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| 1 | 2017年哮喘研究进展:发病机制、生物制剂和遗传学显示文摘总结了近年来部分关于哮喘最重要的研究进展。首先,关注哮喘发展和加重机制的新发现,随后讨论了新的潜在的哮喘生物标志物,包括射线性标记物的使用。第二,过去一年里临床医师已经开始使用几种治疗哮喘的新型生物制剂,总结这些药物的应用进展及其对哮喘临床治疗的影响。第三,探讨了哮喘遗传学的重要发现和哮喘表型的异质性,如同环境因素一样,这些因素在哮喘的发展和急性发作过程中也发挥着重要的作用。最后,讨论了医学知识的进步以及它们将如何影响哮喘的防治。 | Mitchell H. Grayson Scott Feldman Benjamin T. Prince Priya J. Patel Elizabeth C. Matsui Andrea J. Apter 杨玲(翻译) 刘婷(翻译) 刘春涛(审校/点评) | 2018 | 中华临床免疫和变态反应杂志2018，12，6： | 13 |
| 2 | Improving mine safety technology and training in the U.S.recommendations of the Mine Safety Technology and Training Commission显示文摘The key issues studied focused on underground coal mining and included (1) prevention of explosions in sealed areas,(2) better emergency preparedness and re- sponse,(3) improvement of miners' ability to escape,(4) better protection of miners before and after a fire or explosion,(5) improved provision of oxygen,and (6) development and implementation of more robust post-incident communication.The U.S.Congress passed the Mine Improvement and New Emergency Response Act of 2006,which mandated new laws to address the issues.Concurrent with investigations and congressional deliberations, the National Mining Association formed the independent Mine Safety Technology and Training Commission to study the state-of-the-art relative to technology and training that could address the vulnerabilities exposed by the mine disasters.As discussed,the report outlined persistent vulnerabilities linked with significant hazards in underground coal mines, and made recommendations to provide a path for addressing them.Overall the commis- sion report made 75 recommendations in the areas of risk-based design and management, communications technology,emergency response and mine rescue procedures,training for preparedness,and escape and protection strategies.In its deliberations,the commis- sion importantly noted that mine safety in the U.S.needs to follow a new paradigm for en- suring mine safety and developing a culture of prevention that supports safe production at the business core.In the commission's viewpoint,the bottom line in protecting coal miners is not only adopting a culture of prevention but also systematically pursuing mitigation of significant risks. | GRAYSON R. Larry | 2008 | Journal of Coal Science & Engineering(China)2008，14，3： | 4 |
| 3 | Bile acids and sphingolipids in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, and insulin resistance. Despite extensive research efforts, there are no pharmacologic or biological therapeutics for the treatment of NAFLD. Bile acids and sphingolipids are well-characterized signaling molecules. Over the last few decades, researchers have uncovered potential mechanisms by which bile acids and sphingolipids regulate hepatic lipid metabolism. Dysregulation of bile acid and sphingolipid metabolism has been linked to steatosis, inflammation, and fibrosis in patients with NAFLD. This clinical observation has been recapitulated in animal models, which are well-accepted by experts in the hepatology field. Recent transcriptomic and lipidomic studies also show that sphingolipids are important players in the pathogenesis of NAFLD. Moreover, the identification of bile acids as activators of sphingolipid-mediated signaling pathways established a novel theory for bile acid and sphingolipid biology. In this review, we summarize the recent advances in the understanding of bile acid and sphingolipid-mediated signaling pathways as potential contributors to NAFLD. A better understanding of the pathologic effects mediated by bile acids and sphingolipids will facilitate the development of new diagnostic and therapeutic strategies for NAFLD. | Kaitlyn G.Jackson Grayson W.Way Huiping Zhou | 2022 | Chinese Medical Journal2022，，10： | 2 |
| 4 | 中枢神经系统PPAR-γ在调节能量平衡中的作用显示文摘过氧化物酶体增殖物激活受体-γ(PPAR-γ)是一种核受体,可被脂质激活,诱导参与脂质和葡萄糖代谢旧关基因的表达,因此它是可将营养成分信号启动代谢程序的中介。PPAR-γ是噻唑烷二酮(TZD)类胰岛素噌敏药物的作用靶点,这种药物广泛用于治疗2型糖尿病。TZDs的一种常见副作用是体重增加。之前, | Ryan KK Li B Grayson BE 李兴 秦旭平 | 2011 | 中南医学科学杂志2011，39，3： | 2 |
| 5 | Potential risk effect from elevated levels of soil heavy metals on human health in the Niger delta显示文摘 | Richard Olawoyin Samuel A. Oyewole Robert L. Grayson | 2012 | Ecotoxicology and Environmental Safety2012，，： | 2 |
| 6 | 多西环素可否替代大环内酯类药物用于治疗社区获得性肺炎显示文摘2007年美国感染病学会制定的社区获得性肺炎(CAP)诊治指南推荐经验性使用呼吸喹诺酮类或8内酰胺类联合大环内酯类药物治疗CAP非ICU住院患者。大环内酯类药物中的阿奇霉素因与其他药物相互作用少,服用方便和安全性高而被广泛使用。但是最近有研究报道阿奇霉素可能增加患者的心血管死亡风险。与未接受抗生素治疗的对照组相比,阿奇霉素治疗5d心血管病患者死亡和全因死亡危害比分别为2.88和1.85。 | Teh B Grayson ML Johnson PD 周芬芬 黄海辉 | 2014 | 中国感染与化疗杂志2014，14，4： | 2 |
| 7 | A short note on the evolution of surfaces via mean curvature显示文摘 | Grayson M | 1989 | J Duke Math1989，58，： | 1 |
| 8 | Convergent dendrons and dendrimers:From synthesis to applications 显示文摘 | Grayson S M Frechet J M | 2001 | J Chem Rev2001，101，： | 1 |
| 9 | Increasing resistance to beta-lactam antibiotics among clinical isolates of Enterococcus faecium: a 22-year review at one institution 显示文摘 | Grayson ML Eliopoulos GM Wennersten CB | 1991 | Antimicrobial Agents and Chemotherapy1991，35，11： | 1 |
| 10 | Pre- ferred states in spatial soil moisture patterns: local and nonlocal controls 显示文摘 | Grayson R B Western A W Chiew F H S | 1997 | Water Resources Research1997，33，12： | 1 |
| 11 | Preoperative columella lengthening in bilateral cleft lip and palate 显示文摘 | Grayson BH Cutting C Wood R | 1993 | Plast Recon- str Surg1993，92，7： | 1 |
| 12 | Timing of intra-aortic balloon pump support and 1-year survival显示文摘 | Ramnarine IR Grayson AD Dihmis WC | | 0，，05： | 1 |
| 13 | Water quality in mountain ash forests - separating the impacts of roads from those of logging operations显示文摘 | Grayson R B Haydon S R Jayasuriya M D A | 1993 | Journal of Hydrology1993，150，2： | 1 |
| 14 | Management strategies forneonatal hypoglycemia 显示文摘 | Sweet CB Grayson S Polak M | 2013 | J Pediatr Pharmacol Ther2013，18，3： | 1 |
| 15 | Hyperuricemia and incident hypertension:a systematic review and meta-analysis显示文摘 | Grayson PC Kim SY La Valley M | 2011 | Arthritis Care Res(Hoboken)2011，63，： | 1 |
| 16 | Effects of Dexmedetomidine on Microregional O2 Balance显示文摘 | Chi OZ Grayson J Barsoum S | 2015 | Journal of Stroke and Cerebrovascular Diseases2015，24，1： | 1 |
| 17 | Presurgical nasoalveolar molding in infants with cleft lip and palate显示文摘 | Grayson BH Santiago PE Brecht LE | 1999 | Cleft Palate Craniofac J1999，36，6： | 1 |
| 18 | Presurgical nasoaveolar molding in infants with cleft lip and palate 显示文摘 | Grayson BH Santiago PE Bretch I | 1999 | Cleft Palate Crainof J1999，36，6： | 1 |
| 19 | Salmon GnRH and its analogues bind the human plancental receptor显示文摘 | Siler K Theresa M Grayson M | 2001 | Journal of the Society for Gynecologic Investigation2001，8，4： | 1 |
| 20 | The human reelin gene:transcription factors(+),repressors(-)and the methylationswitch(+/-)in schizophrenia显示文摘 | Grayson D R Chen Y Costa E | 2006 | Pharmacol Ther2006，111，1： | 1 |
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