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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 3 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 4 | Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function:implications for a strategy of salvage transplantation显示文摘 | Poon RT Fan ST Lo CM Liu CL Wong J | | 0，，03： | 1 |
| 5 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis显示文摘 | Chen DW Tung-Ping Poon R Liu CL | 2004 | Surgery2004，135，4： | 1 |
| 6 | A randomized placebocontrolled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma显示文摘 | Yuen MF Poon RT Lai CL | | 0，，： | 1 |
| 7 | A randomized,controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC Lam CM Poon RT Ng IO Fan ST Wong J | | 0，，06： | 1 |
| 8 | Management of gallstone cholangitis in the era of laparoscopic cholecystectomy显示文摘 | Poon RT Liu CL Lo CM | 2001 | Arch Surg2001，136，1： | 1 |
| 9 | Immediate and longterm outcomes of hepatectomy for hepatolithiasis显示文摘 | Chen DW TungPing Poon R Liu CL | 2004 | Surgery2004，135，4： | 1 |
| 10 | Immediate and long-term out-comes of hepatectomy for hepatolithiasis 显示文摘 | Chen DW Poon TP Liu CL | 2004 | Surgery2004，135，4： | 1 |
| 11 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis显示文摘 | Chen DW Poon RT Liu CL | 2004 | Surgery2004，135，8： | 1 |
| 12 | Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection显示文摘 | Hung IF Poon RT Lai CL | 2008 | Am J Gastroenterol2008，103，7： | 1 |
| 13 | Intracerebral hemorrhage models in rat:comparing collagenase to blood infusion 显示文摘 | MacLellan CL Silasi G Poon CC | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 14 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis显示文摘 | Chen DW Tung-Ping Poon R Lui CL | 2004 | Surgery2004，135，4： | 1 |
| 15 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis 显示文摘 | Chen DW Tung-Ping Poon R Liu CL | 2004 | Surgery2004，135，4： | 1 |
| 16 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis 显示文摘 | Chen DW Tung-Ping Poon R Liu CL | 2004 | Surgery2004，135，4： | 1 |
| 17 | Management of gallstone cholangitis in the era of laparoscopic cholecysteetomy 显示文摘 | Poon RT Liu CL Lo CM | 2001 | Arch Surg2001，136，1： | 1 |
| 18 | A randomized placebocontrolled study of long-acting oetreotide for the treatment of advanced hepatocellular carcinoma显示文摘 | Yuen MF Poon RTP Lai CL | 2002 | Hepatology2002，6，3： | 1 |
| 19 | Recurrence of hepatitis B-relatedhepatocellular carcinoma is associated with high viral load at thetime of resection 显示文摘 | Hung IF Poon RT Lai CL | 2008 | Am J Gastroenterol2008，103，7： | 1 |
| 20 | Intracerebral hemorrhagemodels in rat : comparing collagenase to blood infusion显示文摘 | MacLellan CL Silasi G Poon CC | 2008 | J Cereb BloodFlow Metab2008，28，3： | 1 |
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