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| 1 | 红霉素促进小肠动力的机制研究显示文摘近年来已有报道用红霉素治疗“胃瘫”,但对其确切的作用机制尚不十分清楚。本文对8条犬进行了小肠肌电测定,并在测定期间分别静脉滴注红霉素,阿托品+红霉素,六甲季胺十红霉素。结果发现,在静脉滴注红霉素以后,胃肠动力明显增加,但这种增加可以被阿托品或六甲季胺所抑制。结果表明,红霉素具有促进小肠动力的作用,它的这种促动力作用至少部分是由胆硷能神经参与和介导的。另外,红霉素对小肠动力的影响在不同的小肠节段是有差别的,越是近端小肠红霉素的作用越明显。 | 秦新裕 Pilot MA | 1994 | 中华消化杂志1994，14，5： | 21 |
| 2 | Amino Acid Export in Plants: A Missing Link in Nitrogen Cycling显示文摘到他们被要求的身体的部分的从来源机关的营养素的出口(例如水池机关) 是一个基本生物过程。氨基酸的出口,在植物的最丰富的氮种类之一长途的运输纸巾(即木部和韧皮部) ,是为在植物的氮的合适的分发的一个必要过程。生理的研究在植物房间膜检测了多重氨基酸出口系统的存在。然而,令人惊讶地,很少对氨基酸出口商的分子的身份被知道,部分由于技术困难妨碍出口商蛋白质的鉴定。在这短评论,我们将在植物关于氨基酸出口系统总结我们的当前的知识。几研究描述了能够的植物氨基酸 transporters 双向, facilitative 运输,更早生理的研究识别的活动暗示。而且,在可得到的氨基酸 transporter 序列的数字的最近的扩大表明了在从有很多 uncharacterized 的另外的有机体的氨基酸出口商之间的进化关系种蛋白质,其中一些可能也作为氨基酸出口商工作。另外,可以调整氨基酸的出口的基因被发现了。这些通常认为的 transporter 和管理者蛋白质的研究可以在理解帮助逃犯在植物的氨基酸出口的分子的机制。 | Sakiko Okumoto Guillaume Pilot | 2011 | Molecular Plant2011，4，3： | 13 |
| 3 | 英国大肠癌筛查预试验首轮结果显示文摘目的:评价在英国国家医疗体系(National Health Service,NHS)中推行以便隐血试验为基础的全国大肠癌筛查项目的可行性。 | UK Colorectal Cancer Screening Pilot Group 胡恩坦 | 2004 | 英国医学杂志中文版2004，7，6： | 7 |
| 4 | 口服红霉素治疗胃瘫的实验研究显示文摘实验犬8条,每次令口服一种大环内酯类抗生素,并记录其肠道动力。结果发现口服红霉素和静脉给药同样能明显增加小肠动力。两种红霉素制剂,红霉素硬脂酸和红霉素硷,都具增加小肠动力的功效;而另外两种大环内酯类抗生素,交沙霉素和螺旋霉素,却无明显的促进胃肠动力的作用。 | 秦新裕 Pilot MA | 1995 | 普外临床1995，10，2： | 6 |
| 5 | Simultaneous variable selection for heteroscedastic regression models显示文摘In this paper, we propose a new criterion, named PICa, to simultaneously select explanatory variables in the mean model and variance model in heteroscedastic linear models based on the model structure. We show that the new criterion can select the true mean model and a correct variance model with probability tending to 1 under mild conditions. Simulation studies and a real example are presented to evaluate the new criterion, and it turns out that the proposed approach performs well. | ZHANG ZhongZhan1 & WANG DaRong2 1College of Applied Sciences, Beijing University of Technology, Beijing 100124, China 2The Pilot College, Beijing University of Technology, Beijing 101101, China | 2011 | Science China Mathematics2011，54，3： | 6 |
| 6 | Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)显示文摘Depth variations of total mercury (Hg) and methylmercury (MeHg) concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh (Tagus Estuary, Portugal). Concentrations in belowground biomass exceeded up to 3 (Hg) and 15 (MeHg) times the levels in sediments, and up to 198 (Hg) and 308 (MeHg) times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution (2 cm) provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments. | Joao Canário Carlos Vale Laurier Poissant Marta Nogueira Martin Pilote Vasco Branco | 2010 | Journal of Environmental Sciences2010，22，8： | 4 |
| 7 | Predictors of itch and pain in the 12 months following burn injury:results from the Burns Registry of Australia and New Zealand(BRANZ)Long-Term Outcomes Project显示文摘Background:Itch and pain are common complaints of patients with burn injuries.This study aimed to describe the prevalence and predictors of itch and moderate to severe pain in the first 12 months following a burn injury,and determine the association between itch,moderate to severe pain,workrelated outcomes,and health-related quality of life following a burn injury.Methods:Burn patients aged 18 years and older were recruited from five Australian specialist burn units.Patients completed the 36-item Short Form Health Survey Version 2(SF-36 V2),the Sickness Impact Profile(SIP)work scale,and a specially developed questionnaire relating to itch at 1,6,and 12 months post-injury.Moderate to severe pain was defined as a score less than 40 on the bodily pain domain of the SF-36 V2.Multivariate mixed-effects regression models were used to identify patient and burn injury predictors of itch and moderate to severe pain.Results:Three hundred and twenty-eight patients were included.The prevalence of itch decreased from 50%at 1 month to 27%at 12 months.Similarly,the prevalence of moderate to severe pain decreased from 23%at 1 month to 13%at 12 months.Compared to patients aged 18-34,the adjusted odds of experiencing any itch were 59%(95%CI:0.20,0.82)and 55%(95%CI:0.22,0.91)lower for patients aged between 35 and 49 and≥50 years,respectively.Compared to patients aged 18-34,the adjusted odds of experiencing moderate to severe pain were 3.12(95%CI:1.35,7.20)and 3.42(95%CI:1.47,7.93)times higher for patients aged 35-49 and≥50 years,respectively.Conclusions:Less than 15%of patients reported moderate or severe pain at 12 months,while approximately one-quarter of the patients reported itch at the same period.The presence of moderate to severe pain was associated with a greater negative impact on health-related quality of life and work outcomes compared to itch.Further research is needed to improve our ability to identify patients at higher risk of persistent itch and pain who would benefit from targeted review and intervention studies. | Lincoln M.Tracy Dale W.Edgar Rebecca Schrale Heather Cleland Belinda J.Gabbe on behalf of the BRANZ Adult Long-Term Outcomes Pilot Project participating sites and working party | 2020 | Burns & Trauma2020，8，1： | 2 |
| 8 | Late Quaternary diatom and sea level changes in estuarine plain of the Jiulong River显示文摘Four units and twenty-four zones of diatom have been discerned in the Borehole ZK5 in the estuarine plain of the Jiulong River, Fujian Province. Comprehensive analysis of these, together with microbiological assemblages and age determinations in some other boreholes, shows that during the Late Wurm Glacial, sea level of the study area rose and fell frequently, but had principally been in the environments of estuary-bay. This mainly resulted from the tectonic subouction. In this period 3 low sea levels occurred. at 18, 16 and 12 kaBP respectively. During Holocene, sea weter intruded massively and the sea level over the transgnaion maximum had been 5-10 m higher than that of the present. | Chen Wenrui, (State Pilot Laboratory of Coast and Island Exploitation, Naning University, Naning 210093, China)Lan Dongzhao and Chen Chenghui (Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China) | 1998 | Acta Oceanologica Sinica1998，17，4： | 2 |
| 9 | Congenital Heart Disease in the General Population: Changing Prevalence and Age Distribution显示文摘 | Ariane J. Marelli Andrew S. Mackie Raluca Ionescu-Ittu Elham Rahme Louise Pilote | 2007 | Circulation2007，，2： | 2 |
| 10 | Recurrent ischemia afterthrombolysis for acute myocardial infarction显示文摘 | Pilote L Miller DP Califf RM | 2001 | Am Heart J2001，144，： | 1 |
| 11 | Regional variation across the United States in the management of acute myocardial infarction 显示文摘 | Pilote L Califf RM Sapp S etal | 1995 | N Engl J Med1995，333，9： | 1 |
| 12 | Prioritizing interventions to improve rates of thrombolysis for ischemic stroke 显示文摘 | California Acute Stroke Pilot Registry (CASPR) Investigators | 2005 | Neurology2005，64，4： | 1 |
| 13 | Mercury flux measurements in a naturally enriched area:correlation with environmental conditions during the Nevada Study and Test of the Release of Mercury From Soils显示文摘 | Poissant L Pilote M Casimir A 1999 | 1999 | J Geophys Res1999，104，21： | 1 |
| 14 | Regulated expression of Arabidopsis Shaker K+ channel genes involved in K+ uptake and distribution in the plant显示文摘 | Guillaume Pilot Frédéric Gaymard Karine Mouline Isabelle Chérel Hervé Sentenac | 2003 | Plant Molecular Biology2003，，5： | 1 |
| 15 | Spatialcontrol of actin organization at adherens junctions by asynaptotagmin-like protein Btvsz显示文摘 | PILOT F PHILIPPE J M LEMMERS C | 2006 | Nature2006，442，： | 1 |
| 16 | Identification and disruption of a plant shaker-like outward channel involved in K+ release into the xylem sap显示文摘 | GAYMARD F PILOT G LACOMBE B | 1998 | Cell1998，94，5： | 1 |
| 17 | A comprehensive view of sexspecific issues related to cardiovascular diseases显示文摘 | Pilote L Dasgupta K Guru V | 2007 | Can Med Assoc J2007，176，6： | 1 |
| 18 | A Shaker-like K+ channel with weak rectification is expressed in both source and sink phloem tissue of Arabidopsis显示文摘 | LACOMBE B PILOT G MICHARD E | 2000 | Plant Cell2000，12，： | 1 |
| 19 | Prevalence studies of GB virus-C infection using reverse transcriptase polymerase chain reaction显示文摘 | Dawson G J Schlauder G G Pilot Matias T J | 1996 | J Med Virol1996，50，： | 1 |
| 20 | A comprehensive view of sex-specific issues related to cardiovascular disease 显示文摘 | Pilote L Dasgupta K Guru V | 2007 | CMAJ2007，176，6： | 1 |
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