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| 1 | 自发性脑出血管理指南 美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索,检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见,采用美国心脏协会/美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南,重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。 | J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung Joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆 徐欣 | 2015 | 国际脑血管病杂志2015，23，10： | 444 |
| 2 | Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner显示文摘AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain reaction.OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines.OPN expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture.Huh-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth.Expression of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and immunohistochemistry.RESULTS:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B and-C.OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue.Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium.Transfer of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner.Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect.OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative effect.CONCLUSION:This study demonstrates that OPN plays a significant role in the proliferation of HCC through interaction with the cell surface receptor CD44.Modulation of this interaction could represent a novel strategy for the control of HCC. | Renee J Phillips Karla J Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard | 2012 | World Journal of Gastroenterology2012，18，26： | 12 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | 如何建立合理有效的重症监护病房显示文摘ICU正迅速成为现代医院运行的核心。在美国,ICU床位虽然只占医院病床的5%左右,但ICU患者的住院费用却占医院总医疗消费的30%以上,而且ICU平均病死率为30%,是所有住院患者的10倍。随着人口老龄化与住院患者结构越来越偏向病情较严重者,未来ICU床位需求势必进一步增加。因此,ICU的建设与管理无论从医疗还是经营角度上讲都非常重要。目前世界各地ICU组织管理模式差异很大,本文从多个方面系统地介绍美国ICU系统,期望为国内同行开展ICU工作提供借鉴。 | 乔人立 Phillip H Factor | 2013 | 中华结核和呼吸杂志2013，36，6： | 4 |
| 5 | Dairy food consumption and body weight and fatness studied longitudinally over the adolescent period显示文摘 | PHILLIPS S M BANDINI L G CYR H | 2003 | International Journal of Obesity2003，27，： | 2 |
| 6 | Airbome laser hydrography in Australia 显示文摘 | PENNY M F ABBOT R H PHILLIPS D M | 1986 | App Opt1986，25，13： | 2 |
| 7 | Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants显示文摘 | Ocky K. Radjasa Yvette M. Vaske Gabriel Navarro Hélène C. Vervoort Karen Tenney Roger G. Linington Phillip Crews | 2011 | Bioorganic & Medicinal Chemistry2011，，22： | 2 |
| 8 | The unchanging pattern of subarachnoid hemorrhage in a community显示文摘 | Phillips L H | 1980 | Neurology1980，30，10： | 1 |
| 9 | A new aluminum hydroxide octamer (SO4)5 · 16H2O显示文摘 | Casey W H Olmstead M M Phillips B L | 2005 | Inorg Chem2005，44，： | 1 |
| 10 | The FERET evaluation methodology for face-recognition algorithms显示文摘 | PHILLIPS P J MOON H RIZVI S A | 2000 | IEEE Transactions on PAM12000，22，10： | 1 |
| 11 | Rock excavation by disc cutter显示文摘 | ROXBOROUGH F F PHILLIPS H | 1975 | International Journal of Rock Mechanics and Mining Sciences1975，12，12： | 1 |
| 12 | Correlation of travel time on roads versus straight-line distance显示文摘 | Phillips C S Luft H S | 1995 | Medicare Research and Review1995，52，4： | 1 |
| 13 | Rock excavation by disccnt- ter显示文摘 | Roxborough F F Phillips H R | 1975 | International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts1975，12，12： | 1 |
| 14 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 15 | New techniques for the treatment of com- mon bile ductcalculi encountered during lapm'oscopic cholecystectomy显示文摘 | PHILLIP E H | 1991 | Probl Gen Surg1991，8，6： | 1 |
| 16 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 17 | The role of potassium in muscle phosphorylations 显示文摘 | BOYER P D LARDY H A PHILLIPS P H | 1942 | Joumal of Biological Chemistry1942，146，： | 1 |
| 18 | Fatigue-life prediction methodology using small crack theory显示文摘 | Newman J C Jr Phillips E P Swain M H | 1999 | International Journal of Fatigue1999，21，2： | 1 |
| 19 | Cellular Structure of Peanut-based Extruded Snack Products Using Scanning Electron Microscopy显示文摘 | I D Choi R D Phillips H S Jeong | 2004 | Jonrnal of Texture Studies2004，35，： | 1 |
| 20 | Distribution of uranium contamination in weathered fractured saprolite/shale and ground water显示文摘 | Phillips D H Watson D B Roh Y 2006 | 2006 | Journal of Environmental Quality2006，35，5： | 1 |
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