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| 1 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 2 | Pulmonary hypertension in hereditary haemorrhagic telangiectasia显示文摘Hereditary haemorrhagic telangiectasia(HHT) is an autosomal dominant inherited disorder characterised by vascular malformations in predominantly the brain,liverand lungs.Pulmonary hypertension(PH) is increasingly recognised as a severe complication of HHT.PH may be categorised into two distinct types in patients with HHT.Post-capillary PH most often results from a high pulmonary blood flow that accompanies the high cardiac output state associated with liver arteriovenous malformations.Less frequently,the HHT-related gene mutations in ENG or ACVRL1 appear to predispose patients with HHT to develop pre-capillary pulmonary arterial hypertension.Differentiation between both forms of PH by right heart catheterisation is essential,since both entities are associated with severe morbidity and mortality with different treatment options.Therefore all HHT patients should be referred to an HHT centre. | Veronique MM Vorselaars Sebastiaan Velthuis Repke J Snijder Jan Albert Vos Johannes J Mager Martijn C Post | 2015 | World Journal of Cardiology2015，7，5： | 4 |
| 3 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 4 | Weight-bearing activity during youth is a more important factor for peak bone mass than calcium intake显示文摘 | Welten D C Kemper H C Post G B | 1994 | J Bone Miner Res1994，9，7： | 1 |
| 5 | Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase显示文摘 | Moon K D Post C B Durden D L | 2005 | J Biol Chem2005，280，2： | 1 |
| 6 | Molecular analysis of bacterial pathogens in otitis media with effusion显示文摘 | POST J C PRESTON R A JEROME J A | 1995 | JAMA1995，273，： | 1 |
| 7 | Formation of 2-Acetyl-l-pyrroline by Several Bacillus cereus Strains Isolated from Cocoa Fer- mentation Boxes显示文摘 | Romanczyk L J McClelland C A Post L S | 1995 | Journal of agricultural and food chemistry1995，43，2： | 1 |
| 8 | Pathophysiology,diagnosis and prognostic implications of endothelial dysfunction显示文摘 | Munzel T Sinning C Post F | 2008 | Ann Med2008，40，3： | 1 |
| 9 | Fozest soil carbon inventories and dynamics along an elevation gradient in the southern Appalachian Mountains 显示文摘 | Garten C T Post W M Hanson P J | 1999 | Biogeochemistry1999，45，2： | 1 |
| 10 | Montoring and verifying changes of organic carbon in vsoil显示文摘 | Post W M Izaurralde R C Mann L K | 2001 | ClimaticChange2001，51，： | 1 |
| 11 | Analysis of adult otitis media:polymerase chain reaction versus culture for bacteria and viruses显示文摘 | LIEDERMAN E M POST J C AUL J J | 1998 | Ann Otol Rhinol Laryngol1998，107，： | 1 |
| 12 | Soil carbon sequestration and land-use change: processes and potential 显示文摘 | POST W M KWON K C | 2000 | Global Change Biology2000，6，3： | 1 |
| 13 | Impact of tonsillectomy and adenoidectomy on child behavior显示文摘 | Goldstein NA Post C Rosenfeld RM | 2000 | Arch Otolaryngol Head Neck Surg2000，126，： | 1 |
| 14 | Soil carbon sequestration and land use change 显示文摘 | Post W M Kwon K C | 2000 | Global Change Biology2000，6，： | 1 |
| 15 | Changes in quality-of-life after pacemaker implantation: responsiveness of the Aquarel questionnaire 显示文摘 | STOFMEEL M A POST M W KELDER J C | 2001 | Pacing Clin Electrophysiol2001，24，3： | 1 |
| 16 | Soil carbon sequestration and land-use change: processes and potential显示文摘 | Post W M Kwon K C | 2000 | Global Chang Bioology2000，6，： | 1 |
| 17 | Notch/Delta expression in the developing mouse lung显示文摘 | Post L C Ternet M Hogan B L | 2000 | Mech Dev2000，98，12： | 1 |
| 18 | Soil carbon sequestration and landuse change: processes and potential 显示文摘 | Post W M Kwon K C | 2000 | Global Change Biol2000，6，： | 1 |
| 19 | Passing the Baton 显示文摘 | Post R C | 1995 | Technology and Culture1995，36，4： | 1 |
| 20 | Molecular diversity among marine picophytoplankton as revealed by psbA analyses 显示文摘 | Zeidner G Preston C M Delong E F Massana R Post A F Scanlan D L B6ja O | 2003 | Environ Microbio2003，，5： | 1 |
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