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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation显示文摘Mammalian target of rapamycin, also known as me-chanistic target of rapamycin(m TOR) is a protein kinase that belongs to the PI3K/AKT/m TOR signaling pathway, which is involved in several fundamental cellular functions such as cell growth, proliferation, and survival. This protein and its associated pathway have been implicated in cancer development and the regulation of immune responses, including the rejection response generated following allograft transplantation. Inhibitors of m TOR(m TORi) such as rapamycin and its derivative everolimus are potent immunosuppressive drugs that both maintain similar rates of efficacy and could optimize the renal function and diminish the side effects compared with calcineurin inhibitors. These drugs are used in solid-organ transplantationtoinduceimmunosuppression while also promoting the expansion of CD4+CD25+FOXP3+ regulatory T-cells that could favor a scenery of immu-nological tolerance. In this review, we describe the mechanisms by which inhibitors of m TOR induce sup-pression by regulation of these pathways at different levels of the immune response. In addition, we par-ticularly emphasize about the main methods that are used to assess the potency of immunosuppressive drugs, highlighting the studies carried out about immunosuppressive potency of inhibitors of m TOR. | Alberto Baroja-Mazo Beatriz Revilla-Nuin Pablo Ramírez José A Pons | 2016 | World Journal of Transplantation2016，6，1： | 8 |
| 3 | Intestinal preparation prior to capsule endoscopy administration显示文摘In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, some authors have evaluated different regimens of preparation. There is no consensus about the necessity of intestinal preparation for capsule endoscopy and it should be interesting to develop adequate guidelines to improve its efficacy and tolerability. Moreover, the effect of preparation type (purgative) on intestinal transit time is not clear. Since a bowel preparation cannot defini-tively improve its visibility (and theoretically the yield of the test), it is not routinely recommended. | Vicente Pons Beltrán Cristina Carretero Begoa Gonzalez-Suárez Iaqui Fernández-Urien Miguel Muoz-Navas | 2008 | World Journal of Gastroenterology2008，14，37： | 5 |
| 4 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 5 | Circadian rhythms in renal function in hypertensive TGR (mRen-2)27 rats and their nnrmotentive controls显示文摘 | Pons M Schnecko A Witte K | 1996 | Am J physio1996，271，： | 2 |
| 6 | Eu3+-and Tm3+-doped yttrium oxide thin films for optical applications 显示文摘 | PONS Y MOLL O HUIGNARD A ANTIC-FIDANCEV E | 2000 | J Lumin2000，87，： | 2 |
| 7 | A robot for aided fruit harvesting显示文摘 | CERES R PONS J L JIMENEZ A R | 1998 | Industrial Robot1998，25，5： | 1 |
| 8 | Miniature coplanar bandstop filter for Ka-band applications based on original resonant coupling irises topology显示文摘 | Takacs A Aubert H Pons P | 2004 | IEEE Electronics Letters2004，40，2： | 1 |
| 9 | 显示文摘 | Pons Y Moll O Huignard A Antic-Fidancev E | 2000 | Journal of Luminescence2000，8789，： | 1 |
| 10 | Strontium-89 for palliation of pain from bone metastases in patients with prostate and breast cancer显示文摘 | Pons F Herranz R Garcia A | 1997 | Eur J Nucl Med1997，24，： | 1 |
| 11 | A survey of computer vision methods for locating fruit on trees显示文摘 | JIMéNEZ A R CERES R PONS J L | 2000 | Transaction of ASAE2000，43，6： | 1 |
| 12 | A vision system based on a laser range-finder applied to robotic fruit harvesting 显示文摘 | Jim~nez A R Cerse R Pons J L | 2000 | Machine Vision and Applications2000，11，6： | 1 |
| 13 | Bleaching of off-colored cottonseed oils显示文摘 | Walter A Pons J R | 1961 | JAOCS1961，38，： | 1 |
| 14 | Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD显示文摘 | Noguera A Sala E Pons AR | 2004 | Chest2004，125，： | 1 |
| 15 | Design features for bobbin friction stir welding tools: Development of a conceptual model linking the underlying physics to the production process显示文摘 | Sued M K Pons D LavroffJ et a/ | 2014 | Materials and Design2014，，54： | 1 |
| 16 | Design and implementation of an aided fi'uit-harvesting robot (Agribot) 显示文摘 | Ceres R Pons J L Jimnez A R | 1998 | IndustrialRobot1998，5，5： | 1 |
| 17 | Electrical endurance and reliability of circuit-breakers common experience and praclice of two utilitles显示文摘 | PONS A ASBOT A BABUSCI G | 1993 | IEEE Trans on Power Delivery1993，8，1： | 1 |
| 18 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 19 | Transformation behaviour and martensite stabilization in the ferromagnetic Co-Ni-Ga Heusler alloy显示文摘 | CHERNENKO V A PONS J CESARI E | 2004 | Scripta Materialia2004，50，： | 1 |
| 20 | Transformation behavior and martensite stabilization in the ferromagnetic Co-Ni-Ga Heusler alloy 显示文摘 | Chernenko V A Pons J Cesari E | 2004 | Scripta Materialia2004，50，2： | 1 |
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