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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease显示文摘AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAM use across all cohorts. METHODS: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAM use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAM use were determined using binary logistic regression analysis. RESULTS: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAM use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAM use to their doctor. Independent predictors of CAM use which confirm those reported previously were: covert conventional medication dose reduction(P < 0.001), seeking psychological treatment(P < 0.001), adverse effects of conventional medication(P = 0.043), and higher QOL(P < 0.001).Newly identified predictors were CAM use by family or friends(P < 0.001), dissatisfaction with patient-doctor communication(P < 0.001), and lower depression scores(P < 0.001). CONCLUSION: In addition to previously identified predictors of CAM use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAM use. Patient reluctance to discuss CAM with physicians may promote greater reliance on social contacts to influence CAM decisions. | Réme Mountifield Jane M Andrews Antonina Mikocka-Walus Peter Bampton | 2015 | World Journal of Gastroenterology2015，21，12： | 6 |
| 3 | It IS worth the effort: Patient Knowledge of Reproductive Aspects of Inflammatory Bowel Disease Improves Dramatically After a Single Group Education Session显示文摘 | Réme Mountifield Jane M. Andrews Peter Bampton | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 4 | Advance in apoptosis research显示文摘 | Hengartner MO | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 5 | Advances in apoptosis re- search 显示文摘 | Peter ME Heufelder AE Hengartner MO | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 6 | Advances in apopto is research显示文摘 | Peter ME Hedelder AE Hengarmer MO | 1997 | Proc Natl Acad Sci U S A1997，94，24： | 1 |
| 7 | Basic mechanical properties of retina in simple elongation显示文摘 | Wu W Peters WH 3rd Hammer ME | 1987 | Biomech Eng1987，109，1： | 1 |
| 8 | The CD95 (APO21/ Fas) DISC and beyond 显示文摘 | Peter ME Krammer PH | 2003 | Cell Death Differ2003，10，： | 1 |
| 9 | 显示文摘 | Peter JB Gershwin ME | 2000 | J Hepatol2000，32，2： | 1 |
| 10 | Serum autoantibodies in patients with primary sclerosing cholangitis显示文摘 | Angulo P Peter JB Gershwin ME | 2000 | J Hepatol2000，32，2： | 1 |
| 11 | Advances in apoptosis lymphocytes from nitrogen mustard-induced apoptosis显示文摘 | Peter ME Heuffllder AE Hengartner MO | 1998 | Biochem Pharamacol1998，51，9： | 1 |
| 12 | Estrogen-progestin replacement therapy and endometrial cancer 显示文摘 | Pike ME Peters RK Cozen W | 1997 | J Natl Cancer Inst1997，89，： | 1 |
| 13 | Widespread occurrence of integrons causing multiple antibiotic resistance in bacteria显示文摘 | Jones ME Peters E Weersink A-M | 1997 | Lancet1997，349，9067： | 1 |
| 14 | The CD95 (AP0-1/Fas) DISC and beyond 显示文摘 | Peter ME Krammer PH | 2003 | Cell Death Differ2003，10，1： | 1 |
| 15 | Advances inapoptosis research显示文摘 | Peter ME Heufelder AE Hengartner MD | 1997 | Proc Natl Acad Sci1997，94，12： | 1 |
| 16 | Distributed Crack analysis of ceranic inlay 显示文摘 | Peters Me de vree JH Brekel manswA | 1993 | Dent Res1993，72，： | 1 |
| 17 | Engineering and characterization of functional human microvessels in im- munodeficient mice显示文摘 | Nor JE Peters Me Christensen JB | 2001 | Lab Invest2001，81，： | 1 |
| 18 | Urokinase-type plasminogen activator system in breast cancer:association with tamoxifen therapy in recurrent disease显示文摘 | Meijer-van Gelder ME Look MP Peters HA | 2004 | Cancer Res2004，64，13： | 1 |
| 19 | Immunologyand the liver显示文摘 | Peters M Vierling J Gershwin ME | 1990 | Hepatology1990，13，： | 1 |
| 20 | Programmed cell death:Apoptosis meets necrosis显示文摘 | Peter ME | | 0，，7338： | 1 |
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