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| 1 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 2 | Long-term changes in biological soil crust cover and composition显示文摘Introduction:Communities change over time due to disturbances,variations in climate,and species invasions.Biological soil crust communities are important because they contribute to erosion control and nutrient cycling.Crust types may respond differently to changes in environmental conditions:single-celled organisms and bryophytes quickly recover after a disturbance,while lichens are slow growing and dominate favorable sites.Community change in crusts has seldom been assessed using repeated measures.For this study,we hypothesized that changes in crust composition were related to disturbance,topographic position,and invasive vegetation.Methods:We monitored permanent plots in the Columbia Basin in 1999 and 2010 and compared changes in crust composition,cover,richness,and turnover with predictor variables of herbivore exclosure,elevation,heat load index,time since fire,presence of an invasive grass,and change in cover of the invasive grass.Results:Bryophytes were cosmopolitan with high cover.Dominant lichens did not change dramatically.Indicator taxa differed by monitoring year.Bryophyte and total crust cover declined,and there was lower turnover outside of herbivore exclosures.Lichen cover did not change significantly.Plots that burned recently had high turnover.Increase in taxon richness was correlated with presence of an invasive grass in 1999.Change in cover of the invasive grass was positively related to proportional loss and negatively related to gain.Conclusions:Composition and turnover metrics differed significantly over 11 years,though cover was more stable between years.This study can be a baseline for assessing change in crust composition due to anthropogenic influences. | Eva Dettweiler-Robinson Jeanne M Ponzetti Jonathan D Bakker | 2013 | Ecological Processes2013，2，1： | 3 |
| 3 | FMEA: a model for reducing medical er- rors显示文摘 | Chiozza ML Ponzetti C | 2009 | Clin Chim Acta2009，40，1： | 1 |
| 4 | FMEA: a model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 5 | FMEA: A model for reducing medical errors 显示文摘 | Maria Laura Chiozza Clemente Ponzetti | 2009 | Clinica Chimica Acta2009，404，1： | 1 |
| 6 | FMEA: A model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Act2009，404，1： | 1 |
| 7 | Biotic soii crusts of Oregon's shrub steppe:community composition in relation to soil chemistry, climate, and livestock activity 显示文摘 | Ponzetti J M MeCune B P | 2001 | Bryologist2001，104，2： | 1 |
| 8 | Biotic soil crusts of Oregon's shrub steppe: communitycomposition in relation to soil chemistry, climate, and livestock aetivity显示文摘 | Ponzetti J M Mccune B P | 2001 | Bryologist2001，104，2： | 1 |
| 9 | Biotic soil crusts of Oregon's shrub steppe: community composition in relation to soil chemistry, cli- mate, and livestock activity 显示文摘 | Ponzetti JM Mccune BP | 2001 | The Bryologist2001，104，2： | 1 |
| 10 | Biotic soil crusts of Oregons shrub steppe: community composition in relation to soil chemistry, climate, and livestock activity显示文摘 | Ponzetti J M Mccune B P | 2001 | The Bryologist2001，104，2： | 1 |
| 11 | FMEA:a model for reducing medical errors显示文摘 | Chiozza ML Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 12 | Biotic soil crusts of Oregon's shrub steppe:community composition in relation to soil chemistry,climate,and livestock activity显示文摘 | Ponzetti J M Mccune B P | 2001 | Bryologist2001，104，2： | 1 |
| 13 | Biotic soil crusts of Oregon's shrub steppe:community composition in relation to soil chemistry,climate,and livestock activity显示文摘 | Ponzetti J M Mccune B P | 2001 | Bryologist2001，104，2： | 1 |
| 14 | FMEA:A model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 15 | Biotic soil crusts of Oregon's shrub steppe:communitycomposition in relation to soil chemistry,climate,and livestockactivity显示文摘 | Ponzetti J M Mccune B P | 2001 | Bryologist2001，104，2： | 1 |
| 16 | FMEA:a model for reducing medical errors显示文摘 | Choozza M L Ponzetti C | 2009 | Clin Chem Acta2009，404，1： | 1 |
| 17 | FMEA: A model for reducing medical errors显示文摘 | Maria Laura Chiozza Clemente Ponzetti | 2009 | Clinica Chimica Acta2009，，1： | 1 |
| 18 | Biotic soil crusts of Oregon's shrub steppe:communitycomposition in relation to soil chemistry,climate,and livestockactivity显示文摘 | Ponzetti J M Mccune B P | 2001 | Bryologist2001，104，2： | 1 |
| 19 | Biotic soil crusts of Oregon's shrub steppe: Community composition in relation to soil chemistry, climate, and livestock activity显示文摘 | Ponzetti J M McCune B P | 2001 | The Bry- ologist2001，104，2： | 1 |
| 20 | Marriage as Covenant:Tradition as a Guide to Marriage Education in the Pastoral Context显示文摘 | James J Ponzetti Jr Barbara H | | 0，，03： | 1 |
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