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| 1 | Hantavirus infection:a global zoonotic challenge显示文摘Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however,hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome(HFRS) and hantavirus cardiopulmonary syndrome(HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide. | Hong Jiang Xuyang Zheng Limei Wang Hong Du Pingzhong Wang Xuefan Bai | 2017 | Virologica Sinica2017，32，1： | 47 |
| 2 | Modern stalagmite oxygen isotopic composition and its implications of climatic change from a high-elevation cave in the eastern Qinghai-Tibet Plateau over the past 50 years显示文摘An oxygen isotope record of a stalagmite from Huanglong Cave in the eastern Qinghai-Tibet Plateau dated with 230Th and 210Pb methods provides variations of the Asian monsoon with an average resolu-tion of 1 year over the past 50 years. This study shows that the δ18O of dripwater in the cave represents the annual mean δ18O of local meteoric precipitation and the stalagmites were deposited in isotopic equilibrium. A comparison of the stalagmite δ18O record with instrumentally meteorological data indi-cates that shifts of the δ18O are largely controlled by the amount effect of meteoric precipitation con-veyed through the southwest monsoon(the Indian monsoon) and less affected by temperature. Therefore,the variations of δ18O record reflect the changes in monsoon precipitation on inter-annual time scales under the influence of the southwest monsoon. Like many other stalagmite δ18O records in the Asian monsoon regions,the δ18O record of the stalagmite from Huanglong Cave also reveals a gradually enriched trend during the past 50 years,i.e. relatively enriched in 18O. This trend may indicate the decline of the Asian monsoon intensity which is consistent with the decrease of monsoon indices. The weakening of the modern Asian monsoon well matched with the temperature changes in strato-sphere,which may illustrate that the weakening of the monsoon mainly results from the lowering of solar radiation. | YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen R. JOHNSON LIU JingHua AN ChunLei | 2007 | Chinese Science Bulletin2007，52，9： | 20 |
| 3 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 4 | Involvement of regulatory volume decrease in the migration of nasopharyn-geal carcinoma cells显示文摘The transwell chamber migration assay and CCD digital camera imaging techniques were used to investigate the relationship between regulatory volume decrease (RVD) and cell migration in nasopharyngeal carcinoma cells (CNE-2Z cells). Both migrated and non-migrated CNE-2Z cells, when swollen by 47% hypotonic solution, exhibited RVD which was inhibited by extracellular application of chloride channel blockers adenosine 5’-triphosphate (ATP), 5-nitro-2-(3- phenylpropylamino) benzoic acid (NPPB) and tamoxifen. However, RVD rate in migrated CNE-2Z cells was bigger than that of non-migrated cells and the sensitivity of migrated cells to NPPB and tamoxifen was higher than that of non- migrated cells. ATP, NPPB and tamoxifen also inhibited migration of CNE-2Z cells. The inhibition of migration was positively correlated to the blockage of RVD, with a correlation coefficient (r) = 0.99, suggesting a functional relation- ship between RVD and cell migration. We conclude that RVD is involved in cell migration and RVD may play an important role in migratory process in CNE-2Z cells. | JianWenMAO LiWeiWANG TimJACOB XueRongSUN HuiLI LinYanZHU PanLI PingZHONG SiHuaiNIE LiXinCHEN | 2005 | Cell Research2005，15，5： | 9 |
| 5 | Implications of stalagmite density for past climate change:An example from stalagmite growth during the last deglaciation from Wanxiang Cave,western Loess Plateau显示文摘The density of a stalagmite(WX42A)from Wanxiang Cave,Wudu County,Gansu Province,China,in the western margin of the Asian summer monsoon region,presents regular fluctuations in different deposition periods during the last deglaciation.Over long timescales,high-precision 230Th dating and high-resolution stalagmite density data indicate that the density-time series between 17644 a BP and 12758 a BP is quite similar to the stalagmite δ18O record which reflects Asian monsoon intensity.Strengthening/weakening(lighter/heavier stalagmite δ18O values)of the Asian monsoon is accompanied by increase/decrease in stalagmite density.Over short timescales,decrease in stalagmite density correlates to monsoon-retreat events such as the Inter-AllerФd Cold Period(IACP),Older Dryas(OD)and Inter-BФlling Cold Period(IBCP).Generally,this kind of decrease in stalagmite density reflects precipitation decrease with weakening of the Asian monsoon,which in turn slows cave dripwater rate and decreases crystal nuclei,leading to enlargement of calcite crystals,weakened biological activity and decreased soil pCO2 which increases the abundance of impure detrital materials in stalagmites.However,during the period of large amplitude reduction of precipitation and biological activity which resulted from extreme monsoon-retreat events,temperature variation would dominate fluctuation of stalagmite density.For example,stalagmite density increased suddenly when temperature dropped suddenly in the north Atlantic during Heinrich event 1(H-1).This may be caused by low seepage water temperature,more dissolved calcium carbonate,compact regular crystals forming under higher supersaturation,leading to the stalagmite increased density.Stalagmite density fluctuation sensitively recorded stalagmite growth history and environment,demonstrating that stalagmite density can be used as a proxy for paleoclimatic research. | ZHANG DeZhong ZHANG PingZhong SANG WenCui CHENG Hai WU XiuPing YUAN Ye BAI YiJun WANG JiangLin JIA JiHong | 2010 | Chinese Science Bulletin2010，55，34： | 7 |
| 6 | Modeling study of source contributions and emergency control effects during a severe haze episode over the Beijing-Tianjin-Hebei area显示文摘In February 2014, the Beijing-Tianjin-Hebei(BTH) area experienced a weeklong episode of heavy haze pollution. Cities such as Beijing(BJ) and Shijiazhuang(SJZ) issued heavy pollution alerts for the first time and took emergency control measures. This study employed the Nested Air Quality Prediction Modeling System(NAQPMS) to simulate and analyze the three-dimensional structure of the source contributions of PM2.5 in the BTH area during this pollution episode and quantitatively assessed the effects of the emergency control measures. The results showed that during the polluted period(February 19–26), surface PM2.5 mainly originated from local sources(48%–72%). In the entire BTH area, southern Hebei(SHB) represented the largest internal contribution(33%), while the main external contributions came from Shandong(SD)(10%) and Henan(HN)(4%). Vertically, the local contribution was constrained below the near-ground layer, and rapidly decreased with altitude. The regional transport path from SHB and Shanxi(SX) to BJ appeared at 0.5–1.5 and 1.5–2.5 km, with contributions of 32%–42% and 13%–27%, respectively. The non-local source regions for the BTH area were SD below 1 km and mainly SX and HN above 1 km. Compared to the non-polluted period(February 27–28), the contribution from regional transport increased during the polluted period, indicating the key role of regional transport in the pollution formation. The emergency control measures had a relatively large effect on NOx and SO2 concentrations, but a limited effect on PM2.5. The stronger regional transport during the polluted period may have weakened the effects of the local emergency control measures. These results indicated that a coordinated emission control should be implemented not only over the BTH area but also over its surrounding provinces(e.g. SD, HN). | Huansheng Chen Jie Li Baozhu Ge Wenyi Yang Zifa Wang Si Huang Yuanlin Wang Pingzhong Yan Jianjun Li Lili Zhu | 2015 | Science China Chemistry2015，58，9： | 5 |
| 7 | The 5400 a BP extreme weakening event of the Asian summer monsoon and cultural evolution显示文摘We explored a time series of the Asian summer monsoon(ASM) variability during the transition period from the middle to the late Holocene in the marginal Asian monsoon region. We used an absolutely dated ^(230)Th record with only a ~20-year dating error, and oxygen isotope data with an 8-year average temporal resolution from the top 22-mm segment of stalagmite WXB07-4 from Wanxiang Cave, western Loess Plateau. The ASM intensity weakened gradually from 6420 to 4920 a BP, which was mainly characterized by three phases:(1) a strengthening phase with a higher precipitation amount between 6420 and 6170 a BP;(2) a smooth fluctuating interval during 6170–5700 a BP; and(3) a sudden extreme weakening period from 5700 to 4920 a BP. Interestingly, the extreme weakening interval of the ASM occurred during the period between 5700 and 4920 a BP, an abrupt change dated at 5430 a BP, which is known as the 5400 a BP, or 5.4 ka BP, event. The period included 290 years of gradual weakening, and 350 years of slow strengthening. This was synchronous with some cave records from the Asian monsoon region within dating errors. Comparing with Chinese archaeological archives over the past 7000 years, the early decline of the Yangshao Culture in the Yellow River Basin and the Hongshan Culture in the West Liao River Basin occurred during the period of gradual decrease of ASM precipitation. The dramatic decline in precipitation, caused by the extreme weakening of the ASM at 5400 a BP,may have been partly related to the decline of the Miaodigou Culture at the Yangguanzhai site in the Weihe River valley; the middle Yangshao Culture in western Henan in the Yellow River Basin; the early Dawenkou Culture on the lower reaches of the Yellow River; and the middle Hongshan Culture in the west of the Liaohe River valley. During the later period of the 5400 a BP event(5430–4920 a BP), a small amplitude increase and a subsequent sharp decrease of ASM precipitation may have also been linked to the contemporaneous prosperity and disappearance of the late Yangshao and Hongshan cultures; the disappearance of the late Yangshao Culture represented by the Yangguanzhai site in the Guanzhong basin on the Weihe River; the fourth phase of the late Yangshao Culture on the upstream Dadiwan site; the beginning of the middle Dawenkou Culture, the formation of its late stage,and the rise of the Longshan culture; and the rise of the Qujialing and Liangzhu cultures on the lower Yangtze River. Compared with the stalagmite precipitation records on the Qinghai-Tibetan Plateau, the rise and expansion of the Majiayao Culture in the upper Yellow River valley at 5300 a BP may have also been connected to the more dramatic increase of the summer monsoon precipitation at higher, rather than lower, altitudes during the late 5400 a BP event. | BAI YiJun ZHANG PingZhong GAO Tao YU RenZhe ZHOU PengChao CHENG Hai | 2017 | Science China Earth Sciences2017，60，6： | 3 |
| 8 | Third-harmonic complex cavity gyrotron self-consistent nonlinear analysis显示文摘 | Huang Yong Li Hongfu Du Pingzhong | 1997 | IEEE Trans on Plasma Science1997，25，6： | 1 |
| 9 | Game Analysis of SME Financing显示文摘 | Pingzhong Lin | 2012 | Journal of Financial Risk Management2012，，04： | 1 |
| 10 | Lipid accumulation and growth of Chlorella zofingiensis in flat plate photobioreactors outdoors显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Lu Fan | 2011 | Bioresource Technology2011，，22： | 1 |
| 11 | A 14000-year record of paleoenvironmental change in the western basin of China's third largest lake, Lake Taihu显示文摘 | Qu Wenchuan Xue Bin Dickman M D Wang Sumin Fan Chengxin Wu Ruijin Zhang Pingzhong Chen Jianfa Wu Yanhong | 2000 | Hydrobiologia2000，432，13： | 1 |
| 12 | Characterization of Chlorococcum pamirum as a potential biodiesel feedstock显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Zhongming Wang Lu Fan | 2014 | Bioresource Technology2014，，： | 1 |
| 13 | Third-harmonic complex cavity gyrotron self-consistent nonlinear analysis显示文摘 | Huang Yong Li Hongfu Du Pingzhong | 1997 | IEEE Trans on Plasma Science1997，25，6： | 1 |
| 14 | A test of climate, sun, and culture relationships from a 1810-year Chinese cave record 显示文摘 | Zhang Pingzhong Cheng Hai Edwards L | 2008 | Science2008，322，： | 1 |
| 15 | Lipid accumulation and growth characteristics of Chlorella zofingiensis under different nitrate and phosphate concentrations显示文摘 | Pingzhong Feng Zhongyang Deng Lu Fan Zhengyu Hu | 2012 | Journal of Bioscience and Bioengineering2012，，4： | 1 |
| 16 | Mercury fluxes and pools in three subtropical forested catchments, southwest China显示文摘 | Zhangwei Wang Xiaoshan Zhang Jingsong Xiao Ci Zhijia Pingzhong Yu | 2008 | Environmental Pollution2008，，3： | 1 |
| 17 | Lipid accumulation and growth of Chlorella zofingiensis in flat plate photobioreactors outdoors显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Lu Fan | 2011 | Bioresource Technology2011，，22： | 1 |
| 18 | A 14000-year record of paleoenvironmental change in the western basin of China's third largest lake,Lake Taihu显示文摘 | Xue Bin Dickman M D Wang Sunmin Fan Chengxin Wu Ruijin Zhang Pingzhong Chen Jianfa Wu Yanhong | 2000 | Hydrobiologia2000，432，13： | 1 |
| 19 | Research Progress on the Pathogenesis of Hemorrhagic Fever with Renal Syndrome显示文摘Hemorrhagic fever with renal syndrome(HFRS)is an acute natural focus epidemic disease characterized by fever,shock,hemorrhage and kidney injury caused by hantavirus infection.Hantavirus mainly infects human vascular endothelial cells,and induces extensive damage to small blood vessels and capillaries.Increased vascular permeability is the pathological basis for clinical manifestations of HFRS.Although domestic and foreign scholars have carried out many studies on the hantavirus pathogenesis,such as the immune pathological response induced by hantavirus,host genetics and apoptosis,thrombocytopenia,coagulation and fibrinolysis dysfunction,and the vascular endothelial damage,the pathogenesis of HFRS has not been fully elucidated and there is no effective drug yet.In-depth discussion of the molecular mechanism of HFRS and finding effective therapeutic drugs are still the research hotspots on the field of hantavirus/HFRS.This review will elaborate the research progress on the pathogenesis of HFRS in recent years. | Hong Du Pingzhong Wang Xuefan Bai Jing Li Xiaoyan Wang Haifeng Hu Ying Zhang Hong Jiang Huanjun Shen Jiayi Zhan Jianqi Lian | 2022 | Infectious Diseases & Immunity2022，2，4： | 1 |
| 20 | A test of climate,sun,and culture relationships from an 1810-year Chinese cave record显示文摘 | Zhang Pingzhong Cheng Hai Edwards R L | 2008 | Science2008，322，5903： | 1 |
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