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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Stroke rehabilitation:analysis of repeated Barthel index measures显示文摘 | Granger CV Dewis LS Peters NC | 1979 | Arch Phys Med Rehabil1979，60，： | 1 |
| 3 | Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder:3-year results of the STEP study显示文摘 | PETERS KM CARRICO DJ WOOLDRIDGE LS | 2013 | J Urol2013，189，6： | 1 |
| 4 | Creatine feeding increase Glut - 4 expression in rat skeletal musele显示文摘 | Jeong- Sun J Jill LS Peter JO | 2005 | Amphysiol Endocri nol2005，，288： | 1 |
| 5 | Stroke rehabilitation:analysis of repeated Barthel index measures显示文摘 | Granger CV Dewis LS Peters NC | 1979 | Arch Phys Med Rehabil1979，60，： | 1 |
| 6 | Managing discontinuous innovation显示文摘 | RICE MP COLARELLI O'CONNOR G PETERS LS MORONE JG | 1998 | Research Technology Management1998，41，3： | 1 |
| 7 | Percutaneous tibial nerve stimulation for the longterm treatment of overac- tive bladder: 3-year results of the STEP study 显示文摘 | Peters KM Carrico D J Wooldridge LS | 2013 | J Urology2013，189，6： | 1 |
| 8 | Stroke rehabilitation: analysis of repeated Barthel index measures显示文摘 | Granger CV Dewis LS Peters NC | 1979 | Arch Phys Med Rehabil1979，60，1： | 1 |
| 9 | Randomized trial of- percutaneous tibial nerve stimulation versus extended-release toherodine: results from the overactive bladder innovative therapy trial 显示文摘 | Peters KM Macdiarmid SA Wool- dridge LS | 2009 | J Urol2009，182，3： | 1 |
| 10 | Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis显示文摘 | Ludger Sch?ls Peter Bauer Thorsten Schmidt Thorsten Schulte Olaf Riess | 2004 | Lancet Neurology2004，，5： | 1 |
| 11 | The children's eating behavior inventory:reliability and validity results显示文摘 | Lynda AA Peter LR David LS | 1991 | Journal of Pediatric Psychology1991，16，5： | 1 |
| 12 | Stroke rehabi-litation:analysis of repeated Barthel index measures显示文摘 | Granger CV Dewis LS Peters NC | 1979 | Arch Phys Med Rehabil1979，60，1： | 1 |
| 13 | Ran- stimulation versus extended-release toherodine:results from the Over- active Bladder Innovative Therapy(OrBIT) Trial显示文摘 | Peters KM MacDiarmid SA Wooldridge LS domized trial of percutaneous tibial nerve | 2009 | J Urol2009，，182： | 1 |
| 14 | Innate Immune Respon- ses Are Increased in Chronic Obstructive Pulmonary Disease 显示文摘 | Katherine JB Jodie LS Peter GG | 2011 | Incrs Inn Inmn Resps in COPD2011，6，3： | 1 |
| 15 | SCA3: Neurological features, pathogenesis and animal models显示文摘 | Olaf Riess Udo Rüb Annalisa Pastore Peter Bauer Ludger Sch?ls | 2008 | The Cerebellum2008，，2： | 1 |
| 16 | Karyotypic analysis predicts outcome of preremission: a Southwest Oncology Group/Eastern Cooperative Oncology Group study 显示文摘 | F Manilyn LS Kenneth JK Peter AC | 2000 | Blood2000，96，： | 1 |
| 17 | Randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine:results From the overactive bladder innovative therapy trial显示文摘 | Peters KM Macdiarmid SA Wooldridge LS | 2009 | Journal of Urology2009，182，3： | 1 |
| 18 | High spontaneous IL-18 production in unrelated marrow transplant recipients is associated with fe- wer transplant-related complications and early deaths 显示文摘 | Baker ]LS Ronearolo KG Peters C | 1999 | J Bone Marrow Transplant1999，23，3： | 1 |
| 19 | Determinants of outcomes of sinus surgery : a multi-institutional prospective co- hort study 显示文摘 | Timolthy LS Jaminie RL Peter HH | 2010 | Otolaryngol Head Neck Surg2010，142，1： | 1 |
| 20 | Randomized trial of pereutaneous tlbial nerve stimulation versus extended-re- lease tolterodine: resuhs from the overactive bladder innovative therapy trial 显示文摘 | Peters KM MacDiarmid SA Wooldridge LS | 2009 | J Urol2009，182，： | 1 |
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