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| 1 | Combined locoregional treatment of patients withhepatocellular carcinoma: state of the art显示文摘In recent years, a combination of intervention therapies has been widely applied in the treatment of hepatocellular carcinoma(HCC). One such combined strategy is based on the combination of the percutaneous approach, such as radiofrequency ablation(RFA), and the intra-arterial locoregional approach, such as trans-arterial chemoembolization(TACE). Several types of evidence have supported the feasibility and benefit of combined therapy, despite some studies reporting conflicting results and outcomes. The aim of this review was to explain the technical aspects of different combined treatments and to comprehensively analyze and compare the clinical efficacy and safety of this combined treatment option and monotherapy, either as TACE or RFA alone, in order to provide clinicians with an unbiased opinion and valuable information. Based on a literature review and our experience, combined treatment seems to be a safe and effective option in the treatment of patients with early/intermediate HCC when surgical resection is not feasible; furthermore, this approach provides better results than RFA and TACE alone for the treatment of large HCC, defined as those exceeding 3 cm in size. It can also expand the indication for RFA to previously contraindicated 'complex cases', with increased risk of thermal ablation related complications due to tumor location, or to 'complex patients' with high bleeding risk. | Roberto Iezzi Maurizio Pompili Alessandro Posa Giuseppe Coppola Antonio Gasbarrini Lorenzo Bonomo | 2016 | World Journal of Gastroenterology2016，22，6： | 15 |
| 2 | Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions显示文摘Liver cancers are the second most frequent cause of global cancer-related mortality of which 90%are attributable to hepatocellular carcinoma(HCC).Despite the advent of screening programmes for patients with known risk factors,a substantial number of patients are ineligible for curative surgery at presentation with limited outcomes achievable with systemic chemotherapy/external radiotherapy.This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization,radiofrequency/microwave ablation and more recently selective internal radiation therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant.The authors aim to provide a comprehensive overview of these various image guided minimally invasive therapies with a brief focus on the technical aspects accompanied by a critical analysis of the literature to assess the most up-to-date evidence from comparative systematic reviews and meta-analyses finishing with an assessment of novel combination regimens and future directions of travel. | Riccardo Inchingolo Alessandro Posa Martin Mariappan Stavros Spiliopoulos | 2019 | World Journal of Gastroenterology2019，25，32： | 14 |
| 3 | Transjugular intrahepatic portosystemic shunt for Budd-Chiari syndrome:A comprehensive review显示文摘Budd-Chiari syndrome(BCS)is a relatively rare clinical condition with a wide range of symptomatology,caused by the obstruction of the hepatic venous outflow.If left untreated,it has got an high mortality rate.Its management is based on a step-wise approach,depending on the clinical presentation,and includes different treatment from anticoagulation therapy up to Interventional Radiology techniques,such as transjugular intrahepatic portosystemic shunt(TIPS).TIPS is today considered a safe and highly effective treatment and should be recommended for BCS patients,including those awaiting orthotopic liver transplantation.In this review the pathophysiology,diagnosis and treatment options of BCS are presented,with a special focus on published data regarding the techniques and outcomes of TIPS for the treatment of BCS.Moreover,unresolved issues and future research will be discussed. | Riccardo Inchingolo Alessandro Posa Martin Mariappan Tiago Kojun Tibana Thiago Franchi Nunes Stavros Spiliopoulos Elias Brountzos | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 4 | Characteristic behavior and order relations for indicator variograms 显示文摘 | Journel A G Posa D | 1990 | Mathematical Geology1990，22，： | 1 |
| 5 | Estimating and modeling space-time correlation structures显示文摘 | De Cesare L Myers D E Posa D | 2001 | Statistics &Probability Letters2001，51，1： | 1 |
| 6 | Regulated nucleo/ cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPOI显示文摘 | Ferrigno P Posas F Koepp D | 1998 | EMBO J1998，17，19： | 1 |
| 7 | Optimization of drug eluting balloon use for safety and efficacy: evaluation of the 2nd generation paclitaxel-eluting DIOR-halloon in porcine coronary arteries显示文摘 | Posa A Nyolezas N Hemetsberger R | 2010 | Catheter Cardiovasc Interv2010，76，3： | 1 |
| 8 | Soil moisture retrieval from remotely sensed data: Neural network approach versus Bayesian method显示文摘 | Notarnicola C Angiulli M Posa F | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，2： | 1 |
| 9 | Signal transduction by MAP kinase cascades in budding yeast显示文摘 | Posas F Takekawa M Saito H | 1998 | Curr Opin Microbiol1998，1，2： | 1 |
| 10 | Lung involvement in systemic scle- rosis显示文摘 | Posa M Stelle M Lador F | 2015 | Rev Med Suisse2015，811，469： | 1 |
| 11 | Signal transduction by MAP kinase cascades in budding yeast 显示文摘 | Posas F Takekawa M Saito H | 1998 | Curr Opin Microbiol1998，1，2： | 1 |
| 12 | Use of radar and optical remotely sensed data for soil moisture retrieval over vegetated areas显示文摘 | Notarnicola C Angiulli M Posa F | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，4： | 1 |
| 13 | Functional relationship be- tween cationic amino acid transporters and beta-defensins: implications for dry skin diseases and the dry eye显示文摘 | Jiger K Garreis F Posa A | 2010 | Ann Anat2010，192，2： | 1 |
| 14 | Yeast HOG1 MAP kinase cascade is regulated by a mulfistep phosphorelay mecha- nism in the SLN1-YPD1-SSKI ' two-component' osmosensor显示文摘 | POSAS F WURGLER-MURPHY S M MAEDA T | 1996 | Cell1996，86，6： | 1 |
| 15 | Activation of the yeast SSK2 MAP kinase ki- nase kinase by the SSK1 two-component response regulator 显示文摘 | Posas F Saito H | 1998 | EMBO J1998，17，5： | 1 |
| 16 | Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Shol-dependent activation of the Hog1 MAPK pathway显示文摘 | Raitt DC Posas F Saito H | 2000 | EMBO J2000，19，17： | 1 |
| 17 | The yeast halotolerance determinant HAL3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase显示文摘 | De Nadal E Clotet J Posas F | | 0，，： | 1 |
| 18 | Physico-chemical properties of bilesalt-Tween 80 mixed micelles in the viewpoint of regular solutiontheory 显示文摘 | Posa M Cirin D Krstonosic V | 2013 | Chemical Engineering Science2013，98，29： | 1 |
| 19 | The transcriptional response of yeast to saline stress显示文摘 | Posas F Chambers J R Heyman J A | 2000 | J Biol Chem2000，275，17： | 1 |
| 20 | Requirement of STE50 for osmo- stress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway显示文摘 | Posas F Witten EA Saito H | 1998 | Mol Cell Biol1998，18，10： | 1 |
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