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| 1 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 2 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | 座椅热舒适性客观评价温度模型构建显示文摘本文建立了人体—座椅接触面的温度模型,利用实测温度数据验证了模型的精度。从接触面温度特性模型中提取出了三个评价指标:接触面最终温度,接触面温度的最大变化率以及接触面的平均温度,据此建立了座椅舒适度客观评价体系。利用评价体系对三种材料座椅(泡沫、压模和木质座椅)进行评估,结果表明:泡沫座椅的舒适度得分为8.96±2.58,压模座椅的舒适度得分为6.15±1.96,木质座椅的舒适度得分为4.91±1.88。主观测评法得到的座椅舒适度得分为:泡沫座椅的舒适度得分为8.36±1.21,压模座椅的舒适度得分为7.27±1.42,木质座椅的舒适度得分为5.36±3.14。结论,利用人体—座椅接触面温度特性来衡量座椅舒适度的客观评价体系具有一定的实用性和可靠性。 | 刘卓夫 李恩会 李峻夫 Cascioli Vincenzo Heusch I Andrew McCarthy W Peter | 2012 | 人类工效学2012，18，1： | 5 |
| 5 | 应用探地雷达方法对海南岛博鳌海岸沙坝的研究显示文摘了解海岸沙坝的内部结构对于动态地恢复海岸沙坝与海平面变化的相互关系具有重要的意义 ,探地雷达 (GPR)为海岸沙坝的研究提供了一种快速、经济和高分辨率的地球物理方法 ;探地雷达利用高频电磁波在介电特性不均匀的沉积体中产生反射获得图像 ,通过解译可确定地下沉积体的性质和结构 ;在海南岛东部博鳌玉带滩海岸沙坝的近口门处、决口堤处和南岗村东侧玉带滩海岸沙坝顶部进行了探地雷达反射剖面的测量 ;研究结果表明自然堆积的沙体反射波连续 ,受风暴浪改造的沙体同相轴错断 ,反射波杂乱不连续 ,无法进行对比 ;运用探地雷达相分析方法并结合钻孔资料 ,认为 5~ 6 m以上的平行反射波形可能代表中细砂沉积 ,以下的丘状或杂乱反射波形可能代表中粗砂沉积 。 | 殷勇 朱大奎 关洪军 唐文武 I Peter Martini | 2002 | 海洋地质与第四纪地质2002，22，3： | 4 |
| 6 | Bacterial presence on flexible endoscopes vs time since disinfection显示文摘AIM To correlate the length of endoscope hang time and number of bacteria cultured prior to use.METHODS Prospectively, we cultured specimens from 19 gastroscopes, 24 colonoscopes and 5 side viewing duodenoscopes during the period of 2011 to 2015. A total of 164 results had complete data denoting date of cleansing, number of days stored and culture results. All scopes underwent initial cleaning in the endoscopy suite utilizing tap water, and then manually cleaned and flushed. High level disinfection was achieved with a Medivator~? DSD(Medivator Inc., United States) automated endoscope reprocessor following manufacturer instructions, with Glutacide~?(Pharmax Limited, Canada), a 2% glutaraldehyde solution. After disinfection, all scopes were stored in dust free, unfiltered commercial cabinets for up to 7 d. Prior to use, all scopes were sampled and plated on sheep blood agar for 48 h; the colony count was obtained from each plate. The length of endoscope hang time and bacterial load was analyzed utilizing unpaired t-tests. The overall percentage of positive and negative cultures for each type of endoscope was also calculated. RESULTS All culture results were within the acceptable range(less than 200 cfu/mL). One colonoscope cultured 80 cfu/mL after hanging for 1 d, which was the highest count. ERCP scopes cultured at most 10 cfu, this occurred after 2 and 7 d, and gastroscopes cultured 50 cfu/mL at most, at 1 d. Most cultures were negative for growth, irrespective of the length of hang time. Furthermore, all scopes, with the exception of one colonoscope which had two positive cultures(each of 10 cfu/mL), had at most one positive culture. There was no significant difference in the number of bacteria cultured after 1 d compared to 7 d when all scopes were combined(day 2: P = 0.515; day 3: P = identical; day 4: P = 0.071; day 5: P = 0.470; day 6: P = 0.584; day 7: P = 0.575). There was also no significant difference in the number of bacteria cultured after 1 day compared to 7 d for gastroscopes(day 2: P = 0.895; day 3: P = identical; day 4: P = identical; day 5: P = 0.893; day 6: P = identical; day 7: P = 0.756), colonoscopes(day 2: P = 0.489; day 4: P = 0.493; day 5: P = 0.324; day 6: P = 0.526; day 7: P = identical), or ERCP scopes(day 2: P = identical; day 7: P = 0.685). CONCLUSION There is no correlation between hang time and bacterial load. Endoscopes do not need to be reprocessed if reused within a period of 7 d. | Katlin I Mallette Peter Pieroni Sonny S Dhalla | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 3 |
| 7 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 8 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 9 | 人体-座椅接触面温湿度采集系统设计与实现显示文摘介绍了一种人体-座椅接触面温湿度采集系统,该系统采用AM2301温湿度传感器,经单片机处理后,由液晶屏实时显示温度和相对湿度数据,并将数据储存到SD卡中,供离线分析使用.在进行测量实验前,对系统所使用的3个温湿度传感器的输出一致性进行了测试,测试结果显示:AM2301传感器温度标准方差为±0.3℃,相对湿度标准方差为±0.5%,满足系统设计要求.利用该系统对5名志愿者进行了人体-座椅接触面温湿度采集实验,每次采集时间为1 h.测量结果分析表明:实验中三个温湿度传感器所在位置温度差别很小,而相对湿度却差别很大,反映了人体-座椅接触面相对湿度受传感器布放位置的影响很大. | 刘卓夫 罗中明 姜伟 CASCIOLI Vincenzo HEUSCH I Andrew MCCARTHY W Peter | 2013 | 哈尔滨理工大学学报2013，18，6： | 2 |
| 10 | Primary graft dysfunction after liver transplantation: From pathogenesis to prevention显示文摘 | Khalid I Bzeizi Rajiv Jalan John N Plevris Peter C Hayes | 2003 | Liver Transpl2003，，2： | 2 |
| 11 | Malignant schwannoma of the breast显示文摘 | Bsznyak I Dubecz S Peter I | 1998 | Orv Hetil1998，139，3： | 1 |
| 12 | Pentacyclic taiterpenes from the Fruits of Rosa Sterilis 显示文摘 | Guangyi L Alexander I Peter G 1989 | 1989 | Journal of Natural Products1989，52，1： | 1 |
| 13 | Simplified method for reoperation on the mitral valve显示文摘 | Peter I Richard W Richard A | 1989 | Ann Thorac Surg1989，48，： | 1 |
| 14 | From SHIQ and RDF to OWl:The Making of a Web Ontology Language显示文摘 | Horocks I Peter F | 2003 | J of Web Semantics2003，1，1： | 1 |
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| 16 | The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia显示文摘 | Hubeek I Litvinova E Peters GJ | 2004 | Int J Oncol2004，25，6： | 1 |
| 17 | A Tutorial on Visual Servo Control显示文摘 | Seth H Gregory D H Peter I C | 1996 | IEEE Trans on Robotics and Automation1996，12，65： | 1 |
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| 19 | Inhaled nanoparticles: a current review显示文摘 | YANG Wei PETERS J I WILLIAMS R O | 2008 | International Journal of pharmaceutics2008，356，2： | 1 |
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