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| 1 | Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma显示文摘AIM: To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients. METHODS: A prospective cohort study, from 2001 to 2010, compared clinical outcomes following TACE between patients ≥ 75 years old and younger patients (aged between 65 and 75 years and younger than 65 years) with hepatocellular carcinoma (HCC), diagnosed according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases criteria. The decision that patients were not candidates for curative therapy was made by a multidisciplinary HCC team. Data collected included demographics, co-morbidities, liver disease etiology, liver disease severity and the number of procedures. The primary outcome was mortality; secondary outcomes included post-embolization syndrome (nausea, fever, abdominal right upper quadrant pain, increase in liver enzymes with no evidence of sepsis and with a clinical course limited to 3-4 d post procedure) and 30-d complications. Additionally, changes in liver enzyme measurements were assessed [alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transpeptidase and alkaline phosphatase] in the week following TACE. Analysis employed both univariate and multivariate methods (Cox regression models). RESULTS: Of 102 patients who underwent TACE as sole treatment, 10 patients (9.8%) were > 80 years old at diagnosis; 13 (12.7%) were between 75 and 80 years, 45 (44.1%) were between 65 and 75 years and 34 (33.3%) were younger than 65 years. Survival analysis demonstrated similar survival patterns between the elderly patients and younger patients. Age was also not associated with the adverse event rate. Survival rates at 1, 2 and 3 years from diagnosis were 74%, 37% and 31% among patients < 65 years; 83%, 66% and 48% among patients aged 65 to 75 years; and 86%, 41% and 23% among patients ≥ 75 years. There were no differences between the age groups in the pre-procedural care, including preventive treatment for contrast nephropathy and prophylactic antibiotics. Multivariate survival analysis, controlling for disease stage at diagnosis with the Barcelona Clinic Liver Cancer score, number of TACE procedures, sex and alphafetoprotein level at the time of diagnosis, found no significant difference in the mortality hazard for elderly vs younger patients, and there were no differences in post-procedural complications. Serum creatinine levels did not change after 55% of the procedures, in all age groups. In 42% of all procedures, serum creatinine levels increased by no more than 25% above the baseline levels prior to TACE. Overall, there were 69 post-embolization events (23%). Hepatocellular enzymes often increased following TACE, with no association with prognosis. In 40% of the procedures, ALT and AST levels rose by at least 100%. The increases in hepatocellular enzymes occurred similarly in all age groups. CONCLUSION: TACE is safe and effective in very elderly patients with HCC, and is not associated with decreased survival or increased complication rates. | Matan J Cohen Allan I Bloom Orly Barak Alexander Klimov Tova Nesher Daniel Shouval Izhar Levi Oren Shibolet | 2013 | World Journal of Gastroenterology2013，19，16： | 13 |
| 2 | 基于改进PNCC特征和两步区分性训练的录音设备识别方法显示文摘录音设备来源识别是通过分析已获取的数字语音信号从而确定其录制设备的一种技术,属于数字音频盲取证.本文提出了一种基于改进PNCC特征和两步区分性训练的录音设备识别方法,由于音频中的静音包含了完整的设备信息,且不受说话人和文本等因素的影响,因此从静音段提取改进的PNCC特征,利用了PNCC的长时帧分析去除背景噪声对设备信息的影响.在模型方面,以GMM-UBM为基准模型,并通过两步区分性训练调整集内设备模型和通用背景模型,提升模型区分能力.该方法对于30种设备闭集识别的平均正确识别率为90.23%;对于15个集内和15个集外设备的测试,等错误率为15.17%,集内平均正确识别率为96.65%,验证了本文算法的有效性. | 贺前华 王志锋 Alexander I Rudnicky 朱铮宇 李新超 | 2014 | 电子学报2014，42，1： | 9 |
| 3 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 4 | 分娩所致Valsalva视网膜病变治疗方法的探讨(英文)显示文摘目的:讨论孕妇Valsalva视网膜病变保守或手术治疗方法的选择。方法:一健康孕妇在自然阴道分娩时,右眼底发生黄斑前玻璃体后界膜下出血,本文报道其保守治疗的效果。结果:右眼发病3wk时积血收缩,视力为眼前手动,但病程6mo时,积血溶解,视力恢复至6/5。结论:大多数Valsalva视网膜病变能够自愈。对一些难治性病例,采用Nd:YAG激光行内界膜切开具有一定的效果。而早期玻璃体切除术的增殖膜切除,对预防眼底新生血管膜的发生也具有一定的效果。 | Konstantinos I Papageorgiou Rashmi G Mathew AlexanderS Ioannidis Ajay Sinha Petros S Andreou | 2007 | 国际眼科杂志2007，7，3： | 3 |
| 5 | Unique Marine Olenekian-Anisian Boundary Section from South Primorye, Russian Far East显示文摘To show paleontological characteristics of the Olenekian-Anisian boundary beds in the Russian Far East, a review of new data on the Upper Olenekian and Lower Anisian biostratigraphy of South Primorye is given on the basis of five sections: Golyi Cape, Petrovka River, Zhitkov Peninsula, Tchernyschew Bay and Atlasov Cape, using new ammonoid, brachiopod and conodont findings. The most representative ammonoid assemblage at the base of the Anisian was discovered in the Ussuriphyllites amurensis Zone (10.6 m thick) of the Atlasov Cape Section: Parasageceras sp. nov., Prionitidae gen. et sp. nov., Ussuriphyllites amurensis (Kiparisova) (dominant), Megaphyllites atlasoviensis Zakharov, Leiophyllites praematurus Kiparisova, Leiophyllites sp., Ussurites sp., Paradanubites sp. indet., Paracrochordiceras sp. nov., Prohungarites popowi Kiparisova, Arctohungarites primoriensis Zakharov, A. solimani (Toula), Salterites sp. indet. (gigantic shell), and Tropigastrites sublachontanus Zakharov. Conodonts Neospathodus cf. homeri (Bender) were found in the lower part of the Ussuriphyllites amurensis Zone of the Atlasov Cape. The Atlasov Cape seems to be one of the very promising sections of the Russian Far East for detailed investigation of the Olenekian-Anisian boundary. | Yuri D Zakharov Alexander M Popov Galina I Buryi | 2005 | Journal of China University of Geosciences2005，16，3： | 3 |
| 6 | Delayed assessment and eager adoption of laparoscopic cholecystectomy:Implications for developing surgical technologies显示文摘Despite the prevailing emphasis in the medical literature on establishing evidence,many changes in the practice of surgery have not been achieved using proper evidence-based assessment.This paper examines the adoption of laparoscopic cholecystectomy(LC)into regular use for the treatment of cholecystitis and the process of its acceptance,focusing on the limited role of technology assessment in its appraisal.A review of the published medical literature concerning LC was performed.Approximately 3000 studies of LC have been conducted since 1985,and there have been nearly 8500 publications to date.As LC was adopted enthusiastically into practice,the results of outcome studies generally showed that it compared favorably with the traditional,open cholecystectomy with regard to mortality,complications,and length of hospital stay.However,despite the rapid general agreement on surgical technique,efficacy,and appropriateness,there remained lingering doubts about safety,outcomes,and cost of the procedure that suggested that essential research questions were ignored even as the procedure became standard.Using LC as a case study,there are important lessons to be learned about the need for important guidelines for surgical innovation and the adoption of minimally invasive surgical techniques into current clinical and surgical practice.We highlight one recent example,natural orifice transluminal endoscopic surgery and how necessary it is to properly evaluate this new technology before it is accepted as a safe and effective surgical option. | Alexander C Allori I Michael Leitman Elizabeth Heitman | 2010 | World Journal of Gastroenterology2010，16，33： | 3 |
| 7 | An infertile male with dilated seminal vesicles due to functional obstruction显示文摘 | Michael D Font Alexander W Pastuszak John R Case Larry I Lipshult | 2017 | Asian Journal of Andrology2017，19，2： | 2 |
| 8 | Synthesis of Gold Nanoparticles by Some Strains of Arthrobacter Genera显示文摘 | Tamaz Levan Kalabegishvi|i Elena Ivan Kirkesalt Alexander Nikoloz Rcheulishvili Etery Nikoloz Ginturi Ivane Giorgi Murusidze Dodo Trofim Pataraya Manana Amiran Gurielidze Giorgi Ilia Tsertsvadze Vakhtang Nikoloz Gabunia Levan Giorgi Lomidze David Nugzar Gvarialadze Marina VladimirovnaFrontasyeva Sergey Sergeevich Pavlov Inga Ivanovna Zinicovscaia Marianne Janette Raven Ntsoaki Maditselana Francinah Seaga Arnaud Faanhof | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 2 |
| 9 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 10 | The expanded supraclavicular flap, prefabricated with thoracoacromial vessels, for reconstruction of postburn anterior cervical eontractures 显示文摘 | Alexander M Keren A Michael I | 2007 | Hast Reconstr Surg2007，119，7： | 1 |
| 11 | Configurational isomerization in sedimentary bicyclic alkanes 显示文摘 | Noble R A Alexander R Kagi R I | 1987 | Org Geochem1987，11，3： | 1 |
| 12 | Pentacyclic taiterpenes from the Fruits of Rosa Sterilis 显示文摘 | Guangyi L Alexander I Peter G 1989 | 1989 | Journal of Natural Products1989，52，1： | 1 |
| 13 | Identification of some diterpenoid hydrocarbons in petroleum显示文摘 | Noble R A Alexander R Kagi R I | 1986 | Organic Geochemistry1986，10，： | 1 |
| 14 | 显示文摘 | Peter I Ravikoviteh Gary L Haller Alexander V Neimark | 1998 | Advances in Colloid and Interface Science1998，7677，： | 1 |
| 15 | Continuous-wave Singly Resonant Optical Parametric Oscillator Based on Periodically Poled LiNbO3 显示文摘 | BOSENBERG W R DROBSHOFF A ALEXANDER J I | 1996 | Opt Lett1996，21，10： | 1 |
| 16 | Biodegradation of aromatic hydrocarbons in crudes oils from the Barrow Sub-basin of Western Australia显示文摘 | Volkman J K Alexander R Kagi R I Rowland S J Sheppard P N | 1984 | Org Geochem1984，6，62： | 1 |
| 17 | Avian influenza: recent developments 显示文摘 | Capua I Alexander DJ | 2004 | Avian Pathol2004，33，： | 1 |
| 18 | Isolation of an influenza A virus of unusual subtype(H1N7) from pigs in England,and the subsequent experimental transmission from pig to pig显示文摘 | BROWN I H ALEXANDER D J CHAKRAVERTY P | 1994 | Vet Microbiol1994，39，12： | 1 |
| 19 | History of highly pathogenic avian influenza显示文摘 | Alexander D J Brown I H | 2009 | Rev Sci Tech2009，8，1： | 1 |
| 20 | The Riemann-Hilbert problem and integrable systems显示文摘 | Alexander R I | 2003 | Notices of the AMS2003，50，1： | 1 |
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