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| 1 | Inclusion complexes of cefuroxime axetil with β-cyclodextrin:Physicochemical characterization, molecular modeling and effect of Larginine on complexation显示文摘The inclusion complexes of poorly water-soluble cephalosporin, cefuroxime axetil(CFA), were prepared with β-cyclodextrin(βCD) with or without addition of L-arginine(ARG) to improve its physicochemical properties. We also investigated the effect of ARG on complexation efficiency(CE) of βCD towards CFA in an aqueous medium through phase solubility behaviour according to Higuchi and Connors. Although phase solubility studies showed AL(linear) type of solubility curve in presence and absence of ARG, the CE and association constant(Ks) of βCD towards CFA were significantly promoted in presence of ARG,justifying its use as a ternary component. The solid systems of CFA with βCD were obtained by spray drying technique with or without incorporation of ARG and characterized by differential scanning calorimetry(DSC), X-ray powder diffractometry(XRPD), scanning electron microscopy(SEM), and saturation solubility and dissolution studies. The molecular modeling studies provided a better insight into geometry and inclusion mode of CFA inside βCD cavity. The solubility and dissolution rate of CFA were significantly improved upon complexation with βCD as compared to CFA alone. However, ternary system incorporated with ARG performed better than binary system in physicochemical evaluation. In conclusion, ARG could be exploited as a ternary component to improve the physicochemical properties of CFA via βCD complexation. | Sarika Sapte Yogesh Pore | 2016 | Journal of Pharmaceutical Analysis2016，6，5： | 3 |
| 2 | Magnetic resonance studies of a gas-solids fluidised bed:Jet-jet and jet-wall interactions显示文摘Magnetic resonance imaging(MRI)gave images of air jets from orifices in the distributor plate of a bed of poppy seeds.Attention focused on two features:(1)The interaction between nearby vertical jets from two,three or four orifices;(2)Wall effects,where one or more orifices created vertical jets near the vertical wall of the cylinder containing the particle bed.The results show that nearby jets are mutually attracted.Likewise a jet near a wall bends out of the vertical,towards the wall.For multiple adjacent jets,the jet lengths show dependence on orifice layout:the lengths are in reasonable agreement with published measurements,by other methods,for single jets.The MRI gives three-dimensional images of the single jets and of multiple jets,separate or merging. | Meenal Pore Daniel J.Holland Thusara C.Chandrasekera Christoph R.Müller Andrew J.Sederman John S.Dennis Lynn F.Gladden John F.Davidson | 2010 | Particuology2010，8，6： | 2 |
| 3 | Magnetic resonance studies of jets in a gas-solid fluidised bed显示文摘Magnetic resonance imaging (MRI) has been used to study the behaviour of jets at the distributor of a 50 mm diameter fluidised bed of 0.5 mm diameter poppy seeds. Two perforated-plate distributors were examined, containing either 10 or 14 holes, each 1 mm diameter. Ultra-fast MR imaging was able to show the transient nature of the upper parts of the jets, where discrete bubbles are formed. Imaging in 3D showed that the central jets were the longest for flow rates below minimum fluidisation. Above minimum fluidisation, the outer jets, nearest the wall of the fluidised bed, arched inward towards the central axis. In this latter case, interpretation of the time-averaged 3D image required the use of ultra-fast MR imaging to identify the approximate height above the distributor at which discrete bubbles were formed. The apparently continuous void extending along the central axis above this height in the time-averaged 3D image was thus identified, using ultra-fast MR imaging, as representing the averaged paths of released bubbles. Time-averaged MR velocity mapping was also used to identify dead zones of stationary particles resting on the distributor between the jets. The dead zones could be observed when the superficial velocity of the gas approached minimum fluidisation, but they were smaller than those observed at lower gas superficial velocity. Comparable images of a single jet through 1.2 mm diameter poppy seeds from MRI and electrical capacitance volume tomography (ECVT) are also demonstrated. | Meenal Pore Thusara C. Chandrasekera Daniel J. Holland Aining Wang Fei Wang Qussai Marashdeh Michael D. Mantle Andrew J. Sederman Liang-Shih Fan Lynn F. Gladden John S. Dennis | 2012 | Particuology2012，10，2： | 2 |
| 4 | Epidermal growth factor receptor inhibition modulates the micro- environment by vascular normalization to improve chemotherapy and radiotherapy efficacy 显示文摘 | Cerniglia GJ Pore N Tsai JH | 2009 | PLoS One2009，4，8： | 1 |
| 5 | GI lesions in Henoch-Sehonlein purpura 显示文摘 | Pore G | 2002 | Gastrointest Endosc2002，55，2： | 1 |
| 6 | Application of Dempster-Shafer Theory in Condition Monitoring Applications: A Case Study 显示文摘 | Parikh C R Pore M J Jones N B | 2001 | Pattern Recognition Letter2001，，22： | 1 |
| 7 | Design and synthesis of flu- conazole-bile acid conjugate using cick reaction显示文摘 | Pore VS Aher NG Kumar M | 2006 | Tetrahedron2006，62，11： | 1 |
| 8 | Spl is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism显示文摘 | Pore N Liu S Shu F K | 2004 | Mol Biol Cell2004，15，11： | 1 |
| 9 | Wholeplant carbon relations and root respiration associated with root tolerance to high soil temperature for Agrostis grasses显示文摘 | Lyons Eric M Pore John DaCosta Michelle Huang Bingru | 2007 | Environmental and Experimental Botany2007，59，： | 1 |
| 10 | formation: an ancient yet complex form of attack 显示文摘 | lacovache 1 Goot F G and Pemo! L Pore | 2008 | Bioehimieaet Biophys''ira Acta - Biomem- branes2008，1778，78： | 1 |
| 11 | 查看详情显示文摘 | Poree D.E Giles M.D Lawson L.B He J. Grayson S.M | | 0，，： | 1 |
| 12 | Up -regulation of type I1 colla- gen gene by 17beta- estradiol in articular chondroeytes involves Spl/3, Sox - 9, and estrogen receptor alpha显示文摘 | Maneix L Servent A Poree B | 2014 | J Mol Med ( Bed)2014，92，11： | 1 |
| 13 | Regulation of glutl mRNA by HIF: interaction between H-ras and hypoxia 显示文摘 | Chen C Pore N Behrooz A et cd | 2000 | J Biol Chem2000，276，12： | 1 |
| 14 | Antibiotic susceptibility testing by flow cytometry显示文摘 | Pore RS | 1994 | J Antimicrob Chemother1994，34，5： | 1 |
| 15 | Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3 '-kinase and distinct from that induced by hypoxia显示文摘 | Pore N Lee J | 2000 | Cancer Res2000，60，20： | 1 |
| 16 | GI lesions in Henoch Sehonlein purpura显示文摘 | Pore G | 2002 | Gastrointest Endosc2002，55，2： | 1 |
| 17 | Epidermal growth factor receptor trans-criptionally up-regulates Vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinosital 3'-kinase and distinet from that induced by hypoxia显示文摘 | Maity A Pore N Lee J | 2000 | Cancer Res2000，60，20： | 1 |
| 18 | Steroidal conjugates and their pharmacological applications显示文摘 | Salunke DB Hazra B G Pore V S | 2006 | Curr Med Chem2006，13，： | 1 |
| 19 | Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor显示文摘 | Hiltermann TJ Pore MM van den Berg A | 2012 | Ann Oncol2012，23，11： | 1 |
| 20 | Nelfinavir down regulates hypoxia-inducible faclor 1 alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy 显示文摘 | Pore N Gupta AK Cerniglia GJ | 2006 | Cancer Res2006，66，18： | 1 |
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