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| 1 | Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B显示文摘AIM: To study the efficacy and safety of Fuzhenghuayu capsule (FZHY capsule, a capsule for strengthening body resistance to remove blood stasis) against liver fibrosis due to chronic hepatitis B. METHODS: Multicenter, randomized, double blinded and parallel control experiment was conducted in patients (aged from 18 to 65 years) with liver fibrosis due to chronic hepatitis B. Hepatic histologic changes and HBV markers were examined at wk 0 and 24 during treatment. Serologic parameters (HA, LM, P-Ⅲ-P, Ⅳ-C) were determined and B ultrasound examination of the spleen and liver was performed at wk 0, 12 and 24. Liver function (liver function and serologic parameters for liver fibrosis) was observedat wk 0, 6, 12, 18 and 24. Blood and urine routine test, renal function and ECG were examined before and after treatment. RESULTS: There was no significant difference between experimental group (110 cases) and control group (106 cases) in demographic features, vital signs, course of illness, history for drug anaphylaxis and previous therapy, liver function, serologic parameters for liver fibrosis, liver histologic examination (99 cases in experimental group, 96 cases in control group), HBV markers, and renal function. According to the criteria for liver fibrosis staging, meanscore of fibrotic stage(s) in experimental group after treatment (1.80) decreased significantly compared to the previous treatment (2.33, P<0.05), but there was no significant difference in mean score of fibrotic stage(s) (2.11 and 2.14 respectively). There was a significant difference in reverse rate between experimental group (52%) and control group (23.3%) in liver biopsy. With marked effect on decreasing the mean value of inflammatory activity and score of inflammation (P<0.05), Fuzhenghuayu capsule had rather good effects on inhibiting inflammatory activity and was superior to that of Heluoshugan capsule. Compared to that of pretreatment, there was a significant decrease in HA, LM, P-Ⅲ-P and Ⅳ-C content in experimental group after 12 and 24 wk of treatment. The difference in HA, LM, P-Ⅲ-P and Ⅳ-C content between 12 and 24 wk of treatment and pretreatment in experimental group was significantly greater than that in control group (P<0.01-0.05). The effect, defined as two of four parameters lowering more than 30% of the baseline, was 72.7% in experimental group and 27.4% in control group (P<0.01). Obvious improvement in serum Alb, ALT, AST and GGT was seen in two groups. Compared to that of control group, marked improvement in GGT and Alb was seen in experimental group (P<0.05). The effective rate of improvement in serum ALT was 72.7% in experimental group and 59.4% in control group. No significant difference was seen in blood and urine routine and ECG before and after treatment. There was also no significant difference in stable rate in ALT and serologic parameters for liver fibrosis between experimental group and control group after 12 wk of withdrawal. CONCLUSION: Fuzhenghuayu capsule has good therapeutic effects on alleviating liver fibrosis due to chronic hepatitis B without any adverse effect and is superior to that of Heluoshugan capsule. | PingLiu Yi-YangHu ChengLiu Lie-MingXu Cheng-HaiLiu Ke-WeiSun De-ChangHu You-KuanYin xia-QiuZhou Mo-BinWan XiongCai Zhi-QingZhang JUNYe Ren-XingZhou JiaHe Bao-ZhangTang | 2005 | World Journal of Gastroenterology2005，11，19： | 60 |
| 2 | Prediction of Properties in Thermomechanically Treated Cu-Cr-Zr Alloy by an Artificial Neural Network显示文摘A supervised artificial neural network (ANN) to model the nonlinear relationship between parameters of thermomechanical treatment processes with respect to hardness and conductivity properties was proposed for Cu-Cr-Zr alloy. The improved model was developed by the Levenberg-Marquardt training algorithm. A basic repository on the domain knowledge of thermomechanical treatment processes is established via sufficient data acquisition by the network. The results showed that the ANN system is an effective way and can be successfully used to predict and analyze the properties of Cu-Cr-Zr alloy. | JuanhuaSU QimingDONG PingLIU HejunLI BuxiKANG | 2003 | Journal of Materials Science & Technology2003，19，6： | 11 |
| 3 | Preparation of human hepatocellular carcinoma-targeted liposome microbubbles and their immunological properties显示文摘AIM: To prepare the human hepatocellular carcinoma_(HCC)targeted liposome microbubbles and to investigate their immunological properties.METHODS: Human hepatocarcinoma specific monoclonal antibody HAb18 was attached to the surface of home-made liposome microbubbles by static attraction to prepare the targeted liposome microbubbles. The combination of HAb18 with liposome microbubbles was confirmed by the slide agglutination test and immunofluorescent assay. Their immunological activity was measured by ELISA. Rosette formation test, rosette formation blocking test and immunofluorescent assay were used to identify the specific binding of targeted liposome microbubbles to SMMC-7721 hepatoma cells, and cytotoxicity assay was used to detect their effect on human hepatocytes.RESULTS: The targeted liposome microbubbles were positive in the slide agglutination test and immunofluorescent assay. ELISA indicated that the immunological activity of HAb18 on the liposome microbubbles was similar to that of free HAb18. SMMC-7721 cells were surrounded by the targeting liposome microbubbles to form rosettes, while the control SGC-7901 gastric cancer cells were not. Proliferation of SMMC-7721 cells and normal human hepatocytes was not influenced by the targeted liposome microbubbles.CONCLUSION: The targeted liposome microbubbles with a high specific biological activity have been successfully prepared, which specifically bind to human hepatocarcinoma cells, and are non-cytotoxic to hepatocytes. These results indicate that the liposome microbubbles can be used as a HCC-targeted ultrasound contrast agent that may enhance ultrasound images and thus improve the diagnosis of HCC,especially at the early stage. | Ai-NaBian Yun-HuaGao Kai-BinTan PingLiu Gong-JunZeng XinZhang ZhengLiu | 2004 | World Journal of Gastroenterology2004，10，23： | 11 |
| 4 | Microstructural Changes of Cu-Ni-Si Alloy during Aging显示文摘Age hardening in Cu-3.2Ni-0.75Si (wt pct) and Cu-1.0Ni-0.25Si (wt pct) alloys from 723 to 823 K is studied. After an incubation period strengthening appears which is due to precipitates in the Cu-1.0Ni-0.25Si (wt pct) alloy. On other hand animmediate increase of the yield strength characterizes the aging of the alloy. This is followed by the regions of constant yield strength and further by a peak. The microstructure of the alloy was studied by, means of transmission electron microscope (TEM) and X-ray diffraction (XRD). Spinodal decomposition takes place followed by nucleation of the ordering coherent (Cu,Ni)3Si particles, further precipitation annealing coherent δ-Ni2Si nucleated within the (Cu,Ni)3Si particle. Any change of the yield strength can be described by an adequate change of the structure in the sample. The nature of the aging curves with a'plateau' is discussed. The formulas of Ashby and Labusch can be used to explain the precipitation. | QimingDONG DongmeiZHAO PingLIU BuxiKANG JinliangHUANG | 2004 | Journal of Materials Science & Technology2004，20，1： | 5 |
| 5 | Grey scale enhancement of rabbit liver and kidney by intravenous injection of a new lipid-coated ultrasound contrast agent显示文摘AIM: To assess the grey scale enhancement of a new lipidcoated ultrasound contrast agent in solid abdominal organs as liver and kidney.METHODS: Size distribution and concentration of the lipidcoated contrast microbubbles were analyzed by a Coulter counter. Two-dimensional (2D) second harmonic imaging of the hepatic parenchyma, the inferior vena cava and the right kidney of the rabbits were acquired before and after contrast agent injection. Images were further quantified by histogram in Adobe Photoshop 6.0. Time-intensity curves of hepatic parenchyma, inferior vena cava and renal cortex were qenerated from the oriqinal qrev scale.RESULTS: The 2D images of hepatic parenchyma and cortex of the kidney were greatly enhanced after injection and the peak time could last more than 50 min.CONCLUSION: This new lipid ultrasound contrast agent could significantly enhance the grey scale imaging of the hepatic parenchyma and the renal cortex for more than 50 min. | PingLiu Yun-HuaGao Kai-BinTan ZhengLiu SongZuo | 2004 | World Journal of Gastroenterology2004，10，16： | 3 |
| 6 | Preparation of superabsorbent based on the graft copolymerization of acrylic acid and acrylamide onto konjac glucomannan and its application in the water retention in soils显示文摘 | Da‐TingTian Shi‐RongLi Xin‐PingLiu Jing‐ShouWang ShengHu Cheng‐MeiLiu Hong‐QuanXie | 2012 | J Appl Polym Sci2012，，4： | 2 |
| 7 | 1,3,5‐Triphenylhexahydro‐1,3,5‐triazine – active intermediate and precursor in the novel synthesis of benzoxazine monomers and oligomers显示文摘 | ZdenkaBrunovska Jin PingLiu | 1999 | Macromol. Chem. Phys1999，，7： | 1 |
| 8 | High‐Sensitivity C‐Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese显示文摘 | YueHuang JingJing Xing‐QuanZhao Chun‐XueWang Yi‐LongWang Gai‐FenLiu Chun‐JuanWang Li‐PingLiu Xiao‐MengYang YanJiao YunJiao Li‐ShiWang Yong‐JunWang Wei‐KuanGu | 2012 | CNS Neuroscience & Therapeutics2012，，3： | 1 |
| 9 | Long‐term survival after surgical management of neuroendocrine hepatic metastases显示文摘 | Evan S.Glazer Jennifer F.Tseng WaddahAl‐Refaie Carmen C.Solorzano PingLiu Katherine A.Willborn Eddie K.Abdalla Jean‐NicolasVauthey Steven A.Curley | 2010 | HPB2010，，6： | 1 |
| 10 | Aging Kinetics in a CuNiSiCr Alloy显示文摘The aging precipitation behavior in solution treated Cu-Ni-Si-Cr alloy has been studied in terms of the analyses of the variations in electrical conductivity. On the basis of the linear relationship between the electrical conductivity and the volume fraction of the precipitates, the phase transformation kinetics equation was deduced from the Avrami empirical formula. On the basis of this equation, transformation kinetics curves corresponding to 5% and 50% transformation were established. | JingguoLEI PingLIU XiaotianJING DongmeiZHAO JinliangHUANG | 2004 | Journal of Materials Science & Technology2004，20，6： | 1 |
| 11 | Bis(α‐furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone‐induced insulin resistance in 3T3‐L1 adipocytes显示文摘 | Yi‐QingZuo Wei‐PingLiu Yan‐FenNiu Chang‐FuTian Ming‐JinXie Xi‐ZhuChen LingLi | 2010 | Journal of Pharmacy and Pharmacology2010，，10： | 1 |
| 12 | Overexpression and involvement of special AT‐rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells显示文摘 | Qing‐QuanLi Zhong‐QingChen Jing‐DaXu Xi‐XiCao QiChen Xiu‐PingLiu Zu‐DeXu | 2009 | Cancer Science2009，，1： | 1 |
| 13 | Night ventilation research of office buildings part 2:cooling potential of continental climate zone in China显示文摘 | Xin Rongzhu Liu Yang Jia Pingliu | | 0，，： | 1 |
| 14 | Long‐term survival after surgical management of neuroendocrine hepatic metastases显示文摘 | Evan S.Glazer Jennifer F.Tseng WaddahAl‐Refaie Carmen C.Solorzano PingLiu Katherine A.Willborn Eddie K.Abdalla Jean‐NicolasVauthey Steven A.Curley | 2010 | HPB2010，，6： | 1 |
| 15 | Non-silica periodic mesostructured material:recent progress显示文摘 | Abdelhamid sayari PingLiu | 1997 | Microporous Material1997，，12： | 1 |
| 16 | Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli显示文摘 | Natalee Stewart Jingyang Feng Xiao pingliu | 2005 | Microbiology2005，151，： | 1 |
| 17 | Primary Malignant Lymphoma of the Breast: a Study of 15 Cases and Review of the Chinese Literature显示文摘OBJECTIVE To study the clinical features and significant prognostic factors for primary breast lymphoma (PBL).METHODS A retrospective clinical analysis of 15 patients with PBL and a statistical analysis of 134 cases with PBL were performed.RESULTS All 15 patients, but one, were female with a median age of 42years. None were diagnosed with PBL preoperatively. Pathological studyshowed that all cases were non-Hodgkin's lymphoma with the DLCL type(53.3%). The right breast was affected in 10 patients, the left in 4 and both inone. A statistical analysis showed that the size of tumors and treatmentpattern (single or multi-modality) were significant prognostic factors inpredicting the survival time, but the location of the tumor at initialpresentation and the age of the patients were not.CONCLUSION Most PBLs are NHL. The right breast is more frequently involved. The correct diagnosis depends mostly on postoperative pathology. The size of the tumor and the modality of treatment are significant prognostic factors. | ChunhongHu LiqiangZhou PingLiu | 2004 | Chinese Journal of Clinical Oncology2004，1，4： | 0 |
| 18 | Kinetic equation for internal oxidation of Cu-Al alloy cylinders显示文摘The kinetics of internal oxidation of Cu-Al alloy cylinders, containing up to 2.214mol% Al, were investigated in the temperature range of 1023 K to 1273 K, and the depth of internal oxidation was measured in the microscopy. A kinetic equation was derived to describe the internal oxidation of Cu-Al alloy cylinders. For the internal oxidation of Cu-Al alloys employed in the synthesis of alumina dispersion strengthened copper, the kinetic equation can be simplified. The derived equation was checked experimentally by means of oxidation depth measurements and the results show that the derived equation is exact enough to describe the kinetics of internal oxidation of Cu-Al alloy cylinders. Based on this equation and the oxidation depth measurements, the permeability of oxygen in solid copper was obtained. Investigation also shows that there is no evidence for preferential diffusion along grain boundaries in the process of internal oxidation. | KexingSong JiandongXing BaohongTian PingLiu QimingDong | 2005 | Journal of University of Science and Technology Beijing2005，12，3： | 0 |
| 19 | Dynamic Demonstration on Hydrophilicity Protein Molecular of Fibrosing Hepatic Tissue in Rats with Interven-tion of Fuzhenghuayu Decoction显示文摘 | YingLIU PingLIU Cheng-HaiLIU Lie-MingXU Yun-FeiCHEN Yi-YingHU ChenLIU Guang-LiDU BingWANG Yong-PingWU | 2004 | Acta Biochimica et Biophysica Sinica2004，36，1： | 0 |
| 20 | Spatio-temporal Variation of Distribution Patterns in Cunninghamia lanceolata Plantations显示文摘To aid in management of Cunninghamia lanceolata,the main timber species in Southern China,its variation of spatial distribution pattern was analyzed.Three permanent plots of C.lanceolata plantations with approximately the same site conditions,set by China continuous forest inventory in Shunchang,Fujian,were selected. C.lanceolata growth was divided into two stages: young trees(5 cm≤diameter at breast height (DBH)<10 cm) and mature trees(DBH≥10 cm). The DBH and coordinates of every tree(DBH≥5 cm) in the permanent plots were recorded in 2003 and 2008.The function L(r),improvement of Ripley’s K(r),the paircorrelation function g(r),and the uniform angle index(W_i) were used to analyze the spatio-temporal variation of spatial distribution patterns.The three permanent plots had mean uniform angle index(W) between 0.494-0.578 at low altitudes,0.465-0.477 at medium altitudes,and 0.426-0.601 at high altitudes.Results showed that altitude did not affect the spatial distribution pattern. The L(r ) and g(r) function curves of mature trees were generally lower than young trees’,i.e.tend to be more random or uniform distribution.So regardless of the initial distribution of young or mature trees,with the passage of time,there was a tendency for the aggregated distribution to change to a random distribution,and a random distribution to change to a uniform distribution. | Yang Ziqing Chen Pingliu Liu Jian Yu Kunyong Liao Xiaoli You Haochen Gong Conghong | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
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