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| 1 | Reference quality assembly of the 3.5-Gb genome of Capsicum annuum from a single linked-read library显示文摘Linked-Read sequencing technology has recently been employed successfully for de novo assembly of human genomes,however,the utility of this technology for complex plant genomes is unproven.We evaluated the technology for this purpose by sequencing the 3.5-gigabase(Gb)diploid pepper(Capsicum annuum)genome with a single Linked-Read library.Plant genomes,including pepper,are characterized by long,highly similar repetitive sequences.Accordingly,significant effort is used to ensure that the sequenced plant is highly homozygous and the resulting assembly is a haploid consensus.With a phased assembly approach,we targeted a heterozygous F1 derived from a wide cross to assess the ability to derive both haplotypes and characterize a pungency gene with a large insertion/deletion.The Supernova software generated a highly ordered,more contiguous sequence assembly than all currently available C.annuum reference genomes.Over 83%of the final assembly was anchored and oriented using four publicly available de novo linkage maps.A comparison of the annotation of conserved eukaryotic genes indicated the completeness of assembly.The validity of the phased assembly is further demonstrated with the complete recovery of both 2.5-Kb insertion/deletion haplotypes of the PUN1 locus in the F1 sample that represents pungent and nonpungent peppers,as well as nearly full recovery of the BUSCO2 gene set within each of the two haplotypes.The most contiguous pepper genome assembly to date has been generated which demonstrates that Linked-Read library technology provides a tool to de novo assemble complex highly repetitive heterozygous plant genomes.This technology can provide an opportunity to cost-effectively develop high-quality genome assemblies for other complex plants and compare structural and gene differences through accurate haplotype reconstruction. | Amanda M.Hulse-Kemp Shamoni Maheshwari Kevin Stoffel Theresa A.Hill David Jaffe Stephen R.Williams Neil Weisenfeld Srividya Ramakrishnan Vijay Kumar Preyas Shah Michael C.Schatz Deanna M.Church Allen Van Deynze | 2018 | Horticulture Research2018，5，1： | 4 |
| 2 | Channel Coordination Mechanisms for Customer Satisfaction显示文摘 | Wujin Chu Preyas S. Desai | 1995 | Marketing Science1995，，4： | 2 |
| 3 | Competition in Durable Goods Markets: The Strategic Consequences of Leasing and Selling显示文摘 | Preyas S. Desai Devavrat Purohit | 1999 | Marketing Science1999，，1： | 2 |
| 4 | Competition in durable goods markets: The strategic consequences of leasing and selling显示文摘 | Desai Preyas S Devavrat P | 1999 | Marketing Science1999，，1： | 1 |
| 5 | The role of production lead time and demand uncertainty in marketing durable goods显示文摘 | Desai Preyas S Koenigsberg O Devavrat P | 2007 | Management Science2007，53，1： | 1 |
| 6 | A Matlab- based Modeling and Simulation Package for Electric and Hybrid Electric Vehicle Design 显示文摘 | Karen L B Mehrdad E Preyas K | 1999 | IEEE Transactions on Vehicular Technology1999，48，11： | 1 |
| 7 | Efficiency of mutual funds and portfolio performance measurement: A non-parametric approach显示文摘 | B.P.S. Murthi Yoon K. Choi Preyas Desai | 1997 | European Journal of Operational Research1997，，2： | 1 |
| 8 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 9 | Efficiency of mutual funds and portfolio performance measurement: A non-parametric approach显示文摘 | B.P.S. Murthi Yoon K. Choi Preyas Desai | 1997 | European Journal of Operational Research1997，，2： | 1 |
| 10 | When old is gold:the role of business longevity in risky situations显示文摘 | PREYAS S DESAI AJAY KALRA B P S MURTHI | 2008 | Journal of Marketing2008，，： | 1 |
| 11 | Efficiency of mutual funds and portfolio performance measurement: A non-parametric approach显示文摘 | Yoon K Choi Preyas Desai | 1997 | European Journal of Operational Research1997，98，： | 1 |
| 12 | Product differentiation and commonality in design: Balancing revenue and cost drivers显示文摘 | Preyas Desai Sunder Kekre Suresh Rdhakrishnan | 2001 | Management Science2001，47，1： | 1 |
| 13 | A MatlabBased Modeling and Simulation Package for Electric and Hybrid Electric Vehicle Design显示文摘 | Butler Karen L Ehsani Mehrdad Kamath Preyas | 1999 | IEEE Transactions on Vehicular Technology1999，48，6： | 1 |
| 14 | Music Downloads and the Flip Side of DRM 显示文摘 | Dinah A V Devavrat P Preyas S D | 2011 | Marketing Science2011，30，6： | 1 |
| 15 | Product Differentiation and Commonality in Design: Balancing Revenue and Cost Drivers显示文摘 | Preyas Desai Sunder Kekre Suresh Radhakrishnan Kannan Sriniva- san | 2001 | Management Science2001，47，1： | 1 |
| 16 | Multiple Messages to Retain Retailers Signaling New Product Demand 显示文摘 | PREYAS S DESAI | 2000 | Marketing Science2000，19，4： | 1 |
| 17 | The role of produetion lead time and demand uncertainty in marketing durable goods 显示文摘 | Preyas S Desai Oded Koenigsberg Devavrat Purohit | 2007 | Management Science2007，53，1： | 1 |
| 18 | A Matlab-Based Modeling and Simulation Package for Electric and Hybrid Electric Vehicle Design显示文摘 | Karen L Butler Mehrdad Ehsani Preyas Kamath | 1999 | IEEE Transactions on Vehicle Technology1999，48，6： | 1 |
| 19 | A Matlab-based modeling and simulation package for electric and hybrid electric vehicle design 显示文摘 | Butler K L Ehsani M Kamath Preyas | 1999 | IEEE Transactions on Vehicular Technology1999，48，6： | 1 |
| 20 | Multiple Messages to Retain Retailers: Signaling New Product Demand显示文摘 | Preyas S. Desai | 2000 | Marketing Science2000，，4： | 1 |
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