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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy显示文摘Hepatitis C virus(HCV)infection represents an important public health problem worldwide.Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.Virus molecular evolution plays an important role in HCV transmission,disease progression and therapy outcome.The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and compartmentalization.These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner.Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV.As a result,superior sustained viral responses have been attained.The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era. | Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 3 | Chronic hepatitis C virus infection:Serum biomarkers inpredicting liver damage显示文摘Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus(HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C(CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are(1) the physical ones based on imaging techniques; and(2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss:(1) class?Ⅰ?serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes;(2) class Ⅱ biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and(3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of HCV infection. We highlight in this review the evidence behind the use of these markers and assess the diagnostic accuracy as well as advantages, limitations, and application in clinical practice of each test for predicting liver damage in CHC. | Pamela Valva Daniela A Ríos Elena De Matteo Maria V Preciado | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 4 | Effect of low temperature tempering prior cryogenic treatment on carburized steels显示文摘 | Preciado M Bravo P M Alegre J M | 2006 | Journal of Materials Processing Technology2006，176，1： | 1 |
| 5 | Separation of human X and Y spermatozoa by albumin gradients and Sephadex chromatography显示文摘 | Quinlivan WL K Preciado TL Long | 1982 | Fertil Steril1982，37，1： | 1 |
| 6 | Simulation Procedure of High Pressure Vessels Using the Wire Winding Technique 显示文摘 | Alegre J M Bravo P Preciado M Solaguren-Beascoa M | 2010 | Engineering Failure Analysis2010，17，1： | 1 |
| 7 | A randomized intervention of reminder letter for human papillomavirus vaccine series completion 显示文摘 | Chao C Preciado M Slezak J | 2015 | J Adolesc Health2015，56，1： | 1 |
| 8 | Single-stage tracheal resection for severe tracheal stenosis in older children 显示文摘 | Preciado D Cotton RT Rutter MJ | 2004 | Int J Pediatr Otorhinolaryngol2004，68，1： | 1 |
| 9 | Effect of low temperature tempering prior cryogenic treatment on carburized steels显示文摘 | Preciado M Bravo P M Alegre J M | 2006 | Journal of Materials Processing Technology2006，176，13： | 1 |
| 10 | Intrapartum management of severe fetal airway obstruction 显示文摘 | Preciado DA Rutter M J Greenberg JM | 2004 | J Otolaryngol2004，33，： | 1 |
| 11 | Physician advice for smoking cessation显示文摘 | Stead LF Buitrago D Preciado N | 2013 | Cochrane Database Syst Rev2013，43，5： | 1 |
| 12 | Epstein-Barr virus in breast carcinoma in Argentina显示文摘 | Preciado M V Chabay P A De Matteo E N | 2005 | Arch Pathol Lab Med2005，129，3： | 1 |
| 13 | Cryolipolysis for noninvasive fat cell destruction: initial results from a pig model显示文摘 | Zelickson B Egbert BM Preciado J | 2009 | Dermatol Surg2009，35，10： | 1 |
| 14 | A simple microscale meth- od for determining the relative stereoehemistry of sta- tine units显示文摘 | Preciado A Williams P G | 2008 | J Org Chem2008，73，： | 1 |
| 15 | Hernia at 5-mm laparoscopic port site presenting as early postoperative small bowel obstruction 显示文摘 | Reardon PR Preciado A Scarborough T | 1999 | J Laparoendosc Adv Surg Tech A1999，9，6： | 1 |
| 16 | Laryngeal and tracheal stents in children 显示文摘 | Preciado D Zalzal G | 2008 | Curr Opin Otolaryngol Head Neck Surg2008，16，1： | 1 |
| 17 | A diagnostic paradigm for childhood idiopathic sensorineural hearing loss显示文摘 | Preciado DA Lim LH Cohen AP | 2004 | Otolaryngol Head Neck Surg2004，131，： | 1 |
| 18 | Differences in impact of patient and prosthetic characteristics on oral health-related quality oflife among implant-retained overdenture wearers显示文摘 | Preciado A Del Río J Suárez-García MJ | 2012 | J Dent2012，40，10： | 1 |
| 19 | Epstein–Barr virus (EBV) association and latency profile in pediatric Burkitt’s lymphoma: Experience of a single institution in Argentina显示文摘 | Julia Lara Melina Cohen Elena De Matteo Luis Aversa Maria Victoria Preciado Paola Chabay | 2014 | Virol2014，，5： | 1 |
| 20 | Aggressive bronchoscopic man- agement of plastic bronchitis 显示文摘 | Preciado D Verghese S Choi S | 2010 | Int J Pediatr Otorhinolaryn- go12010，74，7： | 1 |
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