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| 1 | Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity显示文摘Background: Animal models of diet-induced obesity(DIO) are commonly used in medical research for mimicking human diseases. There is no universal animal model, and careful evaluation of variety of factors needs to be considered when designing new experiments. Here, we investigated the effect of 9 weeks high-fat diet(HFD) intervention, providing 60% energy from fat, on parameters of inflammation and insulin resistance in male C57 BL/6 J mice.Methods: Six weeks old mice were initiated on regular diet(RD) or HFD providing 60 kcal energy from fat for 9 weeks. Fasting blood glucose levels were measured by glucometer, and fasting plasma levels of insulin and proinflammatory cytokines by Luminex assay. Insulin sensitivity was evaluated by using QUICKI and HOMA2 indexes.Results: HFD mice showed ~ 40% higher body weight and ~ 20% larger abdominal circumference, due to an increase in the white adipose tissue mass. Liver examination revealed increased size and higher hepatic lipid accumulation in livers from HFD mice compared to their RD counterparts. Animals from the HFD group were characterized with significantly higher presence of crown-like structures(CLS) in WAT and higher plasma levels of proinflammatory cytokines(TNF-α, IL-6, leptin, MCP-1, PAI-1, and resistin). HFD-fed mice also demonstrated impaired insulin sensitivity(lower QUICKI, higher HOMA-insulin resistance(HOMA-IR), and lower HOMA-percent sensitivity(HOMA-%S)) index values.Conclusion: Male C57 BL/6 J mice on 9 weeks HFD providing 60 kcal energy from fat display impaired insulin sensitivity and chronic inflammation, thus making this DIO mouse model appropriate for studies of early stages of obesity-related pathology. | Dimiter Avtanski Valentin A.Pavlov Kevin J.Tracey Leonid Poretsky | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 2 | Hyperinsul inemia and human chorionicgonadotropin synergistically promote the growth of ovarian follicular cysts inrats显示文摘 | Poretsky L Clemons J Bogovich K | 1992 | Metabolism1992，41，8： | 1 |
| 3 | Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome显示文摘 | Poretsky L Piper B | 1994 | Obstet Gynecol1994，84，4： | 1 |
| 4 | Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth ofovarian follicular cysts in rats显示文摘 | Poretsky L Clemons J Bog ovichK | 1992 | Metabolism1992，41，8： | 1 |
| 5 | Hyperinsulinenia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats显示文摘 | Poretsky L Clemons J Bogovich K | 1992 | Metabolism1992，41，8： | 1 |
| 6 | The insulin-like growth factor binding protein superfamily显示文摘 | Poretsky L Cataldo NA Rosenwaks Z | 1999 | Endocrine Rev1999，20，4： | 1 |
| 7 | Endocrine effects of oral dehydroepiandrosterone in men with HIV infection:a prospective,randomized,double-blind,placebo-controlled trial显示文摘 | Poretsky L Brillon DJ Ferrando S | 2006 | Metabolism JT2006，55，7： | 1 |
| 8 | The insu- lin-related ovarian regulatory system in health and disease 显示文摘 | Poretsky L Cataldo NA Rosenwaks Z | 1999 | Endocr1999，20，4： | 1 |
| 9 | nalysis of mi-crobial gene transcripts in environmental samples 显示文摘 | Poretsky R S Bano N Buchan A | 2005 | Applied and Environmental Microbiology2005，71，7： | 1 |
| 10 | HyperinsulinemJa and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats显示文摘 | Poretsky L Clemons J Bogovich K | 1992 | Metabolism1992，41，8： | 1 |
| 11 | Hyperinsulinemia and human chorionic gonadotropin syner-gistically promote the growth of ovarian follicular cysts in rats 显示文摘 | PORETSKY L CLEMONS J BOGOVICH K | 1992 | Metabolism1992，41，8： | 1 |
| 12 | Microbialcommunity gene expression within colonies of the diazotro-ph, Trichodesmium, from the southwest pacific ocean显示文摘 | Hewson I Poretsky R S Dyhrman S T | 2009 | The ISME Journal2009，3，： | 1 |
| 13 | Lack of effect of subtherapcutic vitamin D treatment on glycemic and lipid parameters in Type 2 diabetes:A pi|ot prospective randomized trial显示文摘 | Patel P Poretsky L Liao E | 2010 | J Daabetes2010，2，1： | 1 |
| 14 | Analysis of microbial gene transcripts in environmental samples显示文摘 | Poretsky R S Bano N Buchan A | 2005 | Applied and Environmental Microbiology2005，71，7： | 1 |
| 15 | Hyperinsulinemia and human chorinic gonadotropin synergistically promote Effects of rosiglitazone on ovaries of rats with hyperinsulinemiaZHENG Jiang-li,MIAO Heng,JIANG Xiu-qin,LU Yi-bing(Department of Endocrinology,the Second Affiliated Hospital of NJMU,Nanjing 210011,China)the growth of ovarian follicular cysts in rats显示文摘 | Poretsky L Clemons J Boyovich K | 1992 | Metabolism1992，41，： | 1 |
| 16 | Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat显示文摘 | Bogovich K Clemons J Poretsky L | 1999 | Metabolism1999，48，： | 1 |
| 17 | Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats显示文摘 | Poretsky L Clemons J Bogovich K | 1992 | Metabolism1992，41，8： | 1 |
| 18 | Deep-sea archaea fix and share nitrogen in methane-consuming microbial consortia显示文摘 | Dekas A E Poretsky R S Orphan V J | | 0，，5951： | 1 |
| 19 | The insulin-related ovarian regulatory system in health and disease显示文摘 | Poretsky L Cataldo NA Rosenwaks Z | 1999 | Endocr Rev1999，20，： | 1 |
| 20 | 胰岛素的促性腺功能显示文摘本文通过临床观察及实验研究结果有力地阐明了胰岛素本身或与FSH、LH协同具有促性腺的功能。胰岛素对于卵巢细胞的影响可能是通过与卵巢上的胰岛素受体或IGF-1受体结合产生的。它可直接作用于甾体类固醇激素生成酶协同FSH-LH调节FSH及LH受体的数量,或非特异性地增加细胞活力。 | Poretsky L Kalin MF 吴姝 | 1988 | 国际妇产科学杂志1988，34，4： | 1 |
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