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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | On-site sorting of construction and demolition waste in Hong Kong 显示文摘 | Poon CS Ann TW Yu Ng LH | 2001 | Resources Conservation and Recycling2001，32，1： | 1 |
| 3 | Viral load of HPV in esophageal squamous cell carcinoma显示文摘 | Si HX Tsao SW Poon CS | 2003 | Int J Cancer2003，103，4： | 1 |
| 4 | Evidence for a direct action of melatonin on the immune system显示文摘 | Poon AM Liu ZM Pang CS | 1994 | Biol Signal1994，3，2： | 1 |
| 5 | Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays 显示文摘 | Poon LL Chan KH Smith GJ Leung CS Guan Y Yuen KY Peiris JS | 2009 | Clin Chem2009，55，8： | 1 |
| 6 | Allelic loss on chromosome 1 is associated with tumor progression of cervical carcinoma显示文摘 | Chung TK Poon CS | 1999 | Cancer1999，86，7： | 1 |
| 7 | Heavy metal contamination of urban soils and street dusts in Hong Kong显示文摘 | Li XD Poon CS Liu PS | | 0，，： | 1 |
| 8 | Radiologic diagnosis of cerebral venous thrombosis: pictorial review 显示文摘 | Poon CS Chang JK Swarnkar A | 2007 | MR Am J Roentgenol2007，189，6： | 1 |
| 9 | Effect of bar - code technology on the safety of medication administration 显示文摘 | Poon EG Keohane CA Yoon CS etal | 2010 | The New England Journal of Medi- cine2010，362，18： | 1 |
| 10 | Effect of bar-code technology on the safety of medication administration显示文摘 | Poon EG Keohane CA Yoon CS | | 0，，18： | 1 |
| 11 | Digital subtraction CT angiography for detection of intracranial aneurysms:comparison with three-dimensional digital subtraction angiography显示文摘 | Lu L Zhang LJ Poon CS | 2012 | Radiology2012，262，2： | 1 |
| 12 | Digital subtraction CT angi-ography for detection of intracranial aneurysms : comparison withthree - dimensional digital subtraction angiography 显示文摘 | LU L ZHANG U POON CS | 2012 | Radiolo-gy2012，262，2： | 1 |
| 13 | Rapid detection of the severe acute respiratory syndrome (SARS) coronavirus by a loop-mediated isothermal amplification assay显示文摘 | Poon LL Leung CS Tashiro M | 2004 | Clin Chem2004，50，6： | 1 |
| 14 | Detection of nonlinear dynamics in short,noisy time series显示文摘 | Barahona M Poon CS | 1996 | Nature1996，381，： | 1 |
| 15 | Indoor air quality investigation on commercial aircraft显示文摘 | Lee SC Poon CS Li XD | | 0，，： | 1 |
| 16 | Digital subtraction CT angiography for detection of intracranial aneurysms: comparison with three- dimensional digital subtraction angiography 显示文摘 | Lu L Zhang LI Poon CS | 2012 | Radiology2012，262，2： | 1 |
| 17 | Enzymatic determination of total serum cholesterol 显示文摘 | Allain CC Poon LS Chan CS | 1974 | Clin Chem1974，20，： | 1 |
| 18 | Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma显示文摘 | Poon RT Ho JW Tong CS | | 0，，10： | 1 |
| 19 | Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading 显示文摘 | Poon CS Tin C | 2013 | Respir Physiol Neurobiol2013，186，14： | 1 |
| 20 | Influence of Moisture States of Natural and Recycled Aggregates on the Slump and Compressive Strength of Concrete显示文摘 | Poon CS Shui ZH Lam L | 2004 | Cement and Concrete Research2004，，34： | 1 |
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