | H BARTON GROSSMAN RONALD B NATALE CATHERINE M | 2003 | N Engl J Med2003，349，： | 1 |
| 9 | Effects of Soil Conservation Measures on Erosion Rates and Crop Productivity on Subtropical Ultisols in Yunnan Province,China显示文摘 | BARTON A P FULLEN M A MITCHELL D J | 2004 | Agriculture Ecosystems and Environment2004，104，2： | 1 |
| 10 | Systemic administration of Larginine benefits mdx skeletal muscle function显示文摘 | Barton ER Morris L Kawana M | 2005 | Muscle Nerve2005，32，6： | 1 |
| 11 | A comparison of three indirect method for estimateing average levels of gene flow 显示文摘 | SLATKIN M BARTON N H | 1989 | Evolution1989，43，： | 1 |
| 12 | The effect of wating for radiotherapy for grade/ N gliomss显示文摘 | Do V Gebski V Barton M | 2000 | Radiother Oncol2000，57，2： | 1 |
| 13 | Monitoring floods with AVHRR 显示文摘 | Barton I J Bathols J M | 1989 | Remote Sensing of Environment (S0034-4257)1989，30，1： | 1 |
| 14 | Pattern and consequences of interspecific competition in natural communities:a review of field experiments with plants显示文摘 | Goldberg D E Barton A M | 1992 | American Naturalist1992，139，： | 1 |
| 15 | Crural repair permits morbidly obese patients with not large hiatal hernia to choose laparoscopic adjustable banding as a bariatric surgical treatment显示文摘 | Frezza E E Barton A Wachtel M S | 2008 | Obes Surg2008，18，5： | 1 |
| 16 | Transmission line resistance compression networks and applications to wireless power transfer显示文摘 | BARTON T W GORDONSON J M PERREAULT D J | 2015 | IEEE Journal of Emerging and Selected Topics in Power Electronics2015，3，1： | 1 |
| 17 | Expectant management of severe preeclampsia at 27 (0/7) to 33 ( 6/7 ) weeks gestation : maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management 显示文摘 | BOMBRYS A E BARTON J R HABLI M | 2009 | American Journal of Perinatology2009，26，6： | 1 |
| 18 | Evidence that monoclonal antibodies directed against the integrin β subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension显示文摘 | Mould A P Travis M A Barton S J | 2005 | J Biol Chem2005，280，6： | 1 |
| 19 | Risk factors and outcomes a-mong children admitted to hospital with pandemic H1N1 influenza显示文摘 | O'Riordan S Barton M Yau Y | 2010 | CMAJ2010，182，1： | 1 |
| 20 | Expectant management of severe preeclampsia at 27(0/7) to 33(6/7) weeks' gestation:maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management显示文摘 | Bombrys A E Barton J R Habli M | 2009 | Am J Perinatol2009，26，6： | 1 |
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