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| 1 | Magnetic Resonance Imaging and Histopathological Analysis of Experimental Muscle Injuries in a Rabbit显示文摘Objective To investigate the correlation of magnetic resonance imaging(MRI) with histopathological changes,and to evaluate T2mapping in assessing muscle trauma in a rabbitmodel of muscle injury.Methods We divided 35 rabbits into seven groups that each represented a different time point after intramuscular hemorrhage and muscle injury.Hemorrhage was created by injecting autologous blood into the left legs,and muscle injury was created by scalpel incision of the biceps femoris of the right legs.At different time points,the rabbits underwent T1-weighted imaging and T2-weighted imaging(T1WI and T2WI) and T2mapping.T2relaxation times were measured,and the corresponding samples were evaluated for pathological changes.Results After 2 h,the intramuscular hemorrhage model demonstrated an increased signal intensity on both T1WI and T2WI.Histological examination showed erythrocytes within the muscle bundle.On days 1and 3,the MRI signals were decreased,and there were no significant changes after day 7.From 2 h to 3days,the muscle-injury model showed a high signal on both T1WI and T2WI.Corresponding pathological changes included rupture and edema of muscle fibers,and inflammation.The abnormal signals were reduced on day 7.After day 14,the T2WI intensity remained high.T1WI showed no abnormal changes,but some models showed a high signal,representing fresh bleeding and fatty tissue.T2relaxation times were significantly different between the central and marginal regions,and between the marginal and normal regions.Conclusion MRI clearly demonstrates intramuscular hemorrhage and muscle injury,which correlate well with histopathological changes.T2mapping is useful in assessing the extent of injury. | YAN Dong ZHANG Jing LIANG Wei SUN Jing LIU Bao Yue TIAN Wei CHENG Xiao Guang | 2013 | Biomedical and Environmental Sciences2013，26，10： | 7 |
| 2 | 性别对腰椎退行性滑脱发病机制及手术治疗的影响显示文摘近年来,性别的差异引起了各专业的广泛兴趣。尽管有些因素可以用性别之间的生物学差异来解释,但性别差异对腰椎退行性滑脱的发病机制及手术治疗的影响仍存在许多争议。目前人们对于腰椎退行性滑脱的流行病学已经进行了大量研究并有了初步认识。已有大量研究表明女性腰椎退行性滑脱发生率较男性高,提示性别差异与腰椎退行性滑脱有密切联系。本文通过回顾以往文章,总结女性病人腰椎退行性滑脱可能的独立发生机制,探讨腰椎退行性滑脱的发生率和风险因素在性别方面的差异,分析性别差异对腰椎退行性滑脱病人的手术治疗和预后的影响,以期为临床上预防和治疗女性腰椎退行性滑脱提供相应的理论指导。 | 姜峰 王运涛 吴小涛 刘国臻 徐玉柱 | 2020 | 骨科2020，11，6： | 1 |
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