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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | PBL:教育实践和研究的未来挑战显示文摘本文是一篇有关PBL的评论性研究,根据现代学习理论,作者论述了四个有关学习的原则,解释了这些原则在PBL中的应用,并对已进行的研究进行了评议。 | Diana HJM Dolmans Willem De Grave Ineke HAP Wolfhagen Cees PM van der Vleuten 梅人朗 | 2008 | 复旦教育论坛2008，6，1： | 44 |
| 3 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 4 | 青藏高原东部地区发现的新种:石渠棘球绦虫的生物学特征显示文摘青藏高原东部是细粒棘球绦虫和多房棘球绦虫的混合流行区,诸多的家畜和野生动物参与了棘球绦虫的传播。近年来,一种未知的棘球绦虫先后从高原鼠兔(Ochotona curzoniae)和藏狐(Vulpes ferrilata)中被分离出来。由于其特有的形态学、分子遗传学、寄生宿主和地理分布特征,而被作为新种——石渠棘球绦虫(Echinococcus shiquicus,Xiaoetal,2005)进行了系统研究。本文对该虫种的生物遗传学和流行病学特征进行了讨论,并提出了理论上的假设来解释一些仍不十分清楚的现象。 | 肖宁 邱加闽 Nakao M 李调英 陈兴旺 Schantz PM Craig PS Ito A | 2008 | 中国寄生虫学与寄生虫病杂志2008，26，4： | 29 |
| 5 | 枸橼酸氯米芬加二甲双胍和枸橼酸氯米芬加安慰剂在新近诊断为多囊卵巢综合征妇女诱导排卵中的作用显示文摘 | Moll E Bossuyt PM Korevaar JC 菅鑫妍 | 2006 | 中国处方药2006，5，9： | 23 |
| 6 | Non-invasive assessment of barrier integrity and function of the human gut显示文摘Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function. | Joep Grootjans Geertje Thuijls Froukje Verdam Joep PM Derikx Kaatje Lenaerts Wim A Buurman | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 18 |
| 7 | Improving the outcomes in oncological colorectal surgery显示文摘During the last several decades,colorectal cancer surgery has experienced some major perioperative improvements.Preoperative risk-assessment of nutrition,frailty,and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy,contributed to improved postoperative outcomes.Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety.After an initially indecisive start due to uncertainty about oncological safety,the most significant improvement in intraoperative care was the introduction of laparoscopy.Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes,whereas long-term outcomes regarding survival and recurrence rates are comparable.Nevertheless,long-term results in rectal surgery remain to be seen.Early recognition of anastomotic leakage remains a challenge,though multiple improvements have allowed better management of this complication. | Jeroen LA van Vugt Kostan W Reisinger Joep PM Derikx Djamila Boerma Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 8 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 9 | Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion显示文摘Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion(IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the(potential) future clinical implications. | Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2016 | World Journal of Gastroenterology2016，22，9： | 11 |
| 10 | 非洲裔美国人体力活动与高血压发生的相关性显示文摘非洲裔美国人在美国各种族(民族)中高血压患病率(男性为40.8%,女性为41.5%)最高。有证据表明,与美国其他种族(民族)相比,非洲裔美国人高血压与因心肌梗死、脑卒中和终末期肾脏疾病引起的过早功能丧失和死亡呈不成比例地升高相关。需要确定控制非洲裔美国人危险因素的措施,以减轻其发生高血压的风险。在许多其他人群中已证实,体力活动对预防高血压有保护作用。因此,高血压指南推荐采用体力活动作为预防性生活行为方式。 | Diaz KM Booth JN 3rd Seals SR Abdalla M Dubbert PM Sims M Ladapo JA Redmond N Muntner P Shimbo D | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 11 | Non-invasive markers of gut wall integrity in health and disease显示文摘The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content(external environment) from the host(internal environment).Disruption of this delicate balance at the mucosal interface is the basis for numerous(intestinal) diseases.Experimental animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes,including post-operative or post-traumatic systemic inflammatory response syndrome,sepsis,and multiple organ failure.Assessment of gut wall integrity in clinical practice is still a challenge,as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic tools.Moreover,non-invasive,rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal disorders.This review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity. | Joep PM Derikx Misha DP Luyer Erik Heineman Wim A Buurman | 2010 | World Journal of Gastroenterology2010，16，42： | 9 |
| 12 | 纤维调节素在大鼠正常牙周组织中的免疫化学定位和表现显示文摘目的 研究纤维调节素 (fibromodulin)在正常牙周组织中的分布和表现 ,以明确纤维调节素在牙周组织自身稳定中的作用。方法 用免疫组织化学和逆转录 -聚合酶链反应技术 ,对正常Lewis鼠磨牙牙周组织的纤维调节素及相关蛋白多糖和胶原的组织分布和牙周细胞的mRNA表现进行分析。结果 纤维调节素在靠近口腔牙龈面的区域和牙周韧带 牙槽骨、牙周韧带 牙骨质界面有强阳性表现 ;核心蛋白聚糖强阳性表现于牙龈组织龈沟附近的区域 ;双糖链蛋白聚糖则在牙龈上皮着色明显。从mRNA的表现可以看出 ,纤维调节素 ,核心蛋白聚糖和双糖链蛋白聚糖在成骨细胞中强烈表现 ,其蛋白密度是其他两种细胞的 1~ 3倍 ;Ⅰ型、Ⅲ型胶原的mRNA在牙龈成纤维细胞中表现水平较高 ,其蛋白密度是其他两种细胞的 1 5倍以上。结论 纤维调节素可能与其他小蛋白多糖相互作用 ,调节胶原纤维的网络形成 。 | 钱虹 樊明文 Xiao Y Bartold PM | 2003 | 中华医学杂志2003，83，19： | 8 |
| 13 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 14 | 钠摄入量与血压的关系随能量摄入而变化:终止高血压膳食研究-钠试验的二次分析显示文摘膳食钠的摄入量是以绝对量(mg/d)表示而不是以钠密度(mg/kcal)表示的。研究者旨在确定钠摄入量与血压关系的强弱是否随着能量摄入量而变化。终止高血压膳食研究(dietary approaches to stop hypertension,DASH)-钠试验是比较2种膳食(DASH和对照)和3种钠密度水平的随机膳食摄入试验。 | 刘青 叶鹏 Murtaugh MA Beasley JM Appel LJ Guenther PM McFadden M Greene T Tooze JA | 2018 | 中华高血压杂志2018，26，6： | 7 |
| 15 | 吻合口漏增加结肠癌根治术后远处转移率及长期死亡率:一项丹麦全国队列研究显示文摘背景和目的结直肠癌为世界最常见恶性肿瘤之一。全球每年约有120万新发病例,60万人死于本病。手术切除是患者长期无病生存的关键手段,但术后并发症却可对手术结局产生重要影响。吻合口瘘(anastomotic leak,AL)是结直肠癌根治手术的严重并发症类型,直接增加术后短期死亡率。根据不同手术类型,AL发生率约在3%至12%之间。目前仅有为数不多结果却彼此矛盾的研究关注结肠癌术后吻合口瘘对于肿瘤结局及长期生存的影响。而对于直肠癌患者的研究结果则一致显示AL与局部复发率及长期死亡率增加相关,而不影响远处转移发生率。与之相反,尚未有研究证实结肠癌术后AL与局部复发或远处转移相关。已有研究证实,AL可降低结肠癌患者的无病生存期及总生存期。本项针对结肠癌的丹麦全国性研究主要终点为确定AL对结肠癌术后存活超过120天以上患者局部复发及远处转移率的影响;次要终点为确定AL对患者长远期死亡率的影响。此外,通过一项亚组分析,评价AL对III期结肠癌患者实施辅助化疗(AC)的影响。方法本研究为一项丹麦全国范围的队列研究,所有9333例患者均来自丹麦结直肠癌研究组数据库,并结合丹麦病理登记系统与国家患者登记系统的相关数据。通过多变量Cox回归分析对混杂因素进行校正。结果研究结果表明,患者AL发生率为6.4%,术后120天内死亡744例。其余的8589例患者中,局部复发861例(10.0%),但与AL无关(校正风险比HR=0.78;95%CI:0.55~1.12;P=0.184)。远处转移1281例(14.9%),且AL患者远处转移发生率更高(校正HR=1.42,95%CI:1.13~1.178;P=0.003)。AL也与患者长期死亡率呈正相关(校正HR=1.20,95%CI:1.01~1.44;P=0.042)。在2841例III期患者中,AL与施行辅助化疗的可能性降低(校正HR=0.58,95%CI:0.45~0.74;P<0.001)以及初始治疗延迟显著相关(校16天,95%CI:12~20天;P<0.001)。结论结肠癌术后吻合口瘘显著增加远处转移发生率及长期全因死亡率。该结果或在部分程度上与取消或延迟辅助化疗相关。 | Krarup PM Nordholm-Carstensen A orgensen LN 张信华 | 2014 | 消化肿瘤杂志(电子版)2014，0，1： | 7 |
| 16 | 直肠癌术前热疗、放疗及化疗的临床病理意义显示文摘目的 探讨直肠癌手术前热疗、放疗及化疗后临床病理特征。方法 38例局部进展期直肠癌病例进行了手术前热疗、放疗及化疗。局部热疗采用SIGMA60热疗机 (BSD - 2 0 0 0 ) ,放疗总剂量为 45Gy。四氢叶酸 +5 -FU全身化疗共 2个疗程。辅助治疗完成后 4~ 6周手术。结果 经过术前辅助治疗 ,肿瘤的直径平均缩小 35 .5 %。 4例 (1 0 .5 % )达到病理完全缓解 ,另外 2 7例 (71 .0 % )达到PR(癌细胞坏死率≥ 50 % ) ,总有效率达 81 .6 %。辅助治疗后淋巴结阳性率由 68.4 %降至 44 .7%。病理检查所有肿瘤均有不同程度的癌细胞变性、细胞结构破坏、肿瘤血管破坏、出血及大片凝固性坏死。瘢痕区域可见灶性钙化、再生上皮。结论 术前热疗、放疗及化疗可以使部分肿瘤获得病理完全缓解、缩小原发瘤。 | 梁寒 郝希山 战中利 Haensch W Schlag PM | 2002 | 肿瘤2002，22，1： | 6 |
| 17 | 血压变异性预测自发性脑出血患者的院内不良预后显示文摘越来越多的证据表明,较高的收缩压变异性(systolicblood pressure variability ,SBPV)可能与脑出血患者的不良预后相关。该研究探讨了 SB PV 与院内脑出血预后之间的关系。研究者在2个医疗系统中收集了10年的自发性脑出血患者的连续数据。记录人口统计学、病史、实验室测试、计算机断层扫描数据、院内治疗情况以及神经和功能评估。在入院后24h内获取血压记录。 | 刘青 叶鹏 Divani AA Liu X Di Napoli M Lattanzi S Ziai W James ML Jafarli A Jafari M Saver JL Hemphill JC Vespa PM Mayer SA Petersen A | 2019 | 中华高血压杂志2019，27，8： | 6 |
| 18 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 19 | Human small intestine is capable of restoring barrier function after short ischemic periods显示文摘AIM To assess intestinal barrier function during human intestinal ischemia and reperfusion(IR).METHODS In a human experimental model,6 cm of jejunum was selectively exposed to 30 min of ischemia(I) followed by 30 and 120 min of reperfusion(R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose(L) and rhamnose(R). Plasma concentrations of citrulline,an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. Damage to the epithelial lining was assessed by immunohistochemistry for tight junctions( TJs),by plasma marker for enterocytes damage(I-FABP) and analyzed by electron microscopy(EM) using lanthanum nitrate as an electrondense marker.RESULTS Plasma L/R ratio's were significantly increased after 30 min of ischemia(30 I) followed by 30 min of reperfusion(30 R) compared to control(0.75 ± 0.10 vs 0.20 ± 0.09,P < 0.05). At 120 min of reperfusion(120 R),ratio's normalized(0.17 ± 0.06) and were not significantly different from control. Plasma levels of I-FABP correlated with plasma L/R ratios measured at the same time points(correlation: 0.467,P < 0.01). TJs staining shows distortion of staining at 30 I. An intact lining of TJs was again observed at 30 I120 R. Electron microscopy analysis revealed disrupted TJs after 30 I with paracellular leakage of lanthanum nitrate,which restored after 30 I120 R. Furthermore,citrulline concentrations closely paralleled the histological perturbations during intestinal IR.CONCLUSION This study directly correlates histological data with intestinal permeability tests,revealing that the human gut has the ability of to withstand short episodes of ischemia,with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion. | Dirk HSM Schellekens Inca HR Hundscheid Claire AJI Leenarts Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 20 | 结肠癌术后吻合口瘘与患者不良结局有关显示文摘结肠癌术后吻合口瘘是否可增加病情复发风险,目前尚无翔实证据。哥本哈根大学Peter-Martin Krarup博士等人进行了一项研究,该研究对象为经结肠癌根治性切除手术治疗后存活120天的结肠癌患者,目的为考查结肠癌术后吻合口瘘对患者病情复发与长期死亡的影响。这项研究结果发表于2013年9月16日在线出版的《外科学年鉴》( Annals of Surgery )杂志上。 这是一项对登记于丹麦结直肠癌研究组数据库中的9333例患者进行的前瞻性研究。研究结果表明,患者结肠癌术后吻合口瘘发生率为6.4%,有744例患者于120天内死亡。在其余的8589例患者中,有861例(10.0%)出现局部复发,但与结肠癌术后吻合口瘘无关。1281例(14.9%)患者出现远端复发,远端复发常发生于结肠癌术后吻合口瘘后。结肠癌术后吻合口瘘也与患者远期死亡率有关。在2841例III期患者中,结肠癌术后吻合口瘘与辅助化疗可能性增加和初始治疗延迟有关。 | Krarup PM Nordholm-Carstensen A Jorgensen LN | 2013 | 中华结直肠疾病电子杂志2013，2，4： | 4 |
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