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42篇 您的检索式:作者名="Pierre JM"
    题名 作者 年代 出处 被引量
1核糖体失活蛋白及其在黄瓜中的表达分析(英文)显示文摘核糖体失活蛋白是一类具有高度特异性r RNA N-糖苷酶活性的蛋白,它们能够使原核或真核细胞的核糖体失活因而具有细胞毒性.由于其独特的生物学性质,核糖体失活蛋白被认为在农业和医学中都有着巨大的应用潜力.我们之前的研究表明,黄瓜的基因组中共包含2个2类核糖体失活蛋白基因,分别命名为Cumsa AB1和Cumsa AB2.以蓖麻毒蛋白Ricin为代表,2类核糖体失活蛋白通常由2条二硫键连接的肽链组成:具有N-糖苷酶活性的A链与具有凝集素活性的B链.本文研究了黄瓜中核糖体失活蛋白的表达情况.亚细胞定位研究表明Cumsa AB1经过蛋白分泌通路表达于细胞外,这与蛋白质序列分析显示的Cumsa AB1包含一个信号肽而不含转膜区域相一致.对黄瓜的不同生长阶段的不同组织中的转录水平分析表明,Cumsa AB1在大部分组织中以极低的水平表达,而Cumsa AB2表达水平则明显更高,尤其在第一片真叶阶段和刚开花的植物中.最后,我们使用分子模拟对黄瓜中核糖体失活蛋白的结构及糖结合位点进行了分析.本研究对黄瓜中核糖体失活蛋白的亚细胞定位、表达水平和可能的蛋白质结构进行了研究,为其进一步的生物学功能研究提供了重要信息.党刘毅 Pierre Rougé Els JM Van Damme 2017生物化学与生物物理进展2017,44,10:2
2Understanding the new and evolving profile of adverse drug effects in schizophrenia显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,1:1
3Undersatanging the new and evolving profile of adverse drug effects in schizophrenia显示文摘 Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,1:1
4Risperidone-associated new-onset diab-etes 显示文摘Wirshing DA Pierre JM Eyeler J 2001Biol Psychiatry2001,50,4:1
5Behavioral in- terventions for antipsychotic medication-associated obesi- ty: a randomized, controlled clinical trial 显示文摘Eriekson ZD Mena SJ Pierre JM 2016J Clin Psychiatry2016,77,2:1
6Risperidone-associated new-onset diabetes显示文摘Wirshing DA Pierre JM Eyeler J 2001Biol Psychiatry2001,50,:1
7Tardive dyskinesia and serum Iron indices显示文摘Wirshing DA Bartzokis G Pierre JM 1998Biol Psychiatry1998,44,6:1
8Inhibition of Na-K- atpase by external electrical cardioversion in a sheep model of atrial fibrillation显示文摘Maixent JM Barbey O Pierre S 2000J Cardiovase Electrophysiol2000,11,4:1
9Understanding the new and evolving profile of adverse drug effects in schizophrenia显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,1:1
10Understanding the new and evolving profile of adverse drug effects in schizophrenia显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat clin North Am2003,26,1:1
11Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes 显示文摘Aristoteles G Pierre F Ghulam JM 2008Ann Hematol2008,87,5:1
12Understanding the new and evolving profile of adverse drug effects in schizophrenia 显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,:1
13Chromosome Aberrations in perip heral blood lymphocyte of characanrization of their exposure by biology samples analysis显示文摘 Mur JM Pierre F 1989J Occup Med1989,31,:1
14Understanding the new and evolving profile of adverse drug effects in schizophrenia显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat clin North Am2003,26,1:1
15Decreased mi-crovascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance显示文摘Newman JM Dwyer RM St Pierre P 2009J Physiol2009,587,11:1
16Risperidone-associa tednew-onsetdiabetes显示文摘Wirshing DA Pierre JM Eyeler J 2001BiolPsychiatry2001,50,:1
17Understanding the new and evolving prefile of adverse drug effects in schizophrenia显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,1:1
18Risperidone-associated new-onset diabetes 显示文摘Wirshing DA Pierre JM Eyeler J 2001Biol Psychiatry2001,50,:1
19Benztropine for venlafaxine-induced night sweats显示文摘Pierre JM Guze BH 2000J Clin Psychopharmacol2000,20,2:1
20Understanding the new and evolving profile of adverse drag effects in schizophrenia 显示文摘Wirshing DA Pierre JM Erhart SM 2003Psychiat Clin North Am2003,26,1:1
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