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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Nasal continuous positive airway pressure with heliox in preterm infants with respiratory distress syndrome显示文摘 | Colnaghi M Pierro M Migliori C | 2012 | Pediatrics2012，129，2： | 1 |
| 3 | Nasal continuous positive airway pressure with heliox in preterm infants with respiratory distress syndrome显示文摘 | Colnaghi M Pierro M Migliori C | | 0，，2： | 1 |
| 4 | Pneumonia in a cardiothoracic intensive care unit: incidence and risk factors 显示文摘 | MASTRO PIERRO R BETTINZOLI M BORDONALI T | 2009 | J Cardiothorac Vasc Anesth2009，23，6： | 1 |
| 5 | A point mutation affecting an SP1 binding site in the promoter of the ferrochelatase gene impairs gene transcription and causes erythropoietic protoporphyria显示文摘 | Di Pierro E Cappellini M D Mazzucchelli R | 2005 | Exp Hematol2005，33，5： | 1 |
| 6 | Reverse order law for reflexive generalized inverses of products of matrices显示文摘 | De Pierro A R Wei M S | 1998 | Linear Algebra and Its Applications1998，277，： | 1 |
| 7 | Reverse order law for reflexive generalized inverse of products of matrices显示文摘 | PIERRO A R De WEI M | 1998 | Linear Algebra Appl1998，277，： | 1 |
| 8 | Drinking habits of subjects with hepatitis C virus related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects显示文摘 | LOGUERCIO C DI PIERRO M DI MARINO MP | 2000 | Alcohol2000，35，： | 1 |
| 9 | Role of ganglion cell complex in visual recovery following surgical internal limiting membrane peeling显示文摘 | Pierro L Iuliano L Gagliardi M | 2015 | Graefes Arch Clin Exp Ophthahnol2015，253，1： | 1 |
| 10 | Early elevation of interleukin - 1 beta and interleukin - 6 levels after bare or drug - eluting stent implantation in patients with stable angina显示文摘 | Sardella G Mariani P DAlessandro M De Luca L Pierro M Mancone M Porretta A Aceapezzato D Fedele F Paroli M | 2006 | Thmmb Res2006，117，6： | 1 |
| 11 | Reverse order law for reflexive generalized inverse of products of matrices显示文摘 | De PIERRO A R WEI M | 1998 | Linear Algebra Appl1998，277，： | 1 |
| 12 | Peripheral retinal changes and axial myopia 显示文摘 | PIERRO L CAMESASCA FI MISCHI M | 1992 | Retin1992，12，1： | 1 |
| 13 | Fast EM-like methods for maximum a posteriori estimates in emission tomography显示文摘 | DE PIERRO A R YAMAGISHI M E B | 2001 | IEEE Transactions on Medical Imaging2001，20，4： | 1 |
| 14 | Perturbation analysis of the canonical subspace显示文摘 | Wei M De Pierro A R | 1980 | Linear Algebra Appl1980，279，： | 1 |
| 15 | Drinking habits of subjects with hepatitis C virus-related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects 显示文摘 | Loguercio C Di Pierro M Di Marino M P | 2000 | Alcohol Alcohol2000，35，： | 1 |
| 16 | Excited heavy-light systems and hadronic Transitions显示文摘 | PIERRO M D EICHTEN E | 2001 | Phys Rev D2001，64，11： | 1 |
| 17 | Upper perturbation bounds of weighted projections, weighted and constrained least squares problems显示文摘 | WEI M DE PIERRO A R | 2000 | SIAM J Matrix Anal Appl2000，21，3： | 1 |
| 18 | Ultrasound biomicroscopy following the intraocular use of silicone oil显示文摘 | Azzolini C Pierro L Codenotti M | 1995 | Int Ophthalmol1995，19，： | 1 |
| 19 | Reverse order law for reflexive generalized inverses of products of matrices显示文摘 | Pierro A R De Wei M | 1998 | Lin Alg Appl1998，277，： | 1 |
| 20 | Revere order law for reflexive generalized inverses for products of matrices显示文摘 | De Pierro A R Wei M | 1998 | Lin Alg Appl1998，277，： | 1 |
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