| 2 | Critical evaluation of contemporary management in a new Pelvic Exenteration Unit: The first 25 consecutive cases显示文摘AIM To critically appraise short-term outcomes in patientstreated in a new Pelvic Exenteration(PE) Unit.METHODS This retrospective observational study was conducted by analysing prospectively collected data for the first 25 patients(16 males, 9 females) who underwent PE for advanced pelvic tumours in our PE Unit between January 2012 and October 2016. Data evaluated included age, co-morbidities, American Society of Anesthesiologists(ASA) score, Eastern Cooperative Oncology Group(ECOG) status, preoperative adjuvant treatment, intra-operative blood loss, procedural duration, perioperative adverse event, lengths of intensive care unit(ICU) stay and hospital stay, and oncological outcome. Quantitative data were summarized as percentage or median and range, and statistically assessed by the χ~2 test or Fisher's exact test, as applicable.RESULTS All 25 patients received comprehensive preoperative assessment via our dedicated multidisciplinary team approach. Long-course neoadjuvant chemoradiotherapy was provided, if indicated. The median age of the patients was 61.9-year-old. The median ASA and ECOG scores were 2 and 0, respectively. The indications for PE were local y invasive rectal adenocarcinoma(n = 13), advanced colonic adenocarcinoma(n = 5), recurrent cervical carcinoma(n = 3) and malignant sacral chordoma(n = 3). The procedures comprised 10 total PEs, 4 anterior PEs, 7 posterior PEs and 4 isolated lateral PEs. The median follow-up period was 17.6 mo. The median operative time was 11.5 h. The median volume of blood loss was 3306 mL, and the median volume of red cell transfusion was 1475 mL. The median lengths of ICU stay and of hospital stay were 1 d and 21 d, respectively. There was no case of mortality related to surgery. There were a total of 20 surgical morbidities, which occurred in 12 patients. The majority of the complications were grade 2 Clavien-Dindo. Only 2 patients experienced grade 3 Clavien-Dindo complications, and both required procedural interventions. One patient experienced grade 4a Clavien-Dindo complication, requiring temporary renal dialysis without long-term disability. The R0 resection rate was 64%. There were 7 post-exenteration recurrences during the follow-up period. No statistically significant relationship was found among histological origin of tumour, microscopic resection margin status and postoperative recurrence(P = 0.67). Four patients died from sequelae of recurrent disease during follow-up.CONCLUSION By utilizing modern assessment and surgical techniques, our PE Unit can manage complex pelvic cancers with acceptable morbidities, zero-rate mortality and equivalent oncologic outcomes. | Min Hoe Chew Yu-Ting Yeh Ee-Lin Toh Stephen Aditya Sumarli Ghee Kheng Chew Lui Shiong Lee Mann Hong Tan Tiffany Priyanthi Hennedige Shin Yi Ng Say Kiat Lee Tze Tec Chong Hairil Rizal Abdullah Terence Lin Hon Goh Mohamed Zulfikar Rasheed Kok Chai Tan Choong Leong Tang | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 1 |
| 5 | Pathogenic and Genetic Diversity of Magneporthe oryzae Populations from Sri Lanka显示文摘The present study was undertaken to determine the pathogenic and the genetic diversity of the isolates of M.oryzae collected from the wet,intermediate and dry zones of Sri Lanka with a view to develop rice varieties conferring durable resistance to rice blast.No significant morphological or growth variations existed amongst the isolates studied.The genetic diversity of isolates determined by carrying out Pot2 transposable element based on repetitive-PCR revealed that the majority of isolates (92%) clustered into a single group with 45.4% similarity.The existence of nine pathotypes was identified by observing the reaction type of isolates on 16 different rice lines.Pathotype 1 which was distributed in all zones affected only one differential line.Pathotype 2 which was able to infect six lines was restricted only to the dry zone of Sri Lanka.Of the 16 rice lines,seven lines,K3 (Pik-h),C101A51 (Piz5),K1 (Pita),C105TTP2L9 (Pita),K59 (Pit),Shin (Pish) and WHD-1S-75-1-127 (Pi9) had highly effective blast resistance.None of the isolates of the fungus showed any virulence against the seven lines.These seven blast resistant lines can be used in the breeding programmes in Sri Lanka for development of lines conferring durable resistance to rice blast. | Y J P K MITHRASENA WSS WIJESUNDERA R L C WIJESUNDERA D C WIMALASIRI R P N PRIYANTHI | 2012 | Rice science2012，19，3： | 0 |
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