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| 1 | Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF显示文摘Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive procedures.Point-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ratio.Methods:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion requirements.We assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC strategy.Results:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion algorithms.Of 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 patients.Correction of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,respectively.Conclusions:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical bleeding.Trial Registration:NCT04332484. | Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 7 |
| 2 | Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits显示文摘 | Chatterton JE Awobuluyi M Premkumar LS | 2002 | Nature2002，415，： | 2 |
| 3 | Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive MIA binding and RT-PCR analysis 显示文摘 | Premkumar DRD Lin CW | 1998 | Mol Brain Res1998，58，： | 1 |
| 4 | Excitatory Glycine Receptors Containing the NR3 Family of NMDA Receptor Subtmits显示文摘 | Chatterton J E Awobuluyi M C Premkumar L S | 2002 | Nature2002，415，6873： | 1 |
| 5 | Synthesis and electrochemical behaviour of tin oxide for use as anode in lithium rechargeable batteries 显示文摘 | Sivashanmucam A Premkumar T Gopukumar S | 2005 | Journal of Applied Electrochemistry2005，35，： | 1 |
| 6 | Ventilatory strategies for the extremely premature infant 显示文摘 | Greenough A Premkumar M Patel D | 2008 | Paediatr Anaesth2008，18，5： | 1 |
| 7 | Studies on thermal,mechanical and morphological behaviour of eaprolaetam blocked methylenediphenyl diisoeyanate toughened bismaleimide modified epoxy matrices显示文摘 | Premkumar S Karikal Chozhan C Alagar M | 2008 | European Polymer Journal2008，44，8： | 1 |
| 8 | An unusual halo tolerant alpha-type carbonic anhydrate from the alga Unadilla Salina functionally expressed in Escherichia coli显示文摘 | Premkumar L Bageshwar UK Gokhman I | 2003 | Protein Expr Purif2003，28，1： | 1 |
| 9 | Vascular endothelial growth factorin Alzheimer's disease and experimeutal Cerebral ischemia显示文摘 | Kalaria R N Cohen D L Premkumar D R | 1998 | Brain Res Mol Brain Res1998，621，： | 1 |
| 10 | Prevalence of diabetic retinopathy in urban India: the Chennai Urban Rural Epidemiology Study (CURES) eye study, I 显示文摘 | Rema M Premkumar S Anitha B | 2005 | Invest Ophthalmol Vis Sci2005，46，7： | 1 |
| 11 | Novel materials for electronic packaging and thermal management, Conference Review显示文摘 | Hunt W H Premkumar M K | 1992 | Journal of Materials1992，44，7： | 1 |
| 12 | Understanding chan- ges in belief and attitude toward information technology usage : a theoretical model and longitudinal test 显示文摘 | BHATYACHERJEE A PREMKUMAR G | 2004 | MIS Quarterly2004，28，2： | 1 |
| 13 | The role of interorganizational and organizational factors on the decision mode for adoption of interorganizational systems显示文摘 | Premkumar G Ramamurthy K | | 0，，03： | 1 |
| 14 | Testicular adrenal rest tumor in congenital adrenal hyperplasia:comparison of MR imaging and sonographic findings显示文摘 | Avila NA Premkumar A Merke DP | 1999 | AJR Am J Roentgenol1999，172，4： | 1 |
| 15 | The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line 显示文摘 | Levin E Premkumar A Veenman L | 2005 | Biochemistry2005，44，29： | 1 |
| 16 | Kombucha SCOBY-based carbon and graphene oxide wrapped sulfur/polyacrylonitrile as a high-capacity cathode in lithium-sulfur batteries显示文摘Hierarchically-porous carbon nano sheets were prepared as a conductive additive for sulfur/polyacrylonitrile(S/PAN)composite cathodes using a simple heat treatment.In this study,kombucha(that was derived from symbiotic culture of bacteria and yeast)carbon(KC)and graphene oxide(GO)were used as a carbon host matrix.These rational-designed S/PAN/KC/GO hybrid composites greatly suppress the diffusion of polysulfides by providing strong physical and chemical adsorption.The cathode delivered an initial discharge capacity of 1652 mAh·g^-1 at a 0.1 C rate and a 100th cycle capacity of 1193 mAh·g^-1.The nano sheets with embedded hierarchical pores create a conductive network that provide effective electron transfer and fast electrochemical kinetics.Further,the nitrogen component of PAN can raise the affinity/interaction of the carbon host with lithium polysulfides,supporting the cyclic performance.The results exploit the cumulative contribution of both the conductive carbon matrix and PAN in the enhanced performance of the positive electrode. | Krishnaveni Kalaiappan Subadevi Rengapillai Sivakumar Marimuthu Raja Murugan Premkumar Thiru | 2020 | Frontiers of Chemical Science and Engineering2020，14，6： | 1 |
| 17 | Properties of exogenously added GPI-anchored proteins following their incorporation into cells显示文摘 | Premkumar DR Fukuoka Y Sevlever D | 2001 | J Cell Biochem2001，82，2： | 1 |
| 18 | Novel mutations in the calcium sensing receptor gene in tropical chronic pancreatitis in India显示文摘 | Elango E. Murugaian Ram Mohan R. Premkumar Lakshmi Radhakrishnan Balakrishnan Vallath | 2008 | Scandinavian Journal of Gastroenterology2008，，1： | 1 |
| 19 | Development of super - hydrophilicity on nitrogendoped TiO2 thin film surface by photoelectrochemical method under visible light 显示文摘 | Premkumar J | 2004 | Chem Mater2004，16，21： | 1 |
| 20 | Downregulation of transient receptor potential melastatin 8by protein kinase C mediated dephosphorylation显示文摘 | Premkumar L S Raisinghani M Pingle S C Long C Pimentel F | 2005 | J Neurosci2005，25，11： | 1 |
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