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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection显示文摘AIM: To assess the diagnostic accuracy,of aminotransferase-to-platelet ratio index(APRI) alone and with antischistosomal antibody(Ab) in patients with hepatitis C virus(HCV) and schistosomiasis coinfection. METHODS: This retrospective study included medical records of three hundred and eighty three Egyptianmen patients who had undergone percutaneous liver biopsy between January 2006 to April 2014 in tertiary care hospital in Qatar for diagnosis or monitoring purpose were selected. Data of patients > 18 years of age were included in the study. The values of HCV RNA titer and antischistosomal antibody titer were also taken into consideration. Patients were excluded from the study if they had any other concomitant chronic liver disease,including; history of previous antiviral or interferon therapy,immunosuppressive,therapy,chronic hepatitis B infection,human immunodeficiency virus co-infection,autoimmune hepatitis,decompensated liver disease,hepatocellular carcinoma,prior liver transplantation,and if no data about the liver biopsy present. RESULTS: Median age of patients was 46 years. About 7.1% had no fibrosis,whereas 30.4%,37.5%,20.4%,and 4.6% had fibrosis of stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ respectively. In bivariate analysis,APRI score,levels of AST,platelet count and age of patient showed statistically significant association with liver fibrosis(P < 0.0001); whereas antischistosomal antibody titer(P = 0.52) and HCV RNA titer(P = 0.79) failed to show a significant association. The respective AUC values for no fibrosis,significant fibrosis,severe fibrosis and cirrhosis of APRI score were 63%,73.2%,81.1% and 88.9% respectively. This showed good sensitivity and specificity of APRI alone for grading of liver fibrosis. But the inclusion of anti-Schistosoma antibody did not improve the prediction of fibrosis stage. CONCLUSION: The study results suggest that noninvasive biochemical markers like APRI are sensitive and specific in diagnosing the degree of fibrosis and cirrhosis in patients with coinfection of HCV and schistosomiasis as compared to biopsy. The addition of antischistosomal Ab to APRI did not improve sensitivity for predicting the degree of cirrhosis. | Moutaz Derbala Mohammed Elshiekh Elbadri Aliaa Mohamed Amer Saad Al Kaabi Khaleel Hassan Sultan Yasser Medhat Kamel Eman Hassan Satti Elsayed Tony Yervant Avades Prem Chandra Fatma M Shebl | 2015 | World Journal of Gastroenterology2015，21，46： | 2 |
| 3 | An ant algorithm for the single row layout problem in flexible manufacturing systems显示文摘 | SOLIMANPUR M VRAT Prem | 2003 | Computers and Operations Research2003，32，3： | 1 |
| 4 | NO,ROS,and cell death associated with caspase-like activ-ity increase in stress-induced microspore embryogene-sis of barley显示文摘 | Rodriguez-serrano M Barany I Prem D | 2012 | J Exp Bot2012，63，5： | 1 |
| 5 | Soft tissue Ilizarov correction of congenital talipes equinovarus 5 to 10 years postsurgery显示文摘 | Prem H Zenios M Farrel R | 2007 | J Pediatr Orthop2007，2，： | 1 |
| 6 | Cure Ki- netics and Sorption Charact eristics of Neoprene-Based Rub- ber Ferrite Composites显示文摘 | Prem a K H Kurian P Anantharaman M R | 2010 | International Journal of Polymeric Materials2010，59，3： | 1 |
| 7 | Pediatric staghom calculi :the role ofextracorporeal shock wave lithotripsy monotherapy With special reference to ureteral stenting显示文摘 | AL-Busaidy SS Prem AR Medhat M | 2003 | JU ml2003，169，2： | 1 |
| 8 | Pediatric staghorn calculi: the role of extracorporeal shock wave lithotripsy monotherapy with special reference to ureteral stenting显示文摘 | Al-Busaidy S S Prem A R Medhat M | 2003 | J Urol2003，169，2： | 1 |
| 9 | Soft tissue Ilizarov correction of congential talipes equinovarus-5 to 10 year postsurgery显示文摘 | Prem H Zenios M Farrell R | 2007 | J Pediatr Orthop2007，27，2： | 1 |
| 10 | Paediatric ureteroscopy for ureteric calculi:a 4-year experience显示文摘 | Al-Busaidy SS Prem AR Medhat M | 1997 | BJU Int1997，80，5： | 1 |
| 11 | An Ant Algorithm for the Single Row Layout Problem in Flexible Manufacturing Systems 显示文摘 | M Solimanpura Prem Vratb Ravi Shankar | 2005 | Computers & Operations Research2005，32，3： | 1 |
| 12 | Controversies con- cerning diagnostic guidelines for anomalies of the enteric nervous system: A report from the fourth International Sym- posium on Hirschsprung's disease and related neurocristopa- thies 显示文摘 | Giuseppe M Alessio PP Prem P | 2005 | Journal of Pediatric Surgery2005，40，： | 1 |
| 13 | The role of glutamine in skeletal muscle ischemia reperfusion injury in the rat bind limb model显示文摘 | Prem JT Eppinger M Lemmon G | 1999 | Am J Surg1999，178，2： | 1 |
| 14 | Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140显示文摘 | Prem N Gupta Aditya Pattani Rhonda M Curran | 2012 | Eur J Pharm Sci2012，46，5： | 1 |
| 15 | PeDiatric stag-horn calculi:the role of extracorporeal shock wave lithotripsy monotherapy with special reference to ureteral stenting显示文摘 | AL BUSAIDY SS PREM AR MEDHAT M | | 0，，02： | 1 |
| 16 | Pedhatric ureteroscopy for ureteric calculi:a 4 year experience显示文摘 | AL Busaidy SS Prem AR Medhat M | 1997 | Br J Urol1997，80，5： | 1 |
| 17 | An ant algorithm for the single row layout problem in flexible manufacturing systems显示文摘 | M Solimanpur Prem Vratb Ravi Shankarc | 2005 | Computers & Operations Research2005，32，3： | 1 |
| 18 | Pediatric staghorn calcu- li: the role of extracorporeal shock wave lithotripsy monotherapy with special reference to ureteral stenting显示文摘 | A1 - Busaidy SS Prem AR Medhat M | 2003 | J Urol2003，169，2： | 1 |
| 19 | Dynamics of: the Julia set and bifurcation显示文摘 | KAPOOR G P PREM M G RASAD I | 1998 | Erg Th & Dyn Sys1998，18，： | 1 |
| 20 | Pediatric staghorn calculi:the role of extracorporeal shock wave lithotripsy monotherapy with special reference to ureteral stenting显示文摘 | AI-Busaidy SS Prem AR Medhat M | | 0，，02： | 1 |
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