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| 1 | Percutaneous coronary intervention in nonagenarians: pros and cons显示文摘Percutaneous coronary intervention is a mainstay in the management of symptomatic or high-risk coronary artery disease. The bulk of clinical evidence and experience underlying this fact relies, however, on relatively young patients. Indeed, few data of very limited quality are available which adequately define the risk-benefit and cost-benefit profile of coronary angioplasty and stenting in very old subjects, such as those of 90 years of age or older (i.e., nonagenarians). The aim of this review is to provide a concise, yet practical, synthesis of the available evidence on percutaneous coronary revascularization in the very elderly. The main arguments elaborated upon are to what extent we can extrapolate findings from studies including younger patients to nonagenarians, whether we should provide higher priority to prognosis or quality of life in such patients, and whether we can afford to allocate vast resources to care for such subjects in an era of financial constraints. Our review of 18 studies and 1082 patients suggest that percutaneous coronary intervention is feasible and associated with acceptable short- and long-term results in this population, which is nonetheless fraught with a high mortality risk irrespective of the revascularization procedure. Accordingly, the pros and cons of percutaneous coronary intervention should be carefully weighed when considering this treatment in nonagenarians. | Giuseppe Biondi Zoccai Antonio Abbate Fabrizio D'Ascenzo Davide Presutti Mariangela Peruzzi Elena Cavarretta Antonino G.M. Marullo Marzia Lotrionte Giacomo Frati | 2013 | Journal of Geriatric Cardiology2013，10，1： | 6 |
| 2 | MMPll: a novel target antigen for cancer immunotherapy显示文摘 | Peruzzi D Moil F Conforti A | 2009 | Clin Can- cer Res2009，15，12： | 1 |
| 3 | Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy显示文摘 | Dharmawardana P G Peruzzi B Giubellino A Burke T R Jr Bottaro D P | 2006 | Anticancer Drugs2006，17，： | 1 |
| 4 | Lhermitte-Duclos disease associated with syringomyelia 显示文摘 | Marcus C D Galeon M Peruzzi P | 1996 | Neuroradiology1996，38，6： | 1 |
| 5 | Male are cheaper,or the extreme consequence of size/agedependent sex allocation:sexist gender diphasy in Fritillaria montana (Liliaceae)显示文摘 | Peruzzi L Manciso E Gargano D 2012 | 2012 | Botanical Journal of the Linnean Society2012，168，： | 1 |
| 6 | The use of Pig-a as a sentinel gene for the study of the somatic mutation rate and of mutagenie agents in vivo显示文摘 | Peruzzi B Araten D J Notaro R | 2010 | Mutat Res2010，705，1： | 1 |
| 7 | Role of promyelocytic leukemia (PML) protein in tumor suppression 显示文摘 | Ego EM Wang ZG Peruzzi D | 2001 | J Exp Med2001，193，4： | 1 |
| 8 | Hydraulic and biochemical analyses on full scale sludge stabilization reed beds in Tuscany(Italy)显示文摘 | Giraldi D Masciandaro G Peruzzi E | 2009 | Water Sci Technol2009，60，： | 1 |
| 9 | Postoperative spinal extradural hematomas 14 causes显示文摘 | Scavarda D Peruzzi P Bazin A | | 0，，04： | 1 |
| 10 | Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through coopera:tive mechanisms involving the αvβ3 integrin, osteopontin, and thrombin 显示文摘 | Senger D R Ledbetter S R Claffey K P Papadopoulos Sergiou A Peruzzi C A Detmar M | 1996 | Am J Pathol1996，149，： | 1 |
| 11 | Role of promyelocytic leukemia(PML) protein in tumor suppression显示文摘 | Rego EM Wang ZG Peruzzi D | 2001 | J Exp Med2001，193，4： | 1 |
| 12 | Targeting the c-Met signa- ling pathway in cancer 显示文摘 | Peruzzi B Bottaro D P | 2006 | Clinical Cancer Re- search2006，12，12： | 1 |
| 13 | The combined effect of roughness and heterogeneity on contact angles: The case of polymer coating for stone protection显示文摘 | Volpe C D Penati A Peruzzi R | 2000 | Journal of Adhesion Science and Technology2000，14，2： | 1 |
| 14 | Males are cheaper,or the extreme consequence of size/age-dependent sex allocation:sexist gender diphasy in Fritillaria montana(Liliaceae)显示文摘 | Peruzzi L Mancuso E Gargano D | 2012 | Botanical Journal of the Linnean Society2012，168，3： | 1 |
| 15 | GABA,serotonin and serotonin receptors in the rat inferior colliculus显示文摘 | Peruzzi D Dut A | 2004 | Brain Res2004，998，2： | 1 |
| 16 | Hydraulic and biochemical analyses on full-scale sludge consolidation reed beds in Tuscany ( Italy ) 显示文摘 | Giraldi D Masciandaro G Peruzzi E | 2011 | Water Science & Technology2011，60，5： | 1 |
| 17 | Efficacy and tolerabilityof valsartan compared with lisinopril in patients with hypertension and renal insufficiency显示文摘 | Spormann D Peruzzi E | 1997 | Clin Drug Invest1997，14，： | 1 |
| 18 | Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of miR-128a显示文摘 | Eletto D Russo G Passiatore G Valle LD Giordano A Khalili K Gualco E Peruzzi F | 2008 | J Cell Physiol2008，216，3： | 1 |
| 19 | A novel mouse model for evaluation and prediction of HLA-A2-restricted CEA cancer vaccine responses显示文摘 | Conforti A Peruzzi D Giannetti P | | 0，，07： | 1 |
| 20 | MMP11: a novel target antigen for cancer immunotherapy 显示文摘 | Peruzzi D Mori F Conforti A | 2009 | Clin Cancer Res2009，15，12： | 1 |
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