|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Approaches to functional genomics in filamentous fungi显示文摘在细丝状的真菌的基因功能的学习是在很最近的年里做了大进展的研究的一个领域。很多转变和基因操作策略被开发了并且适用于经济地重要的细丝状的真菌和 oomycetes 的一张多样、很快膨胀的表。与真菌的染色体的重要数字,定序的现在或被定序的、功能的基因组学答应揭开来年里的很多新信息。这评论讨论在在细丝状的真菌检验基因功能被做了并且描述不同途径的优点和限制的最近的进展。 | Richard J Weld Kim M Plummer Margaret A Carpenter Hayley J Ridgway | 2006 | Cell Research2006，16，1： | 19 |
| 2 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 3 | Global burden of cancers attributable to infections in 2008: a review and synthetic analysis显示文摘 | Catherine de Martel Jacques Ferlay Silvia Franceschi Jér?me Vignat Freddie Bray David Forman Martyn Plummer | 2012 | Lancet Oncology2012，，6： | 3 |
| 4 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 5 | Influence of β nucleation on the mechanical properties of isotactic polypropylene and rubber modified isotactic polypropylene 显示文摘 | Grein C Plummer C J G Kausch H H | 2002 | J Polymer2002，43，： | 1 |
| 6 | Twentieth century trends in climate extremes over the Australian region and New Zealand 显示文摘 | Plummer N Salinger M J Nicholls N | 1999 | Climatic Change1999，42，1： | 1 |
| 7 | Phase separation in epoxy resin-reactive dendritic hyperbranched polymer blends显示文摘 | PLUMMER C J G MEZZENGA R BOOGH L | 2001 | Polymer Engineering and Science2001，41，： | 1 |
| 8 | Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis显示文摘 | Clifford G M Smith J S Plummer M | 2003 | Br J Cancer2003，88，1： | 1 |
| 9 | Fingerprinting of cauliflower cultivars using RAPD markers显示文摘 | ASTARINI I A PLUMMER J A LANCASTER R A | 2004 | Australian Journal of Agricultural Research2004，55，： | 1 |
| 10 | Solution proper- ties of star and linear poly(N-isopropylaerylamide)显示文摘 | Plummer R Hill D J T Whittaker A K | 2006 | Macromolecules2006，39，24： | 1 |
| 11 | Effects of Chlorine and Ozone on Algal Cell Properties and Removal of Algae by Coagulation 显示文摘 | Plummer J D Edward J K | 2002 | Water Supply: Research and Technology2002，51，6： | 1 |
| 12 | Micro-ntcchmisms ,f slow crack growth in polyethylene under constant tensile loading 显示文摘 | Plummer C J G Goldberg A Ghanem A | 2001 | Polymer2001，42，23： | 1 |
| 13 | Morphology build-up in dendritic hyperbranehed polymer modified epoxy resins : modelling and characterization 显示文摘 | MEZZENGA R PLUMMER C J G BOOGH L | 2001 | Polymer2001，42，： | 1 |
| 14 | Scaling theory for cylindrical, fully-depleted, surrounding-gate MOSFET's 显示文摘 | Plummer J D | 1997 | IEEE Trans Elec Dev Lett1997，18，2： | 1 |
| 15 | Distributions and seasonal variability of pH and alkalinity in the Tweed Estuary, U K显示文摘 | Howland R J M Tappin A D Uncles R J Plummer D H and Bloomer N J | 2000 | The Science of the Total Environment2000，，： | 1 |
| 16 | Influence of β Nucleation on the Mechanical Properties of Isotactic Polypropylene and Rubber Modified lsotactic Polypropylene显示文摘 | Grein C Plummer C J G Kausch H H | 2002 | Polymer2002，43，11： | 1 |
| 17 | Chemoprevention of precancerous gastric lesions with antioxidant vitamin supplementation:a randomized trial in a high-risk population显示文摘 | Plummer M Vivas J Lopez G | 2007 | J Natl Cancer Inst2007，99，2： | 1 |
| 18 | Environmental factors in helicobacter pylori-related gastric precancerous lesions in venezuela 显示文摘 | KATO I VIVAS J PLUMMER M | 2004 | Cancer Epidemiol Biomarkers Prev2004，13，3： | 1 |
| 19 | The use of simulation and multiple environmental tracers to quantify groundwater flow in a shallow aquifer显示文摘 | Reilly T E Plummer L N Phillips P J | 1994 | Water Resources Research1994，30，： | 1 |
| 20 | Antimicrobial properties of AUium sativura (garlic)显示文摘 | HARRIS J C COTTRELL S L PLUMMER S | 2001 | Appl Microbiol Biotechnol2001，57，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员