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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 3 | Intracpidermal cells of Paget's carcinoma of the breast can be genetically different from those of the underlying carcinoma显示文摘 | Morandi L Pession A Marucci GL | 2003 | Hum Pathol2003，34，12： | 1 |
| 4 | Use of recombinanthuman granuloeyte colony-stimulating factor in children given allogeneic born marrow transplantation for acute or chronic leukemia显示文摘 | Locatelli F Pession A Zecca M | 1996 | Bone Marrow Transplant1996，17，1： | 1 |
| 5 | Current outcome of portal vein thrombosis in adults: Risk and benefit of anticoagulant therapy显示文摘 | Bertrand Condat Fabienne Pessione Sophie Hillaire Marie-Helene Denninger Marie-Claude Guillin Marc Poliquin Antoine Hadengue Serge Erlinger Dominique Valla | 2001 | Gastroenterology2001，，2： | 1 |
| 6 | Recent Portal or Mesenteric Venous Thrombosis: Increased Recognition and Frequent Recanalization on Anticoagulant Therapy显示文摘 | Bertrand Condat Fabienne Pessione Marie Helene Denninger Sophie Hillaire Dominique Valla | 2000 | Hepatology2000，，3： | 1 |
| 7 | Clinical characteristics and out- come of patients with cirrhosis and refractory ascites 显示文摘 | Moreau R Delegue P Pessione F | 2004 | Liver Int2004，24，4： | 1 |
| 8 | Phenol hydrox- ylase from Acinetobacter radioresistens is a multicom- ponent enzyme 显示文摘 | Pessione E Divari S Griva E | 1999 | European J Biochem1999，265，2： | 1 |
| 9 | Prental historyofalcoholism:arisk factor for alcohol-related peripheral neuropathies显示文摘 | Gerchstein JL RueffB | 1995 | Alcohol and Alcoholism1995，30，6： | 1 |
| 10 | Lactic acid bacteria contribution to gut microbiota complexity:lights and shadows显示文摘 | Pessione E | 2012 | Frontiers in Cellular&Infection Microbiology2012，2，6： | 1 |
| 11 | A proteomic approach to studying biogenic amine producing lactic acid bacteria 显示文摘 | Pessione E Mazzoli R Giuffrida MG | 2005 | Proteomics2005，5，3： | 1 |
| 12 | Hematopoietic stem cell transplantation in childhood: report from the bone marrow transplantation group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) 显示文摘 | PESSION A RONDELLI R PAOLUCCI P | 2000 | Haematologica2000，85，6： | 1 |
| 13 | Recent portal or ruesenteric venous thrombosis:increased recognition and frequent recanalization on anticoagulant therapy 显示文摘 | Condat B Pessione F Helene Denninger M | 2000 | Hepatology2000，32，： | 1 |
| 14 | Nucleolar size indicates the rapidity of cell proliferation in cancer tissues 显示文摘 | Derenzini M Trere D Pession A | 2000 | J Pathol2000，191，： | 1 |
| 15 | The Ag-NOR proteins and transcription and duplication of ribosomal genes in mammalian cell nucleoli显示文摘 | A. Pession F. Farabegoli D. Treré F. Novello L. Montanaro S. Sperti F. Rambelli M. Derenzini | 1991 | Chromosoma1991，，4： | 1 |
| 16 | Prognostic significance of ventricular blood in supratentorial hemorrhage:a ventricular study显示文摘 | Young WB Lee KP Pession MS | 1999 | Neurology1999，40，6： | 1 |
| 17 | Clinical cirrhosis and type hepatorenal syndrome treated with terlipressin: a retrospective ananlysis显示文摘 | Colle I Durand F Pessione F | 2002 | J Gastroenteml Hepatol2002，17，： | 1 |
| 18 | Aquaretic effects of niravoline,a kappa opioid agonist,in patients with cirrhosis显示文摘 | Gadano A Moreau R Pessione F | 2000 | J Hepatol2000，32，： | 1 |
| 19 | Institutional variability in transfusion practice for liver transplantation显示文摘 | Ozier Y Pessione F Samain Emmanuel | 2003 | Anesth Analg2003，97，3： | 1 |
| 20 | Recent portal or mesenteric venous thrombosis increased recognition and fre- quent recanalization on anticoagulant therapy 显示文摘 | Condat B Pessione F Helene Denninger M | 2000 | Hepatolgy2000，32，： | 1 |
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