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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Is there a relationship between dopamine and rhegmatogenous retinal detachment?显示文摘Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Ver gata University Hospital(R.S.92.10) on September 24, 2010. | Alessio Martucci Massimo Cesareo Maria Dolores Pinazo-Durán Michela Di Pierro Matteo Di Marino Carlo Nucci Massimiliano Coletta Raffaele Mancino | 2020 | Neural Regeneration Research2020，15，2： | 2 |
| 4 | Early elevation of interleukin-1β and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina显示文摘 | Gennaro Sardella Paola Mariani Mariadomenica D’Alessandro Leonardo De Luca Marianna Pierro Massimo Mancone Alessandro Porretta Daniele Accapezzato Francesco Fedele Marino Paroli | 2005 | Thrombosis Research2005，，6： | 2 |
| 5 | Thermal bridging of graphene nanosheets via covalent molecular junctions: A non-equilibrium Green's functions-density functional tightbinding study显示文摘Despite the uniquely high thermal conductivity of graphene is well known,the exploitation of graphene into thermally conductive nanomaterials and devices is limited by the inefficiency of thermal contacts between the individual nanosheets.A fascinating yet experimentally challenging route to enhance thermal conductance at contacts between graphene nanosheets is through molecular junctions,allowing covalently connecting nanosheets,otherwise interacting only via weak Van der Waals forces.Beside the bare existence of covalent connections,the choice of molecular structures to be used as thermal junctions should be guided by their vibrational properties,in terms of phonon transfer through the molecular junction.In this paper,density functional tight-binding combined with Green's functions formalism was applied for the calculation of thermal conductance and phonon spectra of several different aliphatic and aromatic molecular junctions between graphene nanosheets.Effects of molecular junction length,conformation,and aromaticity were studied in detail and correlated with phonon tunnelling spectra.The theoretical insight provided by this work can guide future experimental studies to select suitable molecular junctions,in order to enhance the thermal transport by suppressing the interfacial thermal resistances.This is attractive for various systems,including graphene nanopapers and graphene polymer nanocomposites,as well as related devices.In a broader view,the possibility to design molecular junctions to control phonon transport currently appears as an efficient way to produce phononic devices and controlling heat management in nanostructures. | Diego Martinez Gutierrez Alessa ndro Di Pierro Alessa ndro Pecchia Leon ardo Medra no San donas Rafael Gutierrez Mar Bernal Bohayra Mortazavi Gianaurelio Cuniberti Guido Saracco Alberto Fina | 2019 | Nano Research2019，12，4： | 2 |
| 6 | Urinary intestinal fatty acid - binding protein concentration predicts extent of disease in neerotizing enterocolitis 显示文摘 | Evennett N J Hall N J Pierro A | 2010 | J Pediatr Surg2010，45，4： | 1 |
| 7 | Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy显示文摘 | Arif H Buchsbaum R Pierro J | 2010 | Arch Neurol2010，67，4： | 1 |
| 8 | Intestinal ischemia reperfusion injury and multisystem organ failure 显示文摘 | Pierro A Eaton S | 2004 | Semi Pediatr Surg2004，13，1： | 1 |
| 9 | Charismatic Leadership andOrganizational Outcomes: The Mediating Role of Em- ployees~ Work-Group Identification显示文摘 | CICERO L PIERRO A | 2007 | International Journal of Psychology2007，42，5： | 1 |
| 10 | Preparation and mechanical properties of edible pectin-soy flour films obtained in the absence or presence of transglutminase显示文摘 | Mariniello L Pierro P D Esposito C | 2003 | J Biotechnol2003，102，： | 1 |
| 11 | Chitosan-whey protein edible films produced in the absence or presence of transglutaminase:Analysis of their mechanical and barrier properties显示文摘 | PROSPERO DI PIERRO BELKIS CHICO REYNALDO VILLALONGA | 2006 | Biomacromolecules2006，7，3： | 1 |
| 12 | Continuous enteral feeding impairs gallbladder emptying in infants显示文摘 | Shaw N Pierro A | 2001 | J Pediatr2001，138，6： | 1 |
| 13 | Nasal continuous positive airway pressure with heliox in preterm infants with respiratory distress syndrome显示文摘 | Colnaghi M Pierro M Migliori C | 2012 | Pediatrics2012，129，2： | 1 |
| 14 | Intestinal ischemia reperfusion injury and multisystem organ failure显示文摘 | Agostino Pierro Simon Eaton | 2004 | Seminars in Pediatric Surgery2004，，1： | 1 |
| 15 | Axial length in patients with diabetes 显示文摘 | Pierro L Brancato R Robino X | 1999 | Retina1999，19，5： | 1 |
| 16 | Gall bladder contractility in neonates:effects of parenteral and enteral feeding显示文摘 | Pierro A Lloyd D Shaw N | 1995 | Arch Dis Child1995，72，3： | 1 |
| 17 | Preparation and mechanical properties of edible protein soy flour films obtained in the absence or presence of transglutaminase 显示文摘 | Mariniello L Pierro P D Esprosito C | 2003 | Journal of Biotechnology2003，102，： | 1 |
| 18 | Treatment of lumbar spinal stenosis by extensive unilateral decompression and contralateral autologous bone fusion:operative technique and results显示文摘 | Helm GA Shaffrey CI | 1996 | J Neurosurg1996，84，2： | 1 |
| 19 | Axial length in patients with diabetes显示文摘 | Pierro L Brancato R Robino X | 1999 | Retina1999，19，： | 1 |
| 20 | Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK- 53), axe defined by mutations in the 5' noneoding region and nonstructural proteins 1 and 3显示文摘 | Butrapet S Huang CY Pierro DJ | 2000 | Virol2000，74，： | 1 |
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