3篇
您的检索式：作者名="Pietro Ferrara"
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| 1 | Increased levels of neurotrophins in the cerebrospinal fluid of children with Epstein–Barr virus meningoencephalitis显示文摘 | Antonio Chiaretti Domenico Capozzi Paolo Mariotti Piero Valentini Luigi Manni Danilo Buonsenso Claudia Fantacci Pietro Ferrara | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 2 | Antialgal compounds from zantedeschia aethiopica显示文摘 | Marina Della Greca Maria Ferrara Antonio Fiorentino Pietro Monaco Lucio Previtera | 1998 | Phytochemistry1998，，5： | 1 |
| 3 | Clinical spectrum and currently available treatment of typeⅠinterferonopathy Aicardi-Goutières syndrome显示文摘Background Aicardi-Goutières syndrome(AGS)is a genetically determined disorder with a variable phenotype.Since the original description of AGS,advances in gene sequencing techniques have resulted in a significant broadening of the phenotypic spectrum associated with AGS genes,and new clinical pictures have emerged beyond the classic presentation.The aim of this review is to provide a comprehensive analysis of the clinical spectrum of AGS and report currently available treatments and new immunosuppressive strategies.Data sources Literature reviews and original research articles were collected from databases,including PubMed and Clini-calTrials.gov.Relevant articles about AGS were included.Results The involvement of the nervous system certainly represents the major cause of mortality and morbidity in AGS patients.However,other clinical manifestations,such as chilblains,hepatosplenomegaly,and hematological disturbances,may lead to the diagnosis and considerably impact the prognosis and overall quality of life of these patients.Therapeutic approaches of AGS are limited to interventions aimed at specific symptoms and the management of multiple comorbidities.However,advances in understanding the pathogenesis of AGS could open new and more effective therapies.Conclusions The over-activation of innate immunity due to upregulated interferon production plays a critical role in AGS,leading to multi-organ damage with the main involvement of the central nervous system.To date,there is no specific and effective treatment for AGS.New drugs specifically targeting the interferon pathway may bring new hope to AGS patients. | Giovanni Battista Dell'Isola Gianluca Dini Kaleb Logan Culpepper Katherin Elizabeth Portwood Pietro Ferrara Giuseppe Di Cara Alberto Verrotti Mauro Lodolo | 2023 | World Journal of Pediatrics2023，19，7： | 0 |
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