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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 3 | Racial differences in effectiveness of α-fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis显示文摘 | Mindie H Nguyen Ruel T Garcia Peter W Simpson Teresa L Wright Emmet B Keeffe | 2002 | Hepatology2002，，2： | 2 |
| 4 | A comparison study of improved Hilbert-Huang transform and wavelet transform:Application to fault diagnosis for rolling bearing显示文摘 | Peng Z K Peter W T Chu F L | | 0，，5： | 1 |
| 5 | A comparison study of improved Hilbert-Huang transform and wavelet transform:Application to fault diagnosis for rolling bearing显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Mechanical Systems and Signal Processing2005，19，： | 1 |
| 6 | Osteopontin reduces biofilm formation in a multispecies model of dental biofilm显示文摘 | Sebastian S Merete K R Peter L W | 2012 | PloS One2012，7，41： | 1 |
| 7 | The changing automotive environment: high-temperature electronics 显示文摘 | Johnson R W Evans J L Jacobsen Peter | 2004 | IEEE transactions on electronics packaging manufacturing2004，27，3： | 1 |
| 8 | Remote sensing, diagnosis and collaborative maintenance with web-enabled virtual instruments and mini-servers 显示文摘 | Wang J F Peter W T He L S | 2004 | The International Journal of Advanced Manufacturing Technology2004，24，6： | 1 |
| 9 | Performance evaluation of efficient and reliable routing protocols for fixed-power sensor networks显示文摘 | PETER K K L HSU W J YI P | | 0，，05： | 1 |
| 10 | Von Hippel-Lindau disease:genetic,clinical,and imaging feature显示文摘 | Peter L C Gladys M G Meclellan M W | 1995 | Radiology1995，194，： | 1 |
| 11 | An improved Hilbert-Huang transform and its application in vibration signal analysis显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Journal of Sound and Vibration2005，286，： | 1 |
| 12 | Ethanol-diesel fuel blends--A Review 显示文摘 | HANSEN Alan C ZHANG Qin LYNE Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 13 | Accuracy of the Lattice Boltzmann Method for Low-Speed Noncontinuum Flows 显示文摘 | SHI Yong Peter L B Ying W Y | 2011 | Physical Review E2011，83，04： | 1 |
| 14 | A comparison study of improved Hilbert-Huang transform and wavelet trans- form: application to fault diagnosis for rolling bearing 显示文摘 | Peng Z K Peter W Chu F L | 2005 | Mechanical Systems and Signal Processing2005，19，1： | 1 |
| 15 | Gene silencing as an adaptive defence against viruses显示文摘 | Peter M W Ming-Bo W Tony L | 2001 | Nature2001，411，14： | 1 |
| 16 | An Improved Hilbert-Huang Transform and Its Application in Vibration Analysis显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Journal of Sound and Vibration2005，286，12： | 1 |
| 17 | Digital current control of a voltage source converter with active damping of LCL resonance显示文摘 | WU E L PETER W | 2006 | IEEE Transactions on Power Electronies2006，21，5： | 1 |
| 18 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 19 | Gene silenceing as an adaptive defence against viruses显示文摘 | Peter MW Ming Bo W Tony L | 2001 | Nature2001，4，11914： | 1 |
| 20 | Ethanol-diesel fuel blends:A review显示文摘 | Hansen Alan C Zhang Qing Lyne Peter W L | 2005 | Bioresource Technology2005，96，： | 1 |
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