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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Urinary intestinal fatty acid - binding protein concentration predicts extent of disease in neerotizing enterocolitis 显示文摘 | Evennett N J Hall N J Pierro A | 2010 | J Pediatr Surg2010，45，4： | 1 |
| 4 | Intestinal ischemia reperfusion injury and multisystem organ failure 显示文摘 | Pierro A Eaton S | 2004 | Semi Pediatr Surg2004，13，1： | 1 |
| 5 | Charismatic Leadership andOrganizational Outcomes: The Mediating Role of Em- ployees~ Work-Group Identification显示文摘 | CICERO L PIERRO A | 2007 | International Journal of Psychology2007，42，5： | 1 |
| 6 | Continuous enteral feeding impairs gallbladder emptying in infants显示文摘 | Shaw N Pierro A | 2001 | J Pediatr2001，138，6： | 1 |
| 7 | Gall bladder contractility in neonates:effects of parenteral and enteral feeding显示文摘 | Pierro A Lloyd D Shaw N | 1995 | Arch Dis Child1995，72，3： | 1 |
| 8 | Gall bladder contractility in neonates: effects of parenteral and enteral feeding显示文摘 | Jawaheer G Pierro A Lloyd D A | 1995 | Archiv- es of Disease in Childhood-Fetal and Neonatal Edition1995，72，3： | 1 |
| 9 | Age-related probability of contralateral processus vaginalis patency in children with unilateral inguinal hernia显示文摘 | Hall NJ Choi W Pierro A | 2012 | Pediatr Surg Int2012，28，11： | 1 |
| 10 | When similarity breeds content:Need for closure and the allure of homogeneous and self-resembling groups显示文摘 | Kruglanski A W Shah J Y Pierro A Mannetti L | | 0，，83： | 1 |
| 11 | Pediatric laparoscopic-assisted gastric transposition:early experience and outcomes显示文摘 | Stanwell J Drake D Pierro A | 2010 | J Laparoendosc Adv Surg Tech A2010，20，2： | 1 |
| 12 | In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (PolinaceaTM)显示文摘 | MORAZZONI P CRISTONI A DI PIERRO F | 2005 | Fitoterapia2005，76，： | 1 |
| 13 | Laparoscopy assists surgical decision making in infants with necrotizing enterocolitis显示文摘 | Pierro A Hall N Ade-Ajayi A | 2004 | J Pediatr Surg2004，39，6： | 1 |
| 14 | Chitosan/whey protein film as active coating to extend ricotta cheese shelf-life 显示文摘 | Pierro P D Sorrentino A Mariniello L | 2011 | LWT-Food Science and Technology2011，44，10： | 1 |
| 15 | Clinical application of a molecular method based on real time RT-PCR for detection of influenza A(H1N1)v virus显示文摘 | Pierro A Gaibani P Rossini G | 2013 | New Microbiol2013，36，4： | 1 |
| 16 | Neonatal endotoxemia affects heart but not kidney bioenergetics显示文摘 | Fukumoto K Pierro A Spitz L | 2003 | J Pediatr Surg2003，38，5： | 1 |
| 17 | Outcome and complications after resection of hepatoblastoma 显示文摘 | Towu E Kiely E Pierro A Spitz L | 2004 | J Pediatr Surg2004，39，2： | 1 |
| 18 | Gastric transposition in children-a 21-year experience显示文摘 | Spitz L Kiely E Pierro A | 2004 | J Pediatr Surg2004，39，3： | 1 |
| 19 | Reverse order law for reflexive generalized inverses of products of matrices显示文摘 | De Pierro A R Wei M S | 1998 | Linear Algebra and Its Applications1998，277，： | 1 |
| 20 | Urinary intestinal fatty acid-binding protein concentration predicts extent of disease in necrotizing enterocolitis 显示文摘 | Evennett NJ Hall N J Pierro A | 2010 | J Pediatr Surg2010，45，4： | 1 |
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