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| 1 | Is there a place for optimizing thoracic radiotherapy in limited-stage small cell lung cancer after twenty years?显示文摘Thoracic radiotherapy(TRT)is one of the main treatments in limited-stage small cell lung cancer(LS-SCLC).Hyperfractionated TRT(45 Gy,1.5 Gy twice daily)has been the standard of care(SOC)since Turrisi and colleagues published the results of their clinical trial in 1999.Two meta-analyses have demonstrated the benefits of concurrent chemotherapy and TRT in terms of intrathoracic disease control at 2 years and 3-year overall survival(OS).The phase 2 trial by Grønberg et al(2016)comparing once-daily hypofractionated TRT to twice-daily hyperfractionated TRT in LS-SCLC found similar outcomes in both groups in terms of response rate,progression-free survival(PFS),grade 3-4 adverse effects,and OS.The CONVERT trial,published in 2017,failed to demonstrate the superiority of the conventional scheme(once-daily TRT)vs twice-daily radiotherapy,despite the application of modern radiotherapy techniques and a quality assurance programme,thus confirming the twice-daily hyperfractionated regimen as the SOC.At the 2020 American Society of Clinical Oncology(ASCO)annual meeting,Grønberg et al reported preliminary findings from a phase 2 trial comparing two different TRT dose regimens(45 Gy vs 60 Gy),both administered twice daily.Those data demonstrated a marked improvement in 2-year survival rates in the high dose arm(70.2%vs 46.1%,P=0.002),despite similar objective response rates and PFS outcomes.Those findings provide a new treatment alternative to consider:Hyperfractionated,high-dose TRT.However,the results of that trial will need to be validated in a large,randomized phase 3 study.The results of the phase 2 CALCG 30610 trial will help to clarify the optimal dose and regimen.The potential role of upfront immunotherapy,which early data suggest may improve OS,also needs to be determined. | Jose Maximo Barros Manglio Miguel Rizzo Jorge Oscar Chiozza Felipe Counago | 2021 | World Journal of Clinical Oncology2021，12，1： | 2 |
| 2 | Towards harmonization of quality indicators in laboratory medicine 显示文摘 | Plebani M Chiozza ML Sciacovelli L | 2013 | Clin Chem Lab Med2013，51，1： | 1 |
| 3 | FMEA: a model for reducing medical er- rors显示文摘 | Chiozza ML Ponzetti C | 2009 | Clin Chim Acta2009，40，1： | 1 |
| 4 | FMEA: a model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 5 | Pharmacological closure of patent ductus arteriosus:effects on pulse pressure and on endothelin-1 and vasopressin excretion显示文摘 | Zanardo V Vedovato S Chiozza L | 2008 | Am J Perinatol2008，25，6： | 1 |
| 6 | FMEA: A model for reducing medical errors 显示文摘 | Maria Laura Chiozza Clemente Ponzetti | 2009 | Clinica Chimica Acta2009，404，1： | 1 |
| 7 | FMEA: A model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Act2009，404，1： | 1 |
| 8 | Clinical Governance: From clinical risk management to continuous quality improvement显示文摘 | Chiozza ML Plebani M | 2006 | Clin Chem Lab Med2006，44，6： | 1 |
| 9 | Towards har- monization of quality indicators in laboratory medi cine显示文摘 | Plebani M Chiozza ML Sciacovelli L | 2013 | Clin Chem hb Med2013，51，1： | 1 |
| 10 | Nocturnal enuresis in the adolescent:a neglected problem 显示文摘 | Nappo S Delgado R Chiozza ML | 2002 | BJUI2002，90，8： | 1 |
| 11 | FMEA:a model for reducing medical errors显示文摘 | Chiozza ML Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 12 | FMEA:A model for reducing medical errors显示文摘 | Chiozza M L Ponzetti C | 2009 | Clin Chim Acta2009，404，1： | 1 |
| 13 | Towards harmonization of quality indicators in laboratory medicine 显示文摘 | Plebani M Chiozza ML Sciacovelli L | 2013 | Clin Chem Lab Med2013，51，1： | 1 |
| 14 | FMEA: A model for reducing medical errors显示文摘 | Maria Laura Chiozza Clemente Ponzetti | 2009 | Clinica Chimica Acta2009，，1： | 1 |
| 15 | Nocturnal enuresis in the adolescent: a neglected problem显示文摘 | NAPPO S DEL GADO R CHIOZZA M L | 2002 | BJU Int2002，90，9： | 1 |
| 16 | A World Without the West显示文摘 | Naazneen Barma Giacomo Chiozza Ely Ratuer Steve Weber | | 0，，： | 1 |
| 17 | Nocturnal enuresis in the adolescent : a neglected problem 显示文摘 | Nappo S Del Gado R Chiozza M L | 2002 | BJU Int2002，90，9： | 1 |
| 18 | FMEA:A model for reducing medical er- rors显示文摘 | Maria Laura Chiozza Clemente Pon- zetti | 2009 | Clinica Chimica Acta2009，404，： | 1 |
| 19 | FMEA: A model for reducing medical errors显示文摘 | Maria Laura Chiozza Clemente Ponzetti | 2009 | Clinica Chimica Acta2009，，1： | 1 |
| 20 | FMEA:a model for reducing medical errors显示文摘 | Chiozza ML Ponzetti C | | 0，，01： | 1 |
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