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| 1 | Novel targeting approaches and signaling pathways of colorectal cancer: An insight显示文摘Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC. | Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 2 | What Clinicians Should Know About the 2014 Ebola Outbreak显示文摘 | Pritish K. Tosh Priya Sampathkumar | 2014 | Mayo Clinic Proceedings2014，，： | 2 |
| 3 | Absolute stereochemistry of the cadinenes from Eupatorium显示文摘 | Vishunu S S Nabin C B Pritish K C | 1986 | Trapezpideum Tetrahedron1986，42，： | 1 |
| 4 | Reported Gastrointestinal Endoscope Reprocessing Lapses: The Tip of the Iceberg显示文摘 | Alexandra M. Dirlam Langlay Cori L. Ofstead Natalie J. Mueller Pritish K. Tosh Todd H. Baron Harry P. Wetzler | 2013 | AJIC: American Journal of Infection Control2013，，： | 1 |
| 5 | Synthesis of some new steroidal -isoxazolines 显示文摘 | Pritish C Archana M D Papori G | 2005 | Steroid2005，70，4： | 1 |
| 6 | A model for the electrochemical reduction of metal oxides in molten salt electrolytes显示文摘 | Pritish Kar James W. Evans | 2008 | Electrochimica Acta2008，，2： | 1 |
| 7 | A shrinking core model for the electro-deoxidation of metal oxides in molten halide salts显示文摘 | Pritish Kar James W. Evans | 2008 | Electrochimica Acta2008，，16： | 1 |
| 8 | Influenza vaccines: from surveillance through production to protection显示文摘 | Pritish K Tosh M D Robert M | 2010 | Mayo Clinic Proceedings2010，85，3： | 1 |
| 9 | Novel technique for low-jitter dual-laser synchronization in a thin film deposition system 显示文摘 | Pritish Mukherjee John B Cuff Sarath Witanachchi | 2001 | Rev Sci Instrum2001，72，5： | 1 |
| 10 | Absolutestereochemistry of the cadinenes from Eupatorium adenophorum 显示文摘 | Vishunu S S Nabin C B Pritish K C | 1986 | Trapezpideum Tetrahedron1986，42，： | 1 |
| 11 | Reconstruction of palate with buccal fat pad secondary to resection of desmoplastic ameloblastoma显示文摘Desmoplastic ameloblastoma(DA)is an unusual variant of ameloblastoma exhibiting important differences in the anatomical distribution,radiographic features and histologic appearance compared with the classic type of ameloblastoma.The purpose of this paper is to report a case of DA in the anterior left maxilla and to describe a simple method of reconstruction with the use of buccal fat pad(BFP).BFP is an excellent choice for reconstruction of small to medium sized defects.It should be manipulated gently and hemostasis should be achieved meticulously during this surgery.It should not be sutured under tension. | Bhimappa Mallappa Rudagi Manjunatha Reddy Bandral Reshma Hammannawar Pritish Harish Padgavankar | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 12 | A Novel Single-Step Growth Process for the Deposition of CH3NH3PbI3-xClx Perovskite Films from CH3NH3Cl and PbI2 Precursors显示文摘 | Chaminda Hettiarachchi Nicholas Valdes Pritish Mukherjee Sarath Witanachchi | 2016 | 材料科学与工程(中英文A版)2016，6，5： | 0 |
| 13 | Scarf-related injuries at a major trauma center in northern India显示文摘PurposeScarf 是绕颈和肩膀穿的布的一长松开的片。尽管有这件衣服的文化协会,它是改变极恶的众多的损害事件的部分。在自行车的说的车轮中的松开的围巾的纠纷,三轮车,象甘蔗果汁一样的驾驶机器用机器制造的带, thresher,磨擦机器,等等在社会、工业的周围两个都被观察。这研究试图在北 India.MethodsFrom 2013 年 6 月在一个主要损伤中心调查围巾相关的损害到 2015 年 5 月,基于医院的未来的观察研究在与绕颈包含围巾的损害的模式在北印度介绍了 1 个损伤中心给水平的病人被做。人口统计的侧面,损伤的模式,作出贡献的因素,损害模式,和象早复杂并发症一样的早管理是 recorded.ResultsThere 76 损害直接与是的病人的吝啬的年龄从围巾被联系 32.4 年。最普通的主要因素正在旋转包含机器脚踏车 / 三轮车(46.1%) 的车轮,由驾驶的带列在后面机器(28.9%) 。损害的光谱是多样的,包括次要的磨损或撕裂,大撕裂(15.8%) ,破裂和脊骨损伤(18.4%) ,乱切的极限和切断和死亡(3.9%)(53.9%) 。更严重的损害模式被注意,带驱使 machines.ConclusionScarf 相关损害组成损伤的一个相当大的比例,与改变严厉的度。在盒子的重要比例的破坏后果为包括教育、立法的措施的一个预防计划支配电话。指向围巾相关的损害的迫切预防措施将帮助减少死亡和病态。 | Pritish Singh Ashok Kumar Vishal Shekhawat | 2017 | Chinese Journal of Traumatology2017，20，2： | 0 |
| 14 | A study of the COVID-19 epidemic in India using the SEIRD model显示文摘Background:The coronavirus pandemic(COVID-19)is causing a havoc globally,exacerbated by the newly discovered SARS-CoV-2 virus.Due to its high population density,India is one of the most badly effected countries from the first wave of COVID-19.Therefore,it is extremely necessary to accurately predict the state-wise and overall dynamics of COVID-19 to get the effective and efficient organization of resources across India.Methods:In this study,the dynamics of COVID-19 in India and several of its selected states with different demographic structures were analyzed using the SEIRD epidemiological model.The basic reproductive ratio Ra was systemically estimated to predict the dynamics of the temporal progression of COVID-19 in India and eight of its states,Andhra Pradesh,Chhattisgarh,Delhi,Gujarat,Madhya Pradesh,Maharashtra,Tamil Nadu,and Uttar Pradesh.Results:For India,the SEIRD model calculations show that the peak of infection is expected to appear around the middle of October,2020.Furthermore,we compared the model scenario to a Gaussian fit of the daily infected cases and obtained similar results.The early imposition of a nation-wide lockdown has reduced the number of infected cases but delayed the appearance of the infection peak significantly.Conclusion:After comparing our calculations using India’s data to the real life dynamics observed in Italy and Russia,we can conclude that the SEIRD model can predict the dynamics of COVID-19 with sufficient accuracy. | Rudra Banerjee Srijit Bhattacharjee Pritish Kumar Varadwaj | 2021 | Quantitative Biology2021，9，3： | 0 |
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