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| 1 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 2 | Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility显示文摘 | Pires ES Meherji PK Vaidya RR | 2007 | J Histochem Cytochem2007，55，12： | 1 |
| 3 | Specific and sensitive im-munoassays detect multiple anti-ovarian antivodies in women with Infertility 显示文摘 | Pires ES Meheriji PK Vaidva RR | 2007 | J Histoehem Cytochem2007，55，12： | 1 |
| 4 | Can anti-ovarian antibody testing be useful in an IVF-ET clinic? 显示文摘 | Pires ES Parikh FR Mande PV | 2011 | J Assist Reprod Genet2011，28，1： | 1 |
| 5 | Specific and sensitive immunoassays detect multiple anti-ovarian antivodies in women with infertility显示文摘 | Pires ES Meheriji PK Vaidva RR | 2007 | J Histochem Cytochem2007，55，12： | 1 |
| 6 | Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility显示文摘 | Pires ES Meherji PK Vaidya RR | 2007 | Histochem Cytochem2007，55，12： | 1 |
| 7 | Comparison of two- and three-dimensional ultrasonography in the evaluation of fetal heart: image quality and time spent in the exam显示文摘 | Hélio Antonio Guimar?es Filho Lavoisier Linhares Dias da Costa Edward Araujo Júnior Sebasti?o Marques Zanforlin Filho Cláudio Rodrigues Pires Luciano M. M. Nardozza Antonio Fernandes Moron Rosiane Mattar | 2007 | Archives of Gynecology and Obstetrics2007，，3： | 1 |
| 8 | Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility显示文摘 | Pires ES Meherji PK Vaidya RR | 2007 | Histochem Cytochem2007，55，12： | 1 |
| 9 | A block in the road to fertility :autoantibodies to heat-shock protein 90-13 in human ovarian autoimmunity 显示文摘 | Pires ES Khole VV | 2009 | Fertil Steril2009，92，4： | 1 |
| 10 | Prevalance of uterine defects in habituel abortion patients attended on at a University Health Service in Brazil 显示文摘 | Guimar? es Filho HA Mattar R Pires CR | 2006 | Arch Gynecol Obstet2006，274，6： | 1 |
| 11 | Genetic diversity, antimicrobial resistance and toxigentic profiles of Bacillus cereus isotlated from food in Brazil over three decades显示文摘 | Chaves JQ Pires ES Vivoni AM | 2011 | Int J Food microbiol2011，147，1： | 1 |
| 12 | Genetic diversity, antimicrobial resistance and toxigenic profiles of Bacillus cereus isolated from food in Brazil over three deeades显示文摘 | Chaves JQ Pires ES Vivoni AM | 2011 | Int J Food Mierobiol2011，147，1： | 1 |
| 13 | Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility显示文摘 | Pires ES Meherji PK Vaidya RR Parikh FR Ghosalkar MN Khole VV | 2007 | J Histochem Cytochem2007，55，12： | 1 |
| 14 | Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients显示文摘BACKGROUND Systemic autoimmune rheumatic diseases(SARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and fatigue.Patients with SARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of symptoms.In this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of life.AIM To assess the efficacy of transcranial direct current stimulation(tDCS)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with SARDs.METHODS This study included nine patients with different types of SARDs.All patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after infection.Anodal tDCS was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise program.All participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCS protocol),and one week after tDCS protocol.During all procedures,the patients’treatments remained unchanged.RESULTS The sample comprised eight women and one man with a mean age of 48.7±9.6 years.After the tDCS protocol,pain and fatigue significantly improved on the visual analog scale(P<0.05).The physical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand test.None of the patients experienced any adverse events.CONCLUSION The present study showed that tDCS in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in SARDs patients with post-COVID-19 syndrome. | Rafael Giovani Missé Alexandre Moura dos Santos Isabela Bruna Pires Borges Marlise Sítima Mendes Simões Lorenza Rosa Silvério Bruna Lindoso Correia Ana Wook Sook Kim Aline Marques Caetano Sandra Gofinet Pasoto Carla Gonçalves Schahin Saad Diogo Souza Domiciano Clarice Tanaka Julia Maria D’Andrea Greve Abrahão Fontes Baptista Samuel Katsuyuki Shinjo | 2023 | World Journal of Rheumatology2023，11，1： | 0 |
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