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| 1 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 2 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 3 | Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency:a Clinical Multidetector Computed Tomography Study显示文摘Objective To investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. Methods Orchiectomized and ovariectomized rat models are used to investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. A rat vertebral body can be longitudinally divided into central portion, which contain more trabecular bone, and para-endplate portions which contain more compact bone. In matured male and female Wistar and Sprague-Dawley rat lumbar spines, we investigated baseline bone mineral density (BMD) characteristics and the differential segmental responses in bone loss within the lumbar vertebral body post gonadal surgery with clinical multidetector computed tomography. Results Para-endplate sections had a higher BMD than central sections. The cephalad para-endplate sections had a higher BMD than the caudad para-endplate sections. Eight weeks after gonadal removal, there was more bone loss in central sections than para-endplate sections. The relative difference of bone loss between para-endplate and central sections was more apparent in male rats than in female rats. There was more bone loss in caudad sections than cephalad sections; this lead to a further increase of BMD difference between caudad para-endplate sections and cephalad para-endplate sections post gonadal surgery. Conclusion The approach described in this study provided a consistent way to study BMD change within predominantly compact bone portion and trabecular bone portion of the vertebral body. | DENG Min WANG Yi Xiang James F. GRIFFITH LU Gang Anil T AHUJA POON Wai S | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 4 | Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma ( EPOIHCC )显示文摘 | Joong‐Won Park Deepak Amarapurkar Yee Chao Pei‐Jer Chen Jean‐Francois H. Geschwind Khean Lee Goh Kwang‐Hyub Han Masatoshi Kudo Han Chu Lee Rheun‐Chuan Lee Laurentius A. Lesmana Ho Yeong Lim Seung Woon Paik Ronnie T Poon Chee‐Kiat Tan Tawesak Tanwandee Gao | 2013 | Liver Int2013，，3： | 2 |
| 5 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peris J S M Lai S T Poon L L M | 2003 | Lancet2003，361，： | 2 |
| 6 | Coronavirus as a possible cause of severe respiratory syndrome显示文摘 | PERIS J S M LAI S T POON L L M | 2003 | Lancet2003，361，9366： | 2 |
| 7 | SARS study group:coro-navirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris J S Lai S T Poon L L | 2003 | Lancet2003，361，： | 2 |
| 8 | Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes 显示文摘 | Poon T C Yip T T Chan A T | 2003 | Clin Chem2003，49，5： | 1 |
| 9 | Antisecretory agents prevention of post-ERCP pancreatitis :rationale for use and clinical results 显示文摘 | Poon R T Fan S T | 2003 | JOP2003，4，1： | 1 |
| 10 | Provision of continuous VCR functions in interactive broadcast VoD systems 显示文摘 | POON W F LOK T FENG J | 2005 | IEEE Transition Broadcasting2005，51，4： | 1 |
| 11 | The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma 显示文摘 | CHI-MAN TANG T TUNG-PING POON R FAN ST | 2005 | Biomed Pharmacother2005，59，2： | 1 |
| 12 | Adaptive Batching Scheme for Multicast Video-on-demand Systems显示文摘 | POON W E LO K T FENG J | 2001 | IEEE Transactions on Broadcasting2001，47，1： | 1 |
| 13 | Coronavirus as a possible cause of severe acute respiratory syndrome 显示文摘 | Peiris J S M Lai S T Poon L L M | 2003 | Lancet2003，361，： | 1 |
| 14 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris LAI S T POON LL | | 0，，： | 1 |
| 15 | 2010, Reassort- ment of pandemic H1N1/2009 influenza A virus in swine 显示文摘 | Vijaykrishna D Poon L L Zhu H C Ma S K Li 0 T Che- unq C L Smith G J Peiris J S Guan Y | 2010 | Science2010，328，5985： | 1 |
| 16 | Macrophage migration inhibitory factor: Roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carci- noma显示文摘 | Ren Y Tsui H T Poon R T P | 2003 | Int J Cancer2003，107，1： | 1 |
| 17 | Both antiangiogenesis and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584显示文摘 | Liu Y Poon R T Li Q | 2005 | Cancer Res2005，65，9： | 1 |
| 18 | Serum vascular endothelial growth factor predicts invasion hepatocellular carcinoma:a prospective study显示文摘 | Poon R T Ng I O Lau C | 2001 | Ann Surge2001，233，2： | 1 |
| 19 | Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma 显示文摘 | Poon R T Lau C P Ho J W Yu W C Fan S T Wong J | 2003 | Clin Cancer Res2003，9，： | 1 |
| 20 | Cornovavirus as a possible cause of sever acute respiratory syndrome 显示文摘 | Peiris J S Lai S T Poon L L | 2003 | Lancet2003，361，9366： | 1 |
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