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| 1 | Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome显示文摘BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS women.Research has shown that hyperinsulinemia is correlated with increased bone mass.Given that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a result.Subsequently,increased bone mass could be measured using the wrist circumference method.AIM To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with PCOS.METHODS Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were evaluated.The nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and weight.Calculated measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat analyzer.RESULTS The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16.3 cm was found to be the best predictor of IR in Congolese women with PCOS.CONCLUSION Non-dominant wrist circumference is,to date,the best anthropometrical marker of IR in Sub-Saharan African women with PCOS.It could be suggested as an easy-to-detect marker for assessing IR. | Chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli | 2020 | World Journal of Diabetes2020，11，2： | 8 |
| 2 | Peripheral white blood cell count in cerebral infraction显示文摘 | Pozzilli C Dipiero V Pantano P | 1985 | Acta Neurol Scand1985，71，2： | 1 |
| 3 | the Nieotinamide Trialists: meta-analysis of nicotinamide treatment in patients with recent onse insulin dependent diabetes 显示文摘 | Pozzilli P Browne PD Kolb H | 1996 | Diabetes Care1996，19，： | 1 |
| 4 | Beta-cell protection and therapy for latent autoimmune diabetes in adults 显示文摘 | CERNEA S BUZZETrI R POZZILLI P | 2009 | Diabetes Care2009，32，2： | 1 |
| 5 | A new expression of diabetes: double diabetes显示文摘 | Paolo Pozzilli Raffaella Buzzetti | 2006 | Trends in Endocrinology & Metabolism2006，，2： | 1 |
| 6 | Cytokines in sera form insulin dependent diabetic patients at diagosis显示文摘 | Gavallo MG Pozzilli P Bird C | 1991 | Clin Exp Immunol1991，46，： | 1 |
| 7 | Immunomodulation for the prevention of SPIDDM and LADA显示文摘 | POZZILLI P C | 2006 | Ann N Y Acad Sci2006，，1079： | 1 |
| 8 | Advances in the management of multiple sclerosis spasticity: experiences from recent studies and everyday clinical practice 显示文摘 | Pozzilli C | 2013 | Expert Rev Neurother2013，13，12： | 1 |
| 9 | An introduction to new advances in diahe- tes显示文摘 | Leslie RD Pozzilli P | 2002 | Diabetes Metab ResRev2002，18，1： | 1 |
| 10 | Endothelial progenitor cells and their potential therapeutic applications显示文摘 | Khoo CP Pozzilli P Alison MR | 2008 | Regen Med2008，3，6： | 1 |
| 11 | Natalizumab in pediatric multiple sclerosis: results of a cohort of 55 cases 显示文摘 | GHEZZI A POZZILLI C GRIMALDI L M | 2013 | Mult Seler2013，19，8： | 1 |
| 12 | A new subslrain of the non-obese diabetic mouse which develops cataracts ( NOD/Ba/Lopl9 ) 显示文摘 | Mansfield K J Wilson JE pozzilli P Beales PE | 1999 | Br J Ophtbxdmol1999，83，6： | 1 |
| 13 | Endothelial progenitor cells and their potential therapeutic applications显示文摘 | Khoo CP Pozzilli P Alison MR | | 0，，06： | 1 |
| 14 | Autoimmune diabetes not requiring insulin at diagnosis( latent autoimmune diabetes of the adult) 显示文摘 | Pozzilli P Di Mario U | 2001 | Diabetes Care2001，24，8： | 1 |
| 15 | Final analysis of the European multicenter trial on IFN beta-1b in secondary-progressive MS显示文摘 | POLMAN C POZZILLI C | 2001 | Neurology2001，57，11： | 1 |
| 16 | Thiazolidinediones for the prevention of diabetesin the non-obses diabetie (NOD) mouse implications for human type 1 diabetes显示文摘 | Beales PE Pozzilli P | | 0，，2： | 1 |
| 17 | Autoimmune diabetes not requiring insulin at diagnosis(latent autoimmune diabetes of the adult):definition,characterization,and potential prevention显示文摘 | Pozzilli P Di Mario U | | 0，，08： | 1 |
| 18 | Autoimmune diabetes not requiring insulin at diagnosis(latent autoimmune diabetes of the adult) : definition, characterization, and potential prevention显示文摘 | Pozzilli P U.Di Mario | | 0，，08： | 1 |
| 19 | Review of clinical trials:update on oral insulin spray formulation显示文摘 | POZZILLI P RASKIN P PARKIN C G | 2010 | Diabetes Obes Metab2010，12，2： | 1 |
| 20 | Autoimmune diabetes not requiring insulin at diagnosis (Latent autoimmune diabetes of the adult) , Definition , characterization,and potential prevention显示文摘 | Pozzilli P Di Mariou | 2001 | Diabetes Care2001，24，： | 1 |
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