|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Utility of flexible fiberoptic bronchoscopy for critically ill pediatric patients:A systematic review显示文摘AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and EMBASE databases through July 2014 for English language publications studying FFB performed in the intensive care unit in children < 18 years old. We identified 666 studies, of which 89 full-text studies were screened for further review. Two reviewers independently determined that 27 of these studies met inclusion criteria and extracted data. We examined the diagnostic yield of FFB among upper and lower airway evaluations, as well as the utility of bronchoalveolar lavage(BAL). RESULTS: We found that FFB led to a change in medical management in 28.9%(range 21.9%-69.2%) of critically ill children. The diagnostic yield of FFB was 82%(range 45.2%-100%). Infectious organisms were identified in 25.7%(17.6%-75%) of BALs performed, resulting in a change of antimicrobial management in 19.1%(range: 12.2%-75%). FFB successfully reexpanded atelectasis or removed mucus plugs in 60.3%(range: 23.8%-100%) of patients with atelectasis. Adverse events were reported in 12.9%(range: 0.5%-71.4%) of patients. The most common adverse effects of FFB were transient hypotension, hypoxia and/or bradycardia that resolved with minimal intervention, such as oxygen supplementation or removal of the bronchoscope. Serious adverse events were uncommon; 2.1% of adverse events required intervention such as bag-mask ventilation or intubation and atropine for hypoxia and bradycardia, normal saline boluses for hypotension, or lavage and suctioning for hemorrhage. CONCLUSION: FFB is safe and effective for diagnostic and therapeutic use in critically ill pediatric patients. | Aida Field-Ridley Viyeka Sethi Shweta Murthi Kiran Nandalike Su-Ting T Li | 2015 | World Journal of Critical Care Medicine2015，4，1： | 12 |
| 2 | Recent advances in biomaterials for 3D scaffolds: A review显示文摘Considering the advantages and disadvantages of biomaterials used for the production of 3D scaffolds for tissue engineering,new strategies for designing advanced functional biomimetic structures have been reviewed.We offer a comprehensive summary of recent trends in development of single-(metal,ceramics and polymers),composite-type and cell-laden scaffolds that in addition to mechanical support,promote simultaneous tissue growth,and deliver different molecules(growth factors,cytokines,bioactive ions,genes,drugs,antibiotics,etc.)or cells with therapeutic or facilitating regeneration effect.The paper briefly focuses on divers 3D bioprinting constructs and the challenges they face.Based on their application in hard and soft tissue engineering,in vitro and in vivo effects triggered by the structural and biological functionalized biomaterials are underlined.The authors discuss the future outlook for the development of bioactive scaffolds that could pave the way for their successful imposing in clinical therapy. | Maria P.Nikolova Murthy S.Chavali | 2019 | Bioactive Materials2019，4，1： | 11 |
| 3 | 不同时期颅内动脉瘤患者入院后再破裂风险的对照研究显示文摘目的 对比分析不同时期住院治疗的颅内动脉瘤患者的临床资料,探讨入院后动脉瘤再破裂率下降的可能原因.方法 回顾性纳入2005年1月至2008年12月(2005~2008年组,458例)和2013年1月至2014年12月(2013~2014年组,1 446例)四川大学华西医院神经外科收治的颅内动脉瘤性蛛网膜下腔出血(aSAH)患者.比较2组患者入院后动脉瘤的再破裂率,分析年龄、性别、Hunt-Hess分级、入院的收缩压、是否使用抗纤溶药物、动脉瘤部位、院前等待时间、术前等待时间及总体住院时间等指标对动脉瘤再破裂的影响.结果 2005~2008年组入院后动脉瘤的再破裂率为13.8% (63/458),2013 ~ 2014年组为2.8% (40/1 446),差异有统计学意义(P<0.01).2005~2008年组与2013~2014年组院前等待时间中位数(四分位数间距)分别为4(9)、1(4)d;术前等待时间分别为5(4)、3(2)d;整体住院时间分别为14(9)、11(7)d,差异均有统计学意义(均P<0.01).其余指标比较差异均无统计学意义(均P >0.05).结论 提高动脉瘤处理效率是减少入院后再破裂风险及提高患者预后的重要手段. | 伍聪 Narasimha Murthy Trishul 梁锐超 王焱超 李进 贺民 | 2017 | 中华神经外科杂志2017，33，8： | 8 |
| 4 | 结膜滤过泡组织病理学特性显示文摘目的:描述并比较在修复小梁切除术和由于疏忽造成的滤过泡时得到的的结膜的组织学特征并评价抗纤维变性药物的作用。方法:我们对经过晚期滤过泡修复的28只眼的结膜标本采用常规石蜡制作的方法和光学显微镜下检查进行仔细观察:19只眼为渗漏的小梁切除术滤过泡,5只眼为无渗漏的小梁切除术滤过泡,4只眼为由于疏忽造成的滤过泡。定量分析的组织学特征包括结膜上皮的厚度,基质血管供应,鳞状组织化生,基质炎症细胞浸润和杯状细胞的密度。并且分析了手术类型,存在渗漏,先前的局部用药,应用抗纤维化药物都与组织学检查所见并置对比。结果:与由于疏忽造成的滤过泡的对照组相比,小梁切除术的滤过泡(渗漏的和无渗漏的)显示上皮的厚度(P〈0.02),杯状细胞的密度(P〈0.001)和血管供应(P〈0.001)全部降低。接受过抗纤维化药物的结膜比先前未受抗纤维化药物影响的结膜的上皮细胞层数更少(P〈0.05)。结论:小梁切除术后切除的薄的滤过泡的组织学分析证明上皮的厚度和杯状细胞的密度与由于疏忽造成的滤过泡相比均降低。与正常结膜相比。 | Brian A. Francis Lee T. Du Kathryn Najafi Raghu Murthy Usha Kurumety Narsing Rao Don S. Minckler 李航(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 8 |
| 5 | Adventitious Roots and Secondary Metabolism显示文摘Plants are a rich source of valuable secondary metabolites and in the recent years plant cell, tissue and organ cultures have been developed as an important alternative sources for the production of these compounds. Adventitious roots have been successfully induced in many plant species and cultured for the production of high value secondary metabolites of pharmaceutical, nutraceutical and industrial importance. Adoption of elicitation methods have shown improved synthesis of secondary metabolites in adventitious root cultures. Development of large-scale culture methods using bioreactors has opened up feasibilities of production of secondary metabolites at the industrial levels. In the present review we summarize the progress made in recent past in the area of adventitious root cultures for the production of secondary metabolites. | Hosakatte Niranjana Murthy Eun Joo Hahn Kee Yoeup Paek | 2008 | 生物工程学报2008，24，5： | 7 |
| 6 | Performance evaluation of up-flow anaerobic sludge blanket(UASB) reactor for treatment of paper mill wastewater显示文摘The present study deals with the performance evaluation of the UASB reactor under varied organic loading rate(OLR) for the treatment of paper mill wastewater. The sludge granulation process started after 120 days from the start-up period. Sludge granules size was found to be 0 8 mm at OLR of 1 72 kgCOD/(m 3·d), which reached maximum size of about 1 0 to 1 2 mm at OLR of 2 1 kgCOD/(m 3·d). At the end of initial OLR of 1 0 kgCOD/(m 3·d) the VSS concentration was 12 86 gVSS/L, which got increased to 38 05 gVSS/L at the end of an OLR 2 1 kgCOD/(m 3·d). Most of the times VFA recorded were well within the limit of VFA reported in anaerobic fermentation process. Many times the pH observed was between 6 5 and 7 8, which is more favorable for any anaerobic process. It is also found that pH within the reactor increases along with the height of reactor. The total maximum biogas production was found to be 0 40 L/gCOD removals at OLR of 2 1 kgCOD/(m 3·d) and the maximum BOD removal at this stage was observed to be 90%. | M. Mahadevaswamy B.M. Sadashiva Murthy A.R. Girijamma | 2004 | Journal of Environmental Sciences2004，16，2： | 7 |
| 7 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 8 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 9 | Separation and estimation of nanofiltration membrane transport parameters for cerium and neodymium显示文摘Lanthanides are widely used in various commercial applications, which results in public exposure to them, and it is a matter of concern. Many methods were used to remove lanthanides from wastewaters generated from their commercial use. In the present work, nanofiltration membrane process was used to remove the cerium and neodymium from their respective feed solutions. The feed and permeates were analyzed for solute concentration by inductively coupled plasma-atomic emission spectroscopy. Irreversible thermodynamics Spiegler-Kedem model, in combination with the film theory, was used to estimate the membrane transport parameters, viz., reflection coefficient of membrane and solute permeability, and mass transfer coefficient to study their dependence on feed solute concentration. | Zagabathuni Venkata Panchakshari MURTHY Anshul CHOUDHARY | 2012 | Rare Metals2012，31，5： | 4 |
| 10 | Customer value, satisfaction, loyalty, and switching costs: An illustration from a business-to-business service context显示文摘 | Shun Yin Lam Venkatesh Shankar M. Krishna Erramilli Bvsan Murthy | 2004 | Journal of the Academy of Marketing Science2004，，3： | 4 |
| 11 | Concurrent removal of intravitreal lens fragments after phacoemulsification with pars plana vitrectomy prevents development of retinal detachment显示文摘AIM: To evaluate the outcomes of 'concurrent vitrectomy' to retrieve dislocated lens fragment during phacoemulsification.METHODS: In a retrospective, observational case series, data of patients who underwent 'concurrent' pars plana vitrectomy(PPV) for dislocated lens fragments between the period 2000 and 2008 were reviewed. Data collected included patient demographics, pre-operative visual acuity, intra-operative occurrence of retinal breaks, duration of follow up, post-operative intraocular pressure, final best-corrected visual acuity(BCVA),presence of cystoid macular edema(CME) and occurrence of rhegmatogenous retinal detachment(RRD).· RESULTS: A total of 58 eyes of 58 patients were included in the study. At 12 mo the mean postoperative BCVA was log MAR 0.17(20/30) with a range of log MAR0 to 0.69(20/20 to 20/100), with 96.6%(56/58) of patients showing post- operative improvement in visual acuity(P =0.005). None of the patients developed postoperative retinal detachment, endophthalmitis or non-resolving uveitis at 12 mo.CONCLUSION: Our study results suggest concurrent PPV for retained lens fragments after cataract surgery is beneficial and may decrease the risk of glaucoma and prevent development of RRD. | Kakarla V Chalam Ravi K Murthy Joshua C Priluck Vijay Khetpal Shailesh K Gupta | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 12 | Characteristics of landslide in Koshi River Basin,Central Himalaya显示文摘Koshi River basin, which lies in the Central Himalayas with an area of 71,500 km2, is an important trans-boundary river basin shared by China, Nepal and India. Yet, landslide-prone areas are all located in China and Nepal, imposing alarming risks of widespread damages to property and loss of human life in both countries. Against this backdrop, this research, by utilizing remote sensing images and topographic maps, has identified a total number of 6877 landslides for the past 23 years and further examined their distribution, characteristics and causes. Analysis shows that the two-step topography in the Himalayan region has a considerable effect on the distribution of landslides in this area. Dense distribution of landslides falls into two regions: the Lesser Himalaya(mostly small and medium size landslides in east-west direction) and the TransitionBelt(mostly large and medium size landslides along the river in north-south direction). Landslides decrease against the elevation while the southern slopes of the Himalayas have more landslides than its northern side. Change analysis was carried out by comparing landslide distribution data of 1992, 2010 and 2015 in the Koshi River basin. The rainfallinduced landslides, usually small and shallow and occurring more frequently in regions with an elevation lower than 1000 m, are common in the south and south-east slopes due to heavy precipitation in the region, and are more prone to the slope gradient of 20°~30°. Most of them are distributed in Proterozoic stratum(Pt3ε, Pt3 and Pt2-3) and Quaternary stratum. While for earthquake-induced landslides, they are more prone to higher elevations(2000~3000 m) and steeper slopes(40°~50°). | ZHANG Jian-qiang LIU Rong-kun DENG Wei KHANAL Narendra Raj GURUNG Deo Raj MURTHY Manchiraju Sri Ramachandra | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 13 | Design,synthesis and in vitro antibacterial activities of methyl-4-((substituted phenyl)[6H-indolo(2,3-b)quinoxalin-6-yl]methyl-amino)benzoate derivatives显示文摘一系列新 methyl-4-(( 代替的苯基)[6H-indolo (2,3-b ) quinoxalin-6yl ] methylamino ) 安息香酸盐衍生物被综合了并且为他们 9 个不同细菌的种类上的抗菌剂活动的 assayed。在屏蔽混合物之中, 2e2g 展出了与标准药相比的禁止的活动采用了的有势力,值得进一步的调查。 | Yellajyosula Lakshmi Narasimha Murthy Nagalakshmi Karthikeyan Govindh Boddeti Bhagavathula S.Diwakar E.Rajendra Singh | 2011 | Chinese Chemical Letters2011，22，5： | 4 |
| 14 | neuroendocrine 的罐头成像模式肝的转移预言反应 yttruim-90 radioembolotherapy?显示文摘 AIM:To evaluate the response to treatment in patients with neuroendocrine tumor liver metastases following yttrium-90 ( 90 Y) radioembolotherapy, as a function of image patterns at presentation for 90 Y radioembolotherapy. METHODS: The study cohort consisted of patients with hepatic metastatic neuroendocrine tumors treated with 90 Y at our institution during a two-year time period. Hepatic metastases were evaluated on a pretherapy study assessing relative arterial enhancement compared to liver, lesion size, necrosis of the lesion, and associated tumor burden in the liver. We used six response criteria: Response Evaluation Criteria in Solid Tumors (RECIST) size, World Health Organization (WHO) size, European Association for the Study of the Liver (EASL) necrosis guidelines, Choi size, Choi necrosis and combination of Choi size and necrosis. RESULTS: About 65 lesions in 17 patients met study criteria and formed the cohort. Statistically significant response was found for lesions < 5 cm vs those ≥5 cm with RECIST (P = 0.04), WHO (P = 0.002) and combined Choi criteria (P = 0.02). Hyperenhancing lesions demonstrated greater response only with the Choi size criteria (P = 0.04). Lesions with ≤ 50% necrosis on the pre-scan had statistically significant greater response with the Choi necrosis criteria (P = 0.01). There was no statistical significance for response comparing lesions < 2 cm vs ≥ 2 cm or in comparing the degrees of tumor burden. CONCLUSION: Based on our findings in this study, it is suggested that initial imaging findings, as listed above, are not a good predictor of response to 90 Y radioembolization. | Julia Neperud Armeen Mahvash Naveen Garg Ravi Murthy Janio Szklaruk | 2013 | World Journal of Radiology2013，5，6： | 3 |
| 15 | 结肠缺血再灌注损伤和5-ASA的治疗作用显示文摘选择血清血栓素(TXB_2)和组织Even蓝岔量为指标,观察大鼠右半结肠缺血再灌注损伤及5-氨基水杨酸(5-ASA)的治疗作用。结果显示,缺血再灌注后结肠组织Even蓝含量及血清中TXB_2的浓度明显增高。结肠内灌注5-ASA后,Even蓝含量和TXB_2浓度下降,以30mg/kg的剂量最明显。以上结果提示,足够剂量的5-ASA有防治结肠缺血再灌注损伤的作用。其作用机理同5-ASA减少氧自由基形成有关。 | 齐清会 Murthy SNS | 1995 | 天津医药1995，23，2： | 3 |
| 16 | Assessment of pot-hole subsidence risk for Indian coal mines显示文摘Ground subsidence induced by extraction of coal seam belowground brings about changes in surface environment leading to trough and pot-hole subsidence.Pot-hole subsidence is extremely hazardous and does not give any prior indication before its occurrence.In India,several pot-holes have occurred in the coal mines of South Eastern Coalfields Limited triggering the need for in-depth studies.In line with the requirement,literature review and field investigations were conducted to develop an in-depth understanding of various parameters influencing the occurrence of pot-holes.The critical parameters identified were rock to soil ratio,depth to height of extraction ratio,brittleness index of rock and rock density.Risk assessment of pot-hole subsidence has been done by developing an empirical rating approach named as pot-hole subsidence rating(PHSR),involving the critical parameters with suitable corrections for certain structural and mining conditions to obtain corrected PHSR(CPHSR).CPHSR was then applied for all the 34pot-holes studied and it was found that all the pot-holes fall under Class I and Class II category of risk representing a very high to high risk class.An effort was made for the estimation of pot-hole depth utilizing the developed CPHSR in both the development and depillaring cases.The developed approach was found to yield consistent results in pot-hole depth prediction. | Lokhande D.Ritesh Murthy Vemavarapu M.S.R. Vellanky Venkateswarlu Singh B.Kalendra | 2015 | International Journal of Mining Science and Technology2015，25，2： | 3 |
| 17 | Synthesis of novel isoxazolyl bis-thiazolo[3,2-a]pyrimidines显示文摘A new synthetic strategy for the synthesis of novel 3-(3-(3-methyl-4-nitroisoxazol-5-yl)-2-phenyl-1-(5,7-diaryl-7H-thiazolo[3,2-a]pyrimidin-3-yl)propyl)-5,7-diaryl-7H-thiazolo[3,2-a] pyrimidines(7a-i) analogues is described.Reaction of 3-(2(3-methyl-4-nitroisoxazole-5-yl)-1-phenylethyl)pentane-2,4-dione(3) with two moles of thiourea in presence of iodine and CuO afforded 4-(1-(2-aminothiazol-4-yl)-3-(3-methyl-4-nitroisoxazol-5-yl)-2-aryl propyl-thiazol-2-amine(5).Compound 5 on reaction with two moles of chalcone(6) furnished novel 3-(3-(3-methyl-4-nitroisoxazol-5-yl)-2-phenyl-1-(5,7-diaryl-7H-thiazolo[3,2a]pyrimidin-3-yl)propyl)-5,7-diaryl-7H-thiazolo[3,2-a] pyrimidines(7a-i). | E.Rajanarendar S.Ramakrishna K.Rama Murthy | 2012 | Chinese Chemical Letters2012，23，8： | 3 |
| 18 | Prediction of Compressive Strength of Self-Compacting Concrete Using Intelligent Computational Modeling显示文摘In the present scenario,computational modeling has gained much importance for the prediction of the properties of concrete.This paper depicts that how computational intelligence can be applied for the prediction of compressive strength of Self Compacting Concrete(SCC).Three models,namely,Extreme Learning Machine(ELM),Adaptive Neuro Fuzzy Inference System(ANFIS)and Multi Adaptive Regression Spline(MARS)have been employed in the present study for the prediction of compressive strength of self compacting concrete.The contents of cement(c),sand(s),coarse aggregate(a),fly ash(f),water/powder(w/p)ratio and superplasticizer(sp)dosage have been taken as inputs and 28 days compressive strength(fck)as output for ELM,ANFIS and MARS models.A relatively large set of data including 80 normalized data available in the literature has been taken for the study.A comparison is made between the results obtained from all the above-mentioned models and the model which provides best fit is established.The experimental results demonstrate that proposed models are robust for determination of compressive strength of self-compacting concrete. | Susom Dutta ARamachandra Murthy Dookie Kim Pijush Samui | 2017 | Computers, Materials & Continua2017，，2： | 3 |
| 19 | Sperm counts and sperm sex ratio in male infertility patients显示文摘在最近的年里,调查者在许多工业化国家向男出生的一个衰退比例注意了一个趋势。当人们忍受决定性的染色体时,它与授精或流产相关的女搭挡的角色可以也改变性比率。我们试图由直接检验他的精子的性染色体决定一个人的第二等的性比率(F1 产生) 。我们为在 situ 杂交(鱼) 经历了精液荧光的所有人检验了我们的男不孕诊所数据库。人口统计的病人和精液参数被记录。摆平 Chi 的分析被用来比较性比率(Y 染色体 / 总数染色体) 。Multivariable 逻辑回归被用来预言在财务以后拥有一个忍受 Y 精子为的机会人口统计并且精液参数。185 个人的一个总数经历了精子鱼。为全部队, Y 忍受染色体的精子的比例是 51.5 %。有不到 500 万个能动精子的人有 Y 忍受染色体的精子的一个显著地更低的比例(50.8 %) 与有更高的精子计数的人相比(51.6 %P=0.02 ) 。在 multivariable 调整以后,更高的精子集中,全部的能动精子计数和精液体积显著地增加了有 Y 的机会忍受染色体的精子(P< 0.01 ) 。作为一个人的精子生产衰落,那么做 Y 忍受染色体的精子的比例。因此,一个人的繁殖潜力可以预言他的能力到陛下男性后代。 | Michael L Eisenberg Lata Murthy Kathleen Hwang Dolores J Lamb Larry I Lipshultz | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 20 | Establishment of Withania somnifera Hairy Root Cultures for the Production of Withanolide A显示文摘Withania sominifera (Indian ginseng) was transformed by Agrobacterium rhizogenes. Explants from seedling roots, stems, hypocotyls, cotyledonary nodal segments, cotyledons and young leaves were inoculated with A. rhizogenes strain R1601. Hairy (transformed) roots were induced from cotyledons and leaf explants. The transgenic status of hairy roots was confirmed by polymerase chain reaction using nptII and rolB specific primers and, subsequently, by Southern analysis for the presence of nptII and rolB genes in the genomes of transformed roots. Four clones of hairy roots were established; these differed in their morphology. The doubling time of faster growing cultures was 8-14 d with a fivefold increase in biomass after 28 d compared with cultured, non-transformed seedling roots. MS-based liquid medium was superior for the growth of transformed roots compared with other culture media evaluated (SH, LS and N6), with MS-based medium supplemented with 40 g/L sucrose being optimal for biomass production. Cultured hairy roots synthesized withanolide A, a steroidal lactone of medicinal and therapeutic value. The concentration of withanolide A in transformed roots (157.4 μg/g dry weight) was 2.7-fold more than in non-transformed cultured roots (57.9 μg/g dry weight). | Hosakatte N. Murthy Camelia Dijkstra Paul Anthony Daniel A. White Mike R. Davey J. Brian Power Eun J. Hahn Kee Y. Paek | 2008 | Journal of Integrative Plant Biology2008，50，8： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员