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| 1 | Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma:a prospective cohort study显示文摘Primary hypothyroidism commonly occurs after radiotherapy(RT),and coincides with increased circulating thyroid-stimulating hormone(TSH)levels.We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma(HL)in a prospective cohort study.From 1998 to 2001,a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL,scheduled for craniospinal irradiation and mediastinum/neck radiotherapy,respectively,underwent thyroid ultrasound and free triiodothyronine(FT3),free thyroxine(FT4),and TSH evaluation at the beginning and end of craniospinal iiradiation.From 14 days before and up to the end of radiotherapy,patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3μIU/mL.During follow-up,blood tests and ultrasound were repeated;primary hypothyroidism was considered an increased TSH level greater than normal range.Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels˂0.3μIU/mL and well matched for other variables.Twenty years on,hypothyroidism-free survival rates differed significantly,being 60%±15%and 15.6%±8.2%in TSH-suppressed vs.not-TSH suppressed patients,respectively(P=0.001).These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae,but it should be confirmed in a larger cohort. | Maura Massimino Marta Podda Lorenza Gandola Emanuele Pignoli Ettore Seregni Carlo Morosi Filippo Spreafico Andrea Ferrari Emilia Pecori Monica Terenziani | 2021 | Frontiers of Medicine2021，15，1： | 2 |
| 2 | lntimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，： | 1 |
| 3 | Intimal puls medial thickness of the arterial wall:a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoci E Poli A | 1986 | Circulation1986，74，6： | 1 |
| 4 | Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging显示文摘 | Paolo Pignoli Elena Tremoli Andrea Poli Pierluigi Oreste Rodolfo Paoletti | 1986 | Circulation1986，，6： | 1 |
| 5 | Intima Plus medial thickness of the arterial wall: a direct Measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poll A | 1986 | Circulation1986，，： | 1 |
| 6 | Intimal plus medial thickness of the arterial wall:A direct rneasurernent with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，： | 1 |
| 7 | Intima plus media thickness of the arterialwall:a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，2： | 1 |
| 8 | Intimal plus medial thickness of the arterial wall:a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，6： | 1 |
| 9 | Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging 显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，： | 1 |
| 10 | Intimal plus medial thickness of the arteiral wall:a direct measurement with ultrasound imagine显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，： | 1 |
| 11 | Intinal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，6： | 1 |
| 12 | Intimalplusmedial thickness of the arterial wall: a direct measurement with ultrasound imaging 显示文摘 | Pignoli P Tremoli E Oreste P | 1986 | Circulation1986，74，： | 1 |
| 13 | lntimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging 显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circulation1986，74，6： | 1 |
| 14 | Intimal plus media thickness of the arterial wall:A direct measorement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Poli A | 1986 | Circolation1986，74，6： | 1 |
| 15 | Intimalplusmedial thickness of the arterial wall: a direct measurement with ultrasound imaging 显示文摘 | Pignoli P Tremoli E Oreste P | 1986 | Circulation1986，74，6： | 1 |
| 16 | Ultrasound B --mode imaging for arterial wall thick- hess measurement显示文摘 | Pignoli P | 1984 | Atheroseler Rew1984，12，： | 1 |
| 17 | Intimal plus medial thickness of the arterial wall a diret measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Oreste P | 1986 | Circulation1986，74，： | 1 |
| 18 | Mode imaging for arterial wall thickness measurement显示文摘 | Pignoli P Ultrasound B | 1984 | Atheroscler Rew1984，12，2： | 1 |
| 19 | Intimal Plus medial thickness of the arterial wall:a direct measurement with ultrasound imaging显示文摘 | Pignoli P Tremoli E Oreste P | 1986 | Circulation1986，74，： | 1 |
| 20 | Ultrasound B-mode imaging for arterial wall thickness measurement显示文摘 | Pignoli P | 1984 | Atheroscler Rev1984，12，： | 1 |
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