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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | 上颌窦癌的术后放疗显示文摘副鼻窦癌在美国很少见,年发病率约为1/100000。由于发病隐匿,在诊断时往往已到中晚期。而副鼻窦又邻近重要器官,如眼眶、颅底、脑,彻底的肿瘤切除较为困难,满意的放疗设计也受到限制。所以,中晚期副鼻窦癌的治疗十分棘手。本文是回顾性分析,着重研究上颌窦癌的术后放疗。 | 蒋国樑 Ang KK Peters JL wendt CD Oswald MJ Ceopfer TH | 1991 | 中华放射肿瘤学杂志1991，0，3： | 5 |
| 4 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 5 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 6 | 介入性肺脏病学在早期非小细胞肺癌诊断及治疗中的应用显示文摘肺癌的治疗非常复杂,需要多学科联合来提供综合治疗。介入性肺脏病学是利用微创的方式为疑似肺癌的患者进行初步诊断和分期,在目前仍是一个不断发展的学科领域。支气管超声引导下的对纵隔淋巴结采样进行分期,同时进行驱动突变检测是早期和晚期肺癌诊断及治疗的重要工具,支气管超声引导下支气管镜的进步使得可疑周围性病变的组织学采样的并发症发生率大大降低同时为立体定向放疗植入基准标记。此外,介入性肺脏病学可以缓解不可手术的癌症及晚期癌症。由于低剂量CT扫描用于肺癌的早期发现,对肺部结节的治疗有经验的肺病专科医师来说,最重要的是尽可能减少侵袭性采样,整合多学科诊治的模式进行分期。 | Ryu Peter Hambrook Tofts Peter MJ Lee Arthur Wai Sung 谭文勇 | 2015 | 中国胸心血管外科临床杂志2015，22，4： | 2 |
| 7 | CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation显示文摘 | Inwald DP McDowall A Peters MJ | 2003 | Cir Res2003，92，9： | 1 |
| 8 | Treatment of ac-quired esotropia:for augmented surgery显示文摘 | Greenwald MJ Eagle JR Peters C | | 0，，： | 1 |
| 9 | Reduced IL-4 and inter- feron-gamma (IFN-7) expression by CD4 T cells in patients with chronic lymphocytic leukemia显示文摘 | Hill SJ Peters SH Ayliffe MJ | 1999 | Clin Exp Immunol1999，117，1： | 1 |
| 10 | The pharmacotherapy of smoking cessation显示文摘 | Peters MJ Morgan LC | 2002 | Med J Aust2002，176，10： | 1 |
| 11 | EULAR evidence-basedrecommendations for cardiovascular risk management in patientswith rheumatoid arthritis and other forms of inflammatory arthritis显示文摘 | Peters MJ Symmons DP McCarey D | 2010 | Ann Rheum Dis2010，69，2： | 1 |
| 12 | Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease?A prospective study显示文摘 | Peters MJ van Halm VP Voskuyl AE | 2009 | Arthritis Rheum2009，61，： | 1 |
| 13 | Glutathione S- transferases ia gastric carcinomas and in adjacent normal gastric epithelium: immunohistochemical and biochemical analyses 显示文摘 | Schipper DI Wagenmans MJ Peters WH | 1996 | Anticancer Res1996，16，6： | 1 |
| 14 | Outcomes of an Australian testing programme for epidermal growth factor receptor mutations in non-small cell lung cancer显示文摘 | Peters MJ Bowden JJ Carpenter P | 2014 | Intern Med J2014，44，6： | 1 |
| 15 | Transforming growth factor beta signal transduction显示文摘 | Dennler S Goumans MJ Peter TD | 2002 | J Leukoc Biol2002，71，5： | 1 |
| 16 | Viral hepatitis in HIV infection显示文摘 | Koziel MJ Peters MG | 2007 | N Engl J Med2007，356，14： | 1 |
| 17 | Hemodynamics ofearly pediatric fluid-resistant septic shock using non-in-vasive cardiac output (USC0M) :distinct profiles of CVCinfection and community acquired sepsis 显示文摘 | Brierley J Thiruchelvam T Peters MJ | 2006 | Crit CareMed2006，33，12： | 1 |
| 18 | An investigation of perceived risk at the brand level显示文摘 | Peter JP Ryan MJ | 1976 | Journal of Marketing Research1976，13，： | 1 |
| 19 | Disstinction between IL - 13 + and IFN - γ + natural killer cells and regulation of their pool size by IL - 4 显示文摘 | Loza MJ Peters SP Zangrilli JG | 2002 | Eur J Immunol2002，32，2： | 1 |
| 20 | CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation 显示文摘 | Inwaid DP McdowaU A Peters MJ | 2003 | Circ Res2003，92，9： | 1 |
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